National Repository of Grey Literature 3 records found  Search took 0.00 seconds. 
Mosquito flaviviruses in the Czech Republic
Majerová, Karolina ; Votýpka, Jan (advisor) ; Kopecký, Jan (referee)
Flaviviruses (genus Flavivirus, family Flaviviridae) includes a number of medically and veterinary important arboviruses. Most of them are transmitted by mosquitoes, such as West Nile virus, yellow fever virus, dengue virus or Zika virus. In the last decade, there has been discovered number of flaviviruses which have not known vertebrate host. They are called insect-specific flaviviruses (ISFs). These viruses have been detected in dipteran insects (mostly in mosquitoes) from all over the world. It seems they induce no pathogenic changes even in insect and they are not able to infect any vertebrate cells. However in some recent studies has been shown that some ISFs could influence the replication of other medically important flaviviruses in mosquito cells. In addition, they probably represent an ancestrial lineage of the family Flaviviridae and further studies focused on them could help to clarify which characteristics of flaviviruses enable them to infect vertebrates. There is not a lot of information about the ecology of ISFs and it is suggested that most ISFs have not been discovered yet. Main goal of this thesis was to detect ISFs in mosquitoes in the Czech Republic, where have not been made any exstensive research of these viruses yet. In case of discover some undiscribed ISFs we wanted to characterize...
Sand flies as hosts of monoxenous and dixenous trypanosomatids
Vondráček, Oldřich ; Votýpka, Jan (advisor) ; Jirků, Kateřina (referee)
Phlebotomine sandflies are blood sucking Dipteran and important vectors of various patogens, especially leishmania parasites (Trypanosomatida, Leishmaniinae). Apart from the genus Leishmania they also transmit variety of other parasites and they are considered to be vectors of trypanosomes (genus Trypanosoma) and hosts of some monoxenous trypanosomatids. This Master thesis is focused on the occurrence and development of mono- and dixenous trypanosomatids (other than the genus Leishmania) in sandflies. We studied experimental infections of various species of sandflies and mosquitoes by two species of trypanosomes and one species of monoxenous parasite (Strigomonas galati). All three studied trypanosomatid species were isolated from sandflies. Further concern of the thesis is the transmission of both species of trypanosomes from sandflies to vertebrate hosts and the transmission of monoxenous parasite between insect hosts and also morphological changes of parasite cells during the development in a culture and in the insect and vertebrate hosts.

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