|
|
Information Awarness and Experience of Common People with Food Allergy
Stropková, Romana ; Hošťálková, Monika (advisor) ; Strnadová, Alice (referee)
The bachelor thesis is focused on the problems of the food allergies. The aim was to discover how much the population is informed in this field, if the population has experienced the food allergies, having found the symptoms present on themselves or their friends, family. And finally the awareness of these allergies in a family taking care of an allergic person is studied. In the theoretical part the definitions of the food allergies and similar reactions are explained. It is followed by anatomical and physiological descriptions of digestive and immune systems which are closely related to the food allergy. The causes and symptoms of the food allergies, diagnostics, treatment and prevention are integral to the theoretical part. The importance of probiotics and prebiotics which differs in scientists' opinions and in results of scientific studies is also studied. In the end of this chapter a new antigen and the education of the general public are mentioned. In the empirical part the characteristics of research assignment and methods of the research are described. I chose a questionnaire as a method for data collection. I deal with the results of the questionnaires in this part too. Research shows that the majority of respondents knows what the food allergy is and have an idea of its causes and...
|
|
|
Leniency programme in competition law
Duch, Martin ; Horáček, Vít (advisor) ; Klee, Lukáš (referee)
This thesis deals with a legal framework of leniency programme. The program provides imunity or fine reduction from government penalties to the first member of a cartel in exchange for cooperation. The aim of the thesis is to evaluate effectiveness and functioning of the Czech and European leniency program, effects in practice and current challenges the program is facing. In introduction thesis deals with general requirements for an effective leniency program, further with development of the program in the EU and the Czech Republic with focus on progress towards more efficient, transparent and attractive system and application practice of the Commission, and. Office for Protection of Competition. It briefly introduces the European Competition Network and Model Leniency programme. Another part deals with the private enforcement of competition law in context of the current case law concerning access to the file and protection of leniency materials.
|
|
|
Autophagy in the immune system
Vávra, Dan ; Černý, Jan (advisor) ; Janštová, Vanda (referee)
Autophagy is an essential, homeostatic process - survival mechanism that protects cells by various ways: cells break down their own components to recycle nutrients, remodel and dispose unwanted cytoplasmic constituents. Autophagy is involved in the degradation of long-lived proteins and entire organelles, but paradoxically, considering important prosurvival functions, autophagy may be deleterious. It plays an important role during development, tumor suppression, immunity and is required for the adaptation to environmental stresses such as starvation. Recent studies indicate, that autophagy is a central player in the immunological control of bacterial, parasitic and viral infections. The process of autophagy may degrade intracellulal pathogens. This work describes the mechanism of autophagy and highlights the role of autophagy in innate and adaptive imunity, summarizes some advances in understanding the functions of autophagy and its possible roles in the causation and prevention of human deseases.
|
|
|
Study of inflammation using epithelial cells
Majerová, Barbora ; Hodek, Petr (advisor) ; Koblihová, Jitka (referee)
The human respiratory system is in constant contact with heterogeneous agents from the environment. There must be effective mechanical lung barriers and sufficient immune protection due to continuous deposition of various substances in the respiratory system. The mutual balance between the mechanisms of natural and adaptive immunity of the lungs is essential for destruction of infectious agents without initiation of inflammatory response. Overreaction of the immune system of the lungs may lead to the production of various inflammatory mediators and cytokines such as interleukins IL-1, IL-6 and IL-18. When determining the immunogenicity of a substance, it has to be exposed to lung epithelial cells, and then the concentration of cytokines produced is measured. To determine the immunogenicity of mammalian immunoglobulin G and chicken immunoglobulin Y the subsequent twenty-four hour exposure to A549 lung cancer cell line was made. Concentration measurement of cytokines IL-1 and IL-6 was performed using Luminex method, which pointed out the immunogenicity of goat immunoglobulin G and certain chicken immunoglobulins Y.
