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Annes, Extension and Building Adjustment of the Building House Neumannova in Brno, Preparation and Realization of Buildings
Martincová, Michaela ; Patloka, Jiří (referee) ; Šlanhof, Jiří (advisor)
The thesis deals with the technological stage of the rough construction of the annex and the reconstruction of the apartment building on Neumannova Street in Brno-Pisárky. These are earthworks, rough substructure, rough construction, demolition work, and some of the finishing work. The diploma thesis deals with the design of the work process of the works, the design of the machine assemblies, the studies of the implementation of the main technological stages, the preparation of the budget item, the time schedule, the time and the financial plan of the object, the control and testing plan, the material assurance plan and the transport relations. Further, the design of the building facility is processed and a technical report of the building facility is made.
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Car service
Diatel, Bohumil ; Kozubíková, Ivana (referee) ; Matějka, Libor (advisor)
The subject of this diploma thesis is a layout of car service object in Brno – Horní Heršpice, Železná street. The building is designed as four-floor with flat - cascaded roof, which will be partially used also like a terrace. The object is intended for repairs and servicing of the trucks and buses. Inside the building are situated also offices, training room and temporary accommodation for the drivers. Supporting structure of the building is composed by ferroconcrete prefabricated shell, which horizontal supporting structure is composed by ferroconcrete pre-stressed panels spiroll. The curtain enclosure wall is designed from Sendwix system line-sand bricks with the outer thermal insulation. A building plot is flat. A part of the layout is also thermal and technical, acoustic and fire safety assessment. This diploma thesis contain also five specializations – layout of ferronconrete pre-stressed girder, layout of steel shelter, layout of construction basing, scheme of the overall heat output of the building and sewerage layout.
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Building survey and evaluating the state of construction
Broďák, Marek ; Komárková, Tereza (referee) ; Heřmánková, Věra (advisor)
This diploma thesis is focused on building survey and evaluating the state of existing constructions. In theoretical part are described the process of evaluating the state of existing constructions and selected diagnostic methods. The practical part is dealing with performed structural and technical survey of industrial object including evaluation of the strength of concrete and verification of the reinforcement. The last part is focused on a static assessment of selected supporting element of the structure.
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Effect of sub-micrometer structural features on rheology of polymer nanocomposites
Lepcio, Petr ; Chodák,, Ivan (referee) ; doc.Ing.Marián Lehocký, Ph.D. (referee) ; Jančář, Josef (advisor)
Polymerní nanokompozity (PNCs) mají slibnou budoucnost jako lehké funkční materiály zpracovatelné aditivními výrobními technologiemi. Jejich rychlému rozšíření však brání silná závislost jejich užitných vlastností na prostorovém uspořádání nanočástic (NP). Schopnost řídit disperzi nanočástic je tak klíčovým předpokladem pro jejich uplatnění ve funkčních kompozitech. Tato práce zkoumá přípravu polymerních nanokompozitů v modelové sklotvorné polymerní matrici roztokovou metodou, technikou schopnou vytvářet prostorové uspořádání nanočástic řízené strukturními a kinetickými parametry přípravného procesu. Prezentované výsledky popisují rozdíly mezi změnami rheologického chování roztoku polystyrenu při oscilačním smyku s vysokou amplitudou (LAOS) vyvolanými nanočásticemi. Výsledky vedou k závěru, že vysoce-afinní OP-POSS nanočástice při nízkých koncentracích dobře interagují s PS a tvoří tuhé agregáty, zatímco nízko-afinní OM-POSS nanočástice za těchto podmínek neovlivňují deformační chování polymerních řetězců. Dále byla pozornost zaměřena na vliv použitého rozpouštědla na uspořádání nanočástic v SiO2/PMMA a SiO2/PS nanokompozitech, který je v literatuře prezentován jako parametr řídící prostorové uspořádání nanočástic v pevném stavu. Důraz byl kladen na kvalitativní rozdíly mezi „špatně dispergovanými“ shluky nanočástic, které byly na základě rheologie a strukturální analýzy (TEM, USAXS) identifikovány jako polymerními řetězci vázané nanočásticové klastry a dva typy agregátů, jeden termodynamického a druhý kinetického původu. Jednotlivé druhy agregátů se vyznačují odlišnými kinetikami vzniku a rozdílnými vlastnostmi jak mezi sebou, tak v porovnání s dispergovanými nanočásticemi. Pozorované typy disperze nanočástic byly kvantitativně posouzeny podle svých rheologických vlastností během roztokové přípravy, podle kterých byla vyhodnocena míra adsorpce polymeru na povrch nanočástic a atrakce ve vypuzeném objemu. Výsledky byly porovnány s teorií PRISM. Důležitost uspořádání nanočástic byla demonstrována na porovnání teplot skelných přechodů různých struktur při stejném chemickém složení.
