National Repository of Grey Literature 81 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Advanced lipidomics in selected clinical conditions
Staňková, Barbora ; Tvrzická, Eva (advisor) ; Hyánek, Josef (referee) ; Kazdová, Ludmila (referee)
Abnormalities of lipid metabolism are considered risk factors for cardiovascular, metabolic, nephrologic diseases amd some malignancies, as well. Nowadays, a lot of effort is devoted to study new risk factors and surrogate markers of conditions mentioned above to improve their prognosis and decrease mortality. The aim of this thesis was to provide a comprehensive survey of lipid metabolism, characteristics of different lipid compounds in health and diseases and of possibilities of utilization of selected lipid parameters in the diagnostics of pathological conditions listed above. Selected lioid parameters were observed in several studies, focused on specific pathological conditions. Besides conventional lipid analytes, the composition of fatty acids in plasma lipid pools was studied in healthy controls, and in the patients suffering from metabolic syndrome, chronic pancreatitis, and pancreatic cancer, as well. Markers of an oxidative stress (oxidatively modified LDL particles and conjugated dienes in precipitated LDL) were assessed in healthy controls, patients with metabolic syndrome, chronic pancreatitis, pancreatic cancer, and in the patients with different concentrations of plasma apoB-48, too. LDL particles subfraction were investigated in healthy controls, in the patients with different...
Natural compounds applicable for the treatment of metabolic syndrome
Hradecká, Michaela ; Karlíčková, Jana (advisor) ; Kašparová, Marie (referee)
Hradecká M.: Natural compounds applicable for the treatment of metabolic syndrome, Diploma thesis 2018/2019, Charles University, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Botany, pp. 60. Occurence of metabolic syndrome is increasing worldwide in children and adults. The use of natural compounds is one of possibilities in the prevention and treatment of metabolic syndrome. These compounds may act complexly or affect individual risk factors associated with metabolic syndrome. Selected plants with these effects are incorporated into my diploma thesis (for example Allium sativum, Crataegus laevigata, Hibiscus sabdariffa, Persea americana, Rosmarinus officinalis, Silybum marianum and Vaccinium myrtillus). The alga Undaria pinnatifida and fungus Pleurotus sajor-caju are also mentioned. It is necessary to carry out other clinical studies, where the positive effect of mentioned constituents will be confirmed, which could be added to the list of phytopharmaceuticals used to prevent, slow down or treat the metabolic syndrome in the future. Keywords: natural compounds, metabolic syndrome
Dietary prevention of type 2 diabetes mellitus
Nováková, Veronika ; Flekač, Milan (advisor) ; Mikeš, Ondřej (referee)
This thesis deals with dietary prevention of type 2 diabetes mellitus. The first chapters of the thesis deal with general information about diabetes mellitus. The chapters focus on the classification, epidemiology, clinical manifestation, complications, diagnostics of diabetes mellitus and pathogenesis of type 2 diabetes mellitus. The subsequent chapters describe prediabetes, obesity and metabolic syndrome. The conclusion of the theoretical section is devoted to the prevention of type 2 diabetes mellitus. The prevention is focused on non-pharmacological measures with an emphasis on dietary influences. The practical part is based on anonymous quantitative research in the form of an Internet quastionaire survey, which focuses on the prevention of type 2 diabetes mellitus. The main goal was to find out about the public's awareness of dietary effects on type 2 diabetes mellitus. The secondary objectives examine the awareness of the worlwide increase of diabetics and whether the respondents consider sugar to be the cause of type 2 diabetes mellitus and attach greater importance to healthy lifestyle or pharmacological measures in prevention. The survey results relating to dietary influences were not very satisfactory and respondents' poor awareness regarding prevention was reflected, for example in...