|
|
|
The leniency programme in the european and czech cartel law
Tučková, Zuzana ; Svoboda, Pavel (advisor) ; Šmejkal, Václav (referee)
The aim of this thesis is to introduce the concept of the leniency programme and to describe its development and current legal regulation in the European Union and the Czech Republic, to evaluate its rules, its effectiveness and morality. The thesis also explores the relationship between leniency programme and other instruments in antitrust law enforcement. Leniency programme lies in granting full or partial immunity from sanction to the member of a cartel that reports the existence of this cartel to the antitrust authority. The thesis describes the key features of an effective leniency programme and compares these general postulates with real facts from the practise of the European Commission and the Office for the Protection of Competition. The thesis continues with pointing out the differences between European Commission notification issued in the years 1996, 2002 and 2006 and it describes how the programme works nowadays. It also focuses on the cases in which the Commission used the leniency programme. It also deals with the issue of European Competition Network and its Model Leniency Programme. Then it describes the leniency programme in the Czech Republic and the decisions by the Office for the Protection of Competition on the basis of leniency application. The comparison of Czech and...
|
|
|
Recombinant vaccinia virus for cancer therapy, the analysis of biological and biochemical features.
Žůrková, Kamila ; Němečková, Šárka (advisor) ; Forstová, Jitka (referee) ; Trejbalová, Kateřina (referee)
151 8 SUMMARY Recombinant vaccinia virus has been used for elicitation of the immune response against expressed heterologous proteins which has led to protection of the host organisms against the agents producing that antigen (viruses, cancer cells). In our laboratory, we designed and evaluated several vaccines against cancer caused by human papillomavirus type 16 (HPV16). Vaccinia viruses derived from replication competent strain P13 or attenuated MVA were used for construction of recombinant viruses expressing HPV16-E7 in highly immunogenic fusion construct SigE7LAMP. Recombinant viruses were used both in prophylactic and therapeutic settings in mouse tumor models using TC-1 or TC-1/A9 cells. The genes encoding stimulatory cytokines GM-CSF or Flt3 ligand were inserted into the above viruses to support the immune system and to potentiate the anticancer response. Tumor microenvironment was modified using the recombinant viruses expressing both the E7 gene and soluble receptor for TGF-β which should decrease the inhibition of immune system caused by tumor TGF-β cytokine and elicit the response against tumor cells. Intratumoral or intraperitoneal administration of viruses enhanced anticancer response in mice, the viruses expressing Flt3 ligand induced the proliferation of E7- specific cytotoxic T lymphocytes....
|
|
|
Significance of prolactin as peripheral cytokine in dysbalance of immune system
Janatová, Kateřina ; Černá, Marie (advisor) ; Holáň, Vladimír (referee)
Background: Interactions between the neuroendocrine and immune system play an importatnt role in maintaining homeostasis. This communication is mediated by cytokines, neurotransmiters and hormones through endocrine, paracrine and autocrine signaling. Prolactin (PRL), hormone of anterior pituitary, is produced by a number of other tissues and cells of immune system. On periphery, PRL is cytokine. Sepsis is an inflamatory response of the organism to severe infection, Th1 immune response is activated and PRL could participate in it. Toll-like receptors (TLR) play a key role in a recognition of bacteial components and mediate a systemic response (with PRL secretion) during infection. It is supposed that activated immune system leads to increasing of PRL, TLR2 and TLR4 gene expression. We detected PRL, TLR2 a TLR4 mRNA levels in monocytes from patiens with system inflammation. We studied influence of single nucleotide polymorphism (SNP -1149 G/T) in PRL gene promotor, it supposed that G allele increases PRL expression. Materials and Methods: For the pilot study 30 patients diagnose with severe infectious event. Collectoin of patiens blood samples was performed consequently three times. Control group comprised 40 healthy individuals. One blood sample was taken from each healthy subject. For testing of...
|
|
|
Sources of food allergens and their health significance
Novotná, Tereza ; Faměra, Oldřich (advisor) ; Dana, Dana (referee)
In the whole world, 2-8% of the adult population suffers from a food allergy. The number of children is even much higher in this respect, but their allergies very often disappear with age. Differences in the prevalence of allergies lie in age, geographical conditions and lifestyle.
By food allergy, we understand a reaction catalysed by the immunity system. Pathological symptoms will appear in an individual after they have been exposed to allergy inducing food which starts an immunity reaction. Allergy is a pathological state based on a hypersensitive reaction caused by an allergen of a foreign character.