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INFLUENCE OF INFORMATION SYSTEM IMPLEMENTATION ON CHANGES IN STRATEGIC GOALS AND IN ORGANIZATIONAL STRUCTURES
Hajkrová, Romana ; Bartoš, Vojtěch (referee) ; Dvořák, Jiří (referee) ; Kubík, Josef (referee) ; Němeček, Petr (advisor)
The aim of the dissertation is to monitor the process of information system implementation and its impact on the changes in the organizational structure and in strategic goals. Achieving this task is based on monitoring and evaluating the process of implementing the information system, on monitoring its impact on factors which affect the necessary changes in the organizational structure of enterprises and affect the strategic objectives of the enterprise. The data will be obtained on the basis of scientific methods designed for this purpose and they will be divided into parts of a questionnaire survey and of a managed interview. Within the framework of the questionnaire, the entire process will be evaluated in three dimensions: level of management, user level and the process level. The result of the dissertation will be either a confirmation or a refutation of the hypothesis related to the impact of IS implementation on the strategic objectives and on the organizational structure of the company. On this basis a defined procedure will be created for the implementation of information system monitoring and regulating changes in the strategic objectives and in the organizational structure. This procedure can serve as a guide for general use within companies, and on the basis of its results a decision will be made as to whether it is possible to use it in practice.
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Structural and pharmacological determinants of NMDA receptor channel gating
Ladislav, Marek ; Krůšek, Jan (advisor) ; Bendová, Zdeňka (referee) ; Zemková, Hana (referee)
N-methyl-D-aspartate receptors (NMDARs) are heterotetramers containing two obligatory glycine-binding (GluN1) and two glutamate/glycine-binding (GluN2/3) subunits. These receptors mediate excitatory synaptic transmission in the central nervous system and play a key role in high order neuronal processes as a learning and formation of memory. It has been shown that dysregulation of NMDARs is involved in the pathophysiology of neurological and psychiatric disorders. Each receptor is composed of four protomers exhibiting a conserved domain organization. The most distal part to the cell membrane is the amino-terminal domain that is linked to the ligand binding domain (LBD), which is connected to the pore-forming transmembrane domain (TMD) communicating with the intracellular carboxy-terminal domain. LBD and TMD are connected via three polypeptide chains - linkers. Channel opening is the key step in the NMDAR gating that allows the flux of ions across the membrane. The energy of agonist binding-evoked conformational changes is transferred via linkers to M3 helices forming an ion channel. The rearrangement of M3 helices in activated receptor makes the central cavity of the channel accessible. The details of energy transfer are not yet fully characterized, although accurate knowledge of the receptor gating...
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Prevention of socially undesirable phenomenon in the selected region
MĚCHÁČKOVÁ, Žaneta
This bachelor thesis concerns the ways of prevention of socially pathological phenomena realisation in Pribram region. Theoretical part is dedicated to definition of particular socially pathological phenomena and the ways of socially pathological phenomena prevention including concerned institutions at the national level are discussed. In practical part qualitative methodology is used to capture the structure and cooperation of institutions that are concerned in socially pathological phenomena prevention in the dedicated region including the analysis of concrete prevention programmes executed by organizations of communication partners.
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Developement of work on structure in kindergarten
Horáková, Vendula ; Kaslová, Michaela (advisor) ; Slezáková, Jana (referee)
Abstract The Master thesis "Developement of work on structure in kindergarten" aims to find out which structures are percieved well by the Czech child of the last year of pre-school and in which types of percieved structures there are difficulties and to characterize these difficulties. Qualitative research was used to achieve the goal. The thesis deals with two types of structures, one direction or simultaneusly two directions structure. The partial aim is to describe (on the basis of acquired data and experience) recommendations and offer in practice proven appropriate activities that would precede the activities in last year of pre- school eductaion. A series of tasks has been created to test how the child works with a regular rhythm structure in one and two directions. At the same time, I watched if it is easier for the child to fill in these worksheets or work with small 3D material in given directions. In addition to the observation method, interviews with children were conducted and data recordings were added to the analysis. The evidence obtained showed that the preschool children in the last year of the kindergarten understands the structure more easily in one direction and is better oriented in the horizontal position than in the vertical or both directions simultaneously. This may be due...
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The analysis of structural details of the NMDA receptor
Radilová, Kateřina ; Balík, Aleš (advisor) ; Jakubík, Jan (referee)
NMDA receptor is necessary for excitatory transmission in the central nervous system. Altered funtion of the NMDA receptors is associated with many neurodegenerative and neuropsychiatric diseases. All available crystal structures of the NMDAR meant great shift towards our understanding of details of the receptor and its function. Unfortunately, these up- to-date available structures present only certain functional states of receptors and also a few structural data are still missing. For complete comprehension of the process of activation and deactivation of NMDA receptors, we need to supplement the current information with more data. The aim of this thesis was to employ a combination of different approaches (computational modelling, cloning, biochemistry, protein expression and purification and mass spectrometry) to obtain new structural data, by which we would be able to fill in the gaps in current receptor models, especially at various functional states of the receptor. Key words: NMDA receptor, glutamate receptor, computational modelling, structure, cloning, protein expression
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