Pharmacotherapy of metabolic syndrome and nutrition
Nesvadbová, Eliška ; Matoulek, Martin (advisor) ; Bartošová, Olga (referee)
Introduction: Metabolic syndrome is considered a proatherogenic, proinflammatory and prothrombogenic condition, high-risk especially in terms of atherosclerotic cardiovascular diseases. Presence of metabolic syndrome is connected with plenty of other disorders. The prevalence in adult European population is 20-30 % and it's expected to rise in the future. In metabolic syndrome treatment and prevention non-pharmacological therapy including regular physical activity, keeping of optimal weight and rational diet has essential importance. Principle of pharmacotherapy is a choice of optimal antidiabetics, hypolipidemics, antihypertensives and eventually anti-obesity drugs. For long-term compensation of metabolic syndrome, pharmacotherapy of associated diseases is also essential. Some medicaments can have negative effects on glycemia, blood lipids, body weight or blood pressure, so the choice of medication isn't always easy. Objectives: The main objective of this thesis includes the description of pharmacotherapy of metabolic syndrome and associated diseases in questioned patients. The research is focused on medicaments and combinations of medicaments with positive effect on metabolic syndrome components, and also on substances potentially inappropriate for patients with metabolic syndrome. The secondary...
Study of genetic and infectious risk factors in the pathogenesis of obesity in Czech adolescents.
Elblová, Lenka
4 Abstract The prevalence of obesity and its related cardiometabolic complications in children remains high across the world. Obesity is a multifactorial disease caused by interaction between genes and environmental factors. Genome-wide association studies have discovered several single nucleotide polymorphisms associated with obesity. A causal role of infection in the pathogenesis of obesity has also been considered, particularly the role of adenovirus 36 (Adv36). The aim of the Ph.D. thesis was to investigate the associations of obesity susceptibility loci (TMEM18, SH2B1, KCTD15, PCSK1, BDNF, SEC16B, MC4R, FTO) and Adv36 infection with obesity-related characteristics and complications in the Czech adolescent population. The results are described in eight publications, of which six are original papers and two are reviews. Studies were performed on a cohort of Czech adolescents recruited either from the general population (1,533 individuals from the epidemiological study) and from in-patient or outpatient weight management clinics (562 overweight/obese individuals underwent an intervention). The results demonstrated an association of TMEM18, SEC16B and FTO gene variants with obesity. Some variants of the genes involved in hypothalamic regulation of energy homeostasis − MC4R, BDNF, PCSK1 − were related to...
The role of stable analogs of prolactin-releasing peptide in obesity and hypertension.
Neprašová, Barbora ; Maletínská, Lenka (advisor) ; Poledne, Rudolf (referee) ; Rossmeisl, Martin (referee)
Anorexigenic neuropeptides have the potential to decrease food intake and ameliorate obesity and its complications such as high blood glucose or high blood pressure. However, they are not able to cross the blood-brain barrier after peripheral application. Recently, we have designed and synthesized lipidized analogs of prolactin-releasing peptide (PrRP), which resulted in stabilization of the molecule and allowed us to apply the peptide to the periphery to achieve its central biological effect, as it was demonstrated by increased neuronal activity shown by c-Fos in particular hypothalamus nuclei. The aim of this study was to choose the effective dose in acute food intake experiments and then to characterize the subchronic effect of palmitoylated PrRP analogs in mouse and rat models of obesity and diabetes. Several animal models were used: diet-induced obese (DIO) mice (C57Bl/6J), DIO Sprague-Dawley rats, and two rat models with leptin receptor-deficiency: Zucker diabetic (ZDF) rats and spontaneously hypertensive (SHROB) rats. Consumption of a high-fat diet in DIO mice and rats increased their body weight and blood pressure. Two-week intraperitoneal treatment with palmitoylated PrRP31 lowered the food intake, body weight, and returned the blood pressure to normal levels. This treatment also improved...
Využití doplňků stravy v léčbě obezity a souvisejících patologií.
KOZOVÁ, Kristýna
The popularity of dietary supplements for weight management has increased a lot in recent years. Therefore, the main purpose of this study was to review the proposed mechanism of action, effectiveness and safety profile of some dietary supplements which are commonly used in treatment of obesity and related pathologies.
