National Repository of Grey Literature 3 records found  Search took 0.00 seconds. 
Determination of vancomycin and its crystalline degradation products by HPLC
Neščáková, Monika ; Klapková, Eva (advisor) ; Kotaška, Karel (referee)
The aim of this bachelor thesis was to introduce and validate the method for the determination of vancomycin and its crystalline degradation products by high performance liquid chromatography with detection by diode-array detector. This method is able to reliably detect and distinguish the crystalline degradation products of vancomycin, which lack the necessary therapeutic effect. The long-term using of vancomycin or renal insufficiency lead to their accumulation in the patient's body. Another target of this bachelor thesis was to monitor the release profile of vancomycin concentration and its crystalline degradation products from local carrier of antibiotics that are used in some complicated orthopedic surgeries such as prevention of inflammatory infections caused by Staphylococcus aureus. We compared in vitro release of vancomycin from two bone grafts, two different bone cements and from one synthetic bone graft. The aim was to determine if the examine material releases the quantity of vancomycin, which ensure the long-term local concentrations of vancomycin higher than is the MIC of vancomycin-resistant Staphylococcus aureus (VRSA). Powered by TCPDF (www.tcpdf.org)
Investigation of the flow characteristics of bone cements during cementation.
Zezula, Miroslav ; Poláček, Petr (referee) ; Jančář, Josef (advisor)
V dnešní době se chirurgové zajímají o vliv viskozity kostních cementů na jejich penetraci do kosti při úplné kostní náhradě. Penetrace cementu závisí na jeho viskozitě, času vsunutí protézy, době tvrdnutí, atd. Viskozita je určena chemickým složením, teplotou a poměrem monomeru a prášku. V této práci bude porovnávána viskozita a penetrace vysoko- a nízko- viskózních cementů. Viskozita bude měřena dvěma modely. V prvním modelu je hrot s konstantní rychlostí vtlačován do cementu. V druhém modelu je cement vytlačován z kapiláry konst. rychlostí. Penetrace cementu po vstříknutí do kosti bude měřena pomocí rentgenu.
Preliminary study using pulsating water jet for bone cement demolition
Hloch, Sergej ; Kloc, J. ; Foldyna, Josef ; Pude, F. ; Smolko, I. ; Zeleňák, Michal ; Sitek, Libor ; Hvizdoš, P. ; Monka, P. ; Monková, K. ; Kozak, D. ; Stoić, A. ; Sedmak, A. ; Milosevic, M. ; Lehocká, D. ; Mihalčinová, E.
The paper deals with the study of using the selective property of ultrasonic pulsating water jet for the disintegration of bone cement which creates the interface between femoral stem and trabecular bone tissue. For investigation, commercial bone cements were used. Bone cements were tested by nanoindentation in order to review their mechanical properties. A representative sample Palacos R+G was selected for disintegration of bone cement. Bone cements samples fixed between two plexiglasses were disintegrated using ultrasonic water jet and water jet generated by self-resonating nozzle at the pressure level of 20 MPa. Visualisation of bone cement demolition was provided with high speed 1 kHz cameras with two led pulsed sources. Potential were observed for using of pulsating water jet for bone cement demoliton during femoral stem extraction.

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