National Repository of Grey Literature 46 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Genetics and molecular basis of spina bifida
Kim, Alice ; Krylov, Vladimír (advisor) ; Hovořáková, Mária (referee)
Spina bifida is a neural tube defect that evolves during neurulation when the neural folds fail to fuse and result in an open neural tube. New studies have shown that our understanding of neural tube closure might be wrong and suggested a single site neural tube closure in humans. Various factors like nutrition, genetics, and environment lead to the formation of a neural tube defect. Folic acid and Vitamin B12 have been shown as effective supplements when it comes to lowering the risk of developing NTD and. Genetic mutations of MTHFR, CUBN, CHKA, SARDH, MTRR, Grhl-3, which are all involved in methylations are considered important risk factors for NTD's. Wrong methylation or hypomethylation of Hox and Vangl genes have shown to be also playing a role in NTD's. Par1/Par2 mutations in mice have shown to cause Spina Bifida. Keywords: Spina Bifida, NTD, Neural tube defects, Myelomeningocele, Neurulation
Ecology of yeasts in forest soils
Mašínová, Tereza ; Baldrian, Petr (advisor) ; Marečková, Markéta (referee) ; Kolařík, Miroslav (referee)
Microbial communities inhabiting upper soil horizons represent an important component of forest ecosystems. However, despite the evidence that yeasts represent an integral part of topsoil fungal communities, their role in forest ecosystems received so far little attention. The aims of my PhD thesis were to describe yeast communities in soil and litter of a temperate forest using high- throughput sequencing of environmental DNA, identify dominant yeast species and to explore how the composition of yeast communities reflects the biotic and abiotic factors of the environment. I also aimed to isolate yeasts from forest topsoil, describe novel yeast taxa abundant according to the environmental DNA survey and screen representative isolates for the traits relevant to their involvement in organic matter transformation. I have demonstrated that in forest topsoil, yeasts represent a substantial proportion of fungal communities with higher relative abundance in soil than in litter. In litter, yeast communities differ significantly among beech, oak and spruce-dominated stands. Drivers of community assembly are probably more complex in soils and comprise the effects of soil chemistry and vegetation. Even though there are similarities in the response of the communities of yeasts and filamentous fungi to...

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