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National Repository of Grey Literature

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Nutritional problems in patients with chronic graft-versus-host disease after allogeneic transplantation of hematopoietic cells Michková, Petra ; Šťastná-Marková, Markéta (advisor) ; Novák, František (referee) Introduction: Graft versus host disease (GVHD) is a serious medical complication following allogeneic hematopoietic cell transplantation (allo HSCT). It causes immunodeficiency and several organ damage and decreases survival time at two years after a transplantation. A nutritional intervention should be applied just before the transplantation, because a nutritional status significantly influences the post-transplant complications. A risk of malnutrition or metabolic syndrome can be assessed by several markers. A combination of laboratory, anthropometric, biometric and physical data is suitable for this purpose. In addition, a subjective questionnaire regarding eating habits and physical activity of the patients can be used. Objectives: This thesis deals with the patients with chronic GVHD (cGVHD) following the allo HSCT. The objective was to describe a nutritional status of the patients, to find out in which way a long-term immunosuppressive treatment affects a body composition and to describe the eating habits and the physical activity of these patients. Methods: 31 patients with GVHD and 24 patients after allo HSCT without GVHD participated in the research. A body composition (using bioelectrical impedance) and selected laboratory parameters in patients were assessed. A subjective health... Detailed record

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