Food allergens are able to cause atopic or non-atopic reactions among which belong the allergic rhinitis, allergic asthma, atopic dermatitis, allergic gastroenteropathy, anaphylactic shock or angioedema. The symptoms may range from light to very sever and in cases of severe reactions, it is necessary for the individual to avoid the allergy inducing food completely.
Among allergy inducing food may belong all food which contains protein. Reactions manifest themselves to a different degree and by a different symptom in every individual.
The diagnostic methods are demanding and not always accurate. Therefore, it is necessary for the patient to keep careful records of the food they consume. Almost all food allergens are proteins, but it is the protein parts contained in food, that induce allergy. However, there are some groups of food which cause allergic reaction more frequently than others. Among these belong the cow milk proteins, fresh fruit, eggs, fish, crustaceans and peanuts.
It is also necessary to take cross allergies between both related and unrelated food into account, since they cause considerable health issues, for example, the oral allergy syndrome.
Prevention of a food allergy is possible only by complete omission of allergy inducing food from the diet of the individual.
|
|
|
Immunity of Members of Parliament in Selscted States: Study 1.175
Medková, Eva ; Nemeth, Marek ; Syllová, Jindřiška
V obecném úvodu je popsán institut parlamentní imunity jako jeden z nástrojů ochrany nerušené činnosti zákonodárného sboru. Jeho historické kořeny sahají již do středověku, kde bylo nezbytné chránit nově se vytvářející stavovská shromáždění před zásahy tehdy mocných panovníků. Postupem historického vývoje se institut rozpadl na dvě rozdílné a přesto propojené části, na neodpovědnost poslanců a na jejich nestíhatelnost. Zatímco neodpovědnost chrání proti stíhání za hlasování a některé projevy, které v parlamentu činí, často v rámci výkonu svých povinností, nestíhatelnost zabezpečuje, že je poslanec chráněn před zákonným stíháním trestného činu, správního deliktu či občanskoprávního aktu. Zatímco právní úprava neodpovědnosti je ve zkoumaných zemích více či méně obdobná (doba jejího trvání bývá neomezená, možnost jejího odejmutí je ve většině případů vyloučena), je právní úprava nestíhatelnosti značně odlišná. Jednotlivé úpravy (až na drobné výjimky) spojují dvě věci. První z nich je prolomení imunity ve smyslu nestíhatelnosti poslance v případě, že je přistižen při činu (někdy úplné jindy částečné), druhou je stanovení doby, na kterou se nestíhatelnost vztahuje (jde v naprosté většině případů jen o dobu výkonu mandátu poslance). Jsou však i takové země, které nestíhatelnost neupravují a staví tak poslance ve vztahu k trestnímu a příp. i správnímu stíhání naroveň běžnému občanovi. S jednotlivými právními úpravami rozsahu poslanecké imunity, které ve zkoumaných zemích platí, se může čtenář seznámit v přehledné tabulce.
Fulltext:  PDF
|
|
|
Allergen-specific immunotherapy from the perspective of nurses.
BEJTICOVÁ, Lenka
The subject matter of the bachelor thesis is specific allergen immunotherapy from the perspective of nurses. The work is divided into theoretical and practical parts. The concepts associated with the topic are explained in the theoretical section of the thesis. These concepts are as follows: allergy, allergen, immunity, sensitization, anaphylaxis and specific allergen therapy. Basic allergic diseases, work and role of the nurse are also described in the theoretical part. The practical part of the thesis contains four goals: the first three goals relate to nurses working in allergology ambulances; the fourth goal is focused on the needs of patients undergoing treatment with specific allergen immunotherapy. The first goal was to find out nurses' knowledge related to the specific allergen immunotherapy, second one dealt with the skills of nurses in the administration of specific allergen immunotherapy and the patients education process realised by nurses in allergology ambulances represented the third goal of the thesis. The fourth objective focused on the needs of patients undergoing treatment with specific allergen immunotherapy. To achieve these objectives the qualitative inquiry method of semi-structured interviews and observations were used. The research group consisted of four nurses working in private allergology ambulances in South Bohemia and four patients undergoing treatment with specific allergen immunotherapy. The research showed that nurses working in allergology ambulances have enough knowledge and skills in administration of specific allergen immunotherapy. The primary needs of patients can be determined as the need to be informed and to perceive the positive attitude of nurses and physicians to the patients.
|
guest ::
