National Repository of Grey Literature 12 records found  1 - 10next  jump to record: Search took 0.01 seconds. 
Endokrinní onemocnění vyskytující se u fretek
Bulvová, Anna
The diploma thesis entitled “Endocrine Diseases in Ferrets” deals with the evaluation of the current situation of endocrine diseases in ferrets from the Czech Republic and abroad with a focus on hyperadrenocorticism and insulinoma. The theoretical part of the thesis describes the meaning and history of ferrets, presents ferret health issues and summarizes current knowledge of selected endocrine diseases in ferrets. The practical part of the thesis includes the evaluation of a survey from 235 respondents from 39 states, of which 142 breeders encountered some endocrine disease. Information on 93 individuals with insulinoma and 89 individuals with hyperadrenocorticism is also processed. Data on sex, age, diagnosis, neutering, treatment, etc. are assessed. From the answers obtained, it was also possible to deduce differences between the Czech Republic and abroad, as up to 20.1 % more breeders abroad encountered some ferret endocrine disease.
Needs of patients with thyroid disease
HANUSOVÁ, Kateřina
This bachelor thesis deals with the needs of patients with thyroid disease. The work is divided into two parts, theoretical and practical. Thyroid diseases include goiter, inflammation, tumors, hypothyroidism and hyperthyroidism. This work is focused on the needs of patients with hypothyroidism and hyperthyroidism. The two diseases differ in thyroid function, which is reduced in hypothyroidism and increased in hyperthyroidism. Both diseases are accompanied by many non-specific symptoms that occur in all systems. The treatment of the disease takes place in hypothyroidism in the replacement of thyroid hormones and in hyperthyroidism either also in the replacement of hormones or it is solved operatively or with the help of radioactive iodine. It is important to adhere to the treatment, as even in these two diseases, symptoms may increase and subsequent myxedema coma or thyrotoxic crisis may occur, which are life-threatening conditions. In the theoretical part, we also deal with the hierarchy of needs, because the nursing process is derived from this knowledge. The disease can affect the patient's needs in some way and in case of their dissatisfaction, the patient suffers in the physical, mental or social area. In the practical part of the bachelor thesis we dealt with qualitative research. This study consisted of ten probands treated with either hypothyroidism or hyperthyroidism. The method of semi-structured interview was chosen for data collection, which was used in communication with probands suffering from thyroid disease. The interviews were formulated on the basic of the set goal: To map the needs of patients with thyroid disease. The research was conducted at home. The results we obtained from the interviewees through interviews were divided into several categories and subsequently processed. According to our research, a different need is important for each patient. However, I would like to note that even after using the medication, some respondents still struggle with fatigue, which they try to overcome to a certain extent, but even so they are sometimes forced to succumb to fatigue and go to rest during the day. I would also like to mention the reduced tolerance of the warm environment, which appeared in some respondents, and even after the use of medication in patients did not disappear. Finally, I would like to point out that, according to our research, some respondents are afraid of pregnancy due to their illness, which is likely to limit them in the future. This work will serve students to obtain new information about the disease and could also serve as a source of information for newly diagnosed patients.
Foods affecting function of the thyroid glande
Ciprová, Markéta ; Chrpová, Diana (advisor) ; Ezechiášová, Věra (referee)
6 Abstract Basis: This master's thesis deals with the issue of foods affecting thyroid function. The thyroid gland is an important endocrine organ involved in many bodily processes, it is completely dependent on external iodine intake and at the same time it is susceptible to some naturally occurring antinutritive substances. The main subject of research were therefore the sources of iodine and strumigenic substances in the diet and their occurrence in the diet of adults. The main sources for this thesis include the monograph Thyroid Gland, organized by Zdeňka Límanová, websites of professional institutions of the Ministry of Health of the Czech Republic and the World Health Organization and of course current studies dealing with this issue available in world health databases. The topic was chosen by the author on the basis of finding current topics in the field of nutrition, that have not yet been reserched by other students in the Nutrition Specialist field of study in recent years. Aims: The primary goal of the master's thesis was to examine and process current issues of thyroid function, especially in connection with the consumption of foods that affect this function. For this purpose, a questionnaire was compiled to obtain sufficient base and data to determine the average consumption of iodine and...