Spa treatment of patients with metabolic syndrome
This diploma thesis deals mainly with patients with diagnosed metabolic syndrome disease in connection with the importance of spa treatment in Mariánské Lázně. The objectives of this work are: to find the most commonly used spa method for patients with metabolic syndrome, to find out the current lifestyle of patients with metabolic syndrome and to find out whether the health condition of patients who have undergone spa treatement was improved during their spa stay. A qualitative survey method was used to achieve the objectives. Data collection was conducted through interviews of patients with metabolic syndrome and visitors to Parkhotel Golf a.s., Mariánské Lázně. I consider the increased consumption of white bread, alcohol and cigarettes in some respondents to be the fundamental findings of my research. Most respondents do not consume vegetables in sufficient quantity, and deficiencies are also evident in dedicating to sporting activities. Information about the metabolic syndrome itself or the complications of the individual components of this syndrome is sufficient. In connection with metabolic syndrome, it was found out that not all patients who underwent spa treatment want to change their lifestyle after returning from the spa facility. Considering the findings from spa patients, I would recommend to increase the education of patients with metabolic syndrome, to emohasize to them the importance of healthy nutrition, smoking abstinence, or enough movement as the basis for preventing this disease. A lecture which has been created on the basis of interview information and is part of the supplement to this work can be used as means for patients with metabolic syndrome.
The food intake comparison of the patients with the metabolic syndrome with or without hepatosteatosis/steatohepatitis
Štičková, Zdeňka ; Macášek, Jaroslav (advisor) ; Meisnerová, Eva (referee)
Introduction: The aim of this bachelor thesis is to compare the food intake in patients with metabolic syndrome who also have Non-Alcoholic Fatty Liver Disease (NAFLD) or Non-Alcoholic Steatohepatis (NASH). The main focus of this thesis is to observe the differences in eating habits of three different groups of patients. The first group is made up of patients with metabolic syndrome with liver steatosis (NAFLD), this group also includes two patients with metabolic syndrome without steatosis. The second group are patients with steatohepatitis (NASH). The third group are patients with normal BMI as well as obese people without any metabolic disease. The thesis is divided into two parts - theoretical and practical. The theoretical part covers the definition, causes, individual constituents, complications, prevention and therapy of the metabolic syndrome, steatosis and steatohepatitis. The practical part evaluates the diet and the eating habits of people with metabolic syndrome and the differences between patients with and without steatohepatitis. Methods: Quantitative research using questionnaires. The research group were patients from the lipid and hepatological outpatient department of the IV. Internal clinic of the General Faculty hospital in Prague. The critical discussion compares the results...
The food intake comparison of the patients with the metabolic syndrome with or without hepatosteatosis/steatohepatitis
Štičková, Zdeňka ; Macášek, Jaroslav (advisor) ; Meisnerová, Eva (referee)
The aim of this bachelor thesis is to compare the food intake in patients with metabolic syndrome, who suffer from non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH). The main aim of this bachelor thesis is to find out differences in the diet of different groups of patients comprising patients with simple obesity, patients with metabolic syndrome without steatosis, patients with metabolic syndrome with steatosis and patients with metabolic syndrome complicated by steatohepatitis. This thesis is divided into two parts - theoretical and practical. The theoretical part introduces metabolic syndrome, its definition, occurrence, etiology, complications and its prevention and treatment. The topics about pathophysiology of the liver and the definition of non-alcoholic fatty liver disease or non-alcoholic steatohepatitis are also covered. Methods: The practical part is a quantitative research in the form of questionnaires made at the 4th Internal Department at the General University Hospital in Prague. The patients met the criteria of the mentioned symptoms or diseases. The thesis compares the data from literature with the responses of the patients. We explored the question of the diet composed for example by regular intake of fermented milk products, selenium, green tea or...

National Repository of Grey Literature : 81 records found   1 - 10nextend  jump to record:
Interested in being notified about new results for this query?
Subscribe to the RSS feed.