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The occurence of pharmaceuticals in the environment I.
Tkáčová, Gabriela ; Vytlačilová, Jitka (advisor) ; Opletal, Lubomír (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany Candidate: Gabriela Tkáčová Supervisor: RNDr. Jitka Vytlačilová, Ph.D Title of diploma thesis: The occurence of pharmaceuticals in the environment I. Drugs are biologically active substances used for treatment and prophylaxis of human and animal illnesses. Some drugs, however, remain biologically active even after they are excreted from the organism. By various means these substances can appear in the environment and can be detected in wastewater, surface water, seawater, groundwater, drinking water, sediments and soil. Chronic presence of low concentrations of drugs in the environment can negatively affect non-target organisms. Aim of this diploma thesis is to study presence of SSRI, statins and hypoglycemic drugs in the environment. Drugs from these farmacodynamic groups were detected in the environment in concentrations ranging from ng/l to μg/l. Selected drugs from SSRI group were fluoxetine, citalopram, fluvoxamine, sertraline, paroxetine and escitalopram. In water samples they were detected in concentration ranging from tens to hundreds ng/l, they were also detected in soils and sediments. Toxicity for water biota was also proven. Fluoxetine caused changes in secondary sexual characteristics of fish...
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The occurence of pharmaceuticals in the environment II.
Olivová, Tereza ; Vytlačilová, Jitka (advisor) ; Sklenářová, Hana (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany and Ecology Candidate: Tereza Olivová Supervisor: RNDr. Jitka Vytlačilová, Ph.D Title of diploma thesis: The occurrence of pharmaceuticals in the environment II. Pharmaceuticals are biologically active substances used for treatment or prevention of human and animal diseases. Some of these substances remain active even after being excreted from an organism and they can enter the environment. The residues of pharmaceuticals are present not only in rivers, but also in sea, groundwater and in soil, into which the contaminated water and manure are applied. The concentration of pharmaceuticals in water and in soil differ from place to place (it is higher e. g. in close proximity of sewage treatment plants) and from season to season (it depends on levels of precipitations and sunshine). Nowadays, thanks to sensitive analytical methods it is not a problem to detect these xenobiotics even in very small amounts, in which they usually occur in nature (usually in order of units or tens of ng/l or ng/g). However, even these low concentrations might have a negative impact on the life of non-target organisms (e. g. reproduction disorders) and therefore, the calculations, which measure the lever of risk of particular...
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