Economic aspects of screening for thyroid disease in pregnancy and in women with fertility disorders
Bartáková, Jana ; Jiskra, Jan (advisor) ; Zamrazil, Václav (referee) ; Smutek, Daniel (referee)
The incidence of thyroid diseases in pregnancy in the Czech Republic reaches 10- 15%. Emphasis on early diagnosis and treatment is laid not only during pregnancy but also in the time preceding conception due to the impact of thyroid diseases on fertility, the course of pregnancy, birth and fetal development. The aim of the dissertation was to assess the effectiveness and economical aspects of screening for thyroid disease in pregnancy and in women with fertility disorders in the conditions of the Czech Republic. The dissertation consists of four published studies. The first study is a prospective cross-sectional study of 200 positively screened pregnant women. In the study we come to conclusion that pregnant women who are at high- and low-risk for thyroid disease have similar clinical and laboratory characteristics and screening, currently focused only on risk groups, is ineffective. The second study of 5 223 pregnant women is a case-control study. We find that the age of women over 30 cannot be regarded as a risk factor for thyroid disease in pregnancy, although addition this age criterion to the case-finding screening strategy improve its efficiency and ATA (American Thyroid Association) include it in their guideline 2011. The third publication is a retrospective cross-sectional study of 188...
How does the fluid intake affect the gastrointestinal absorbtion of levothyroxine.
Kročová, Radka ; Krátký, Jan (advisor) ; Hána, Václav (referee)
Thyroid diseases belong among the most common endocrinopathies, and, therefore, thyroid hormones are among the most commonly prescribed drugs in the Czech Republic, as well as in the world. Even though untreated thyropathies may cause several health complications for the patients, poorly administered treatment can also hurt the health of the individual. Several factors make the treatment difficult. A type of fluid used to ingest the drug belongs among such factors, and it represents the focus of this Master thesis. As is indicated by its title, the thesis focuses explicitly on the gastrointestinal absorption of levothyroxine after being ingested with water, black tea or cow's milk. The thesis was aimed at determining whether and to what extent, if any, the fluids may influence the gastrointestinal absorption of the drug. Based on this premise, research was conducted with six test subjects who underwent a relatively challenging absorption test with four blood samples taken over six hours. The data set (altogether 56 samples taken from all test subjects) had revealed that the gastrointestinal absorption of levothyroxine reached its maximum values when the drug was ingested with water. The other test fluids impair the bioavailability of L-thyroxine, and patients should wait to indulge in them at least...
Thyroid hormones, their importance and exposure to cold
Špínová, Šárka ; Žurmanová, Jitka (advisor) ; Krulová, Magdaléna (referee)
Thyroid hormones are essential mainly for prenatal development and they maintain the homeostasis of many organs and body processes in adulthood. Therefore, the correct function of the regulatory axis between the hypothalamus, pituitary gland and thyroid gland is very important. Lack of these hormones is manifested, for example, by the formation of goiter, cretenism and bradycardia, excess in weight loss, ophthalmopathy, excessive sweating, tachycardia and also goiter formation. A serious problem is also the mutation of thyroid hormone receptors in target tissues. It causes nervous system disorders, hearing, vision, digestive system, incorrect cardiac function, delayed growth and mental development. Thyroid hormones are essential for the formation and activation of brown adipose tissue. This, together with the shivering thermogenesis of skeletal muscle, is involved in facultative thermogenesis, helping homoeothermic mammals to maintain a constant body core temperature. In addition, brown adipose tissue is an important endocrine organ that secretes active substances called batokines upon cold activation. Batokines have beneficial effects in the treatment of obesity, diabetes and cardiovascular disease. So we can assume that cold adaptation could effectively help in the treatment of civilization...
Weight and BMI in relation to the dose of levotyroxin of patients with hypothyreosis
Radiměřská, Veronika ; Jiskra, Jan (advisor) ; Ježková, Jana (referee)
The objective of this study was to define if there is a mutual influence between the daily dose of levothyroxine, positivity/negativity of thyroid antibody, BMI, waistline, hip measurement and other anthropometric parameters. It was also to analyze if the daily dose of levothyroxine is being influenced by degree of hypothyroidismimportance. Methodology: There were 44 patients examined having hypothyroidism and who have been cured with levothyroxine so that their thyroid function has been normal at the time. I have examined those patients' body height, weight, BMI, waistline and hipline. Under the supervision of the medicine doctor I used records available for each of patients regarding concentration of TSH, TPOAb and TgAb, which were defined with patients' blood by a method of immunoassay. Results: The average daily dose of levothyroxine in all patients sample has showed a positive correlation with BMI (Spearman rho coef. 0,429, P value=0,004) and with waistline of women (Spearman rho coef. 0,332, P value=0,028). The concentration of thyroidantibody did not show a statistical relevance regarding the dependence with the dose of levothyroxine, BMI or other anthropometric parameters.The highest average daily dose of levothyroxine was confirmed for examined patients after total thyroidectomy (median of...
Economic aspects of screening for thyroid disease in pregnancy and in women with fertility disorders
Bartáková, Jana ; Jiskra, Jan (advisor) ; Zamrazil, Václav (referee) ; Smutek, Daniel (referee)
The incidence of thyroid diseases in pregnancy in the Czech Republic reaches 10- 15%. Emphasis on early diagnosis and treatment is laid not only during pregnancy but also in the time preceding conception due to the impact of thyroid diseases on fertility, the course of pregnancy, birth and fetal development. The aim of the dissertation was to assess the effectiveness and economical aspects of screening for thyroid disease in pregnancy and in women with fertility disorders in the conditions of the Czech Republic. The dissertation consists of four published studies. The first study is a prospective cross-sectional study of 200 positively screened pregnant women. In the study we come to conclusion that pregnant women who are at high- and low-risk for thyroid disease have similar clinical and laboratory characteristics and screening, currently focused only on risk groups, is ineffective. The second study of 5 223 pregnant women is a case-control study. We find that the age of women over 30 cannot be regarded as a risk factor for thyroid disease in pregnancy, although addition this age criterion to the case-finding screening strategy improve its efficiency and ATA (American Thyroid Association) include it in their guideline 2011. The third publication is a retrospective cross-sectional study of 188...
Embryotoxicity test of thyroxine on chick embryo.
Petrušková, Michaela ; Peterka, Miroslav (advisor) ; Novotná, Božena (referee)
Thyroxine is the main thyroid gland's hormone. The state, when the thyroid gland does not produce enough of it into the bloodstream is called hypothyroidism. Hypothyroidism is related with several health complications; therefore it is required to take replacement therapy in adequate doses. Concerning pregnant women, it is important especially to keep the blood level of thyroxine in the normal, because increasing or decreasing of it, has an adverse effect on the health of the mother and also on the normal child development. The objective of my thesis was to describe malformations spectra of thyroxine, to find out the beginning of its embryotoxicity dose range for chick embryos, and recalculate this value for human embryos, allowing us to decide, if the level of thyroxine was increased by a replacement therapy, this could be embryotoxic for human. The experimental part of my work was to search an alternative method for testing embryotoxicity on chick embryos in ovo - CHEST, testing of embryotoxic potential of the thyroxine. Embryotoxicity is a feature of the external factors affecting the embryo, it may manifest as lethality, growth retardation, and teratogenicity; which is an ability of the external factor to induce the developmental defect. The most common manifestation of embryotoxicity in this...
Changes of thermal thresholds in patients treated with hypothyroidism.
Zůna, Miroslav ; Marčišová, Hana (advisor) ; Čakrt, Ondřej (referee)
Diplomová práce Miroslav Zůna 3 Author's first name and surname: Miroslav Zůna, BA. Title of the master thesis: Changes of thermal thresholds in patients treated with hypothyroidism. Department: Department of Physiotherapy and Sports Medicine Supervisor: Hana Marčišová, MA. The year of presentation: 2013 Abstract: Disorders of thyroid gland together with diabetes are most common endocrine diseases in Czech Republic and worldwide, too. Myopathy and neuropathy, caused by reduced amount of thyroid hormones, are mentioned in current literature, however pathaphysiological mechanisms stay unclear. To evaluate the state of small nerve fibers that should be affected first, we use thermal threshold testing, setting the thermal threshold for warm and cold stimuli in different locations. Patients with hypothyroidism show in most of the measured locations higher thermal threshold than that of the control group, however these results are not significant. Significant change of thermal sensation of cold stimulus is demonstrated in location thenar. Patients with hypothyroidism also have a higher degree of inaccuracy detection of thermal stimuli. A greater number of significant conclusions can not seem to reach for a small number of probands participating in our study or due to ongoing therapy and the resulting normal state...

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