National Repository of Grey Literature 7 records found  Search took 0.00 seconds. 
Expression of cytokines, particularly chemokines, after application of acyclic nucleoside phosphonates
Potměšil, Petr ; Zídek, Zdeněk (advisor) ; Otová, Berta (referee) ; Farghali, Hassan (referee)
Acyclic nucleoside phosphonates (ANPs) are novel class of virostatics, that inhibit replication of both DNA viruses and retroviruses. ANP approved for the treatment of viral diseases are: tenofovir (Viread®) for the therapy of AIDS, adefovir (Hepsera®) for the treatment of hepatitis B and cidofovir (Vistide®), that is used in HIV-1 positive patients suffering from retinitis caused by cytomegalovirus [23, 24]. Some ANPs, such as tenofovir, are endowed by immunomodulatory properties that can non specifically influence replication of viruses. Tenofovir has been shown previously to increase gene expression of nitric oxide, cytokines TNF- , IL-10 and chemokines RANTES, MIP-1 [6, 22, 30]. In present experiments we investigated possible immunobiological properties of newly synthesized derivatives of ANPs in vitro using mouse macrophages and lymphocytes (or human leukocytes, respectively). N6-substituted derivatives of adenine or 2,6-diaminopurine, that possess phosphonomethoxyethyl or phosphonomethoxypropyl moiety at the position N9 of the heterocyclic base were included in the study. Some of these compounds were found to activate production of nitric oxide, cytokines TNF- , IL-10 and chemokines RANTES, MIP- 1 [21]. Various hydroxylated derivatives of ANPs were also screened for their immunobiological potential....
Shakespeare and the Law
Židek, Zdeněk ; Wintr, Jan (advisor) ; Maršálek, Pavel (referee)
The topic of the thesis is the connection of the renowned bard and writer William Shakespeare with the Law. The thesis points out some of the most interesting legal remarks, which can be found during the course of the study of the Shakespeare's texts. The aim of the thesis is to broaden the knowledge of the depth of Shakespeare's plays, romances and sonnets and their legal connotation that never ceases to amaze both the general public, and the readers of legal education. The thesis is prefaced by the treatise regarding the connection of the law with the literature through the Law and Literature movement. The following chapter notes reasons why is it appropriate to study literary texts for the practice of legal professions, namely in the connection to the courts' decisions. Decisions of the US Supreme Court and the Czech Constitutional Court are mentioned in the thesis. In the following lines the author notes the issues one might face while translating the Shakespeare's remarks, especially those of legal connotation ; and mentions some of Shakespeare's law-related remarks. A notable portion of the thesis deals with three plays and their law-related contents. In the passage regarding the comedy Measure for Measure, Shakespeare's interest in a topic that is still actual nowadays is pointed out - the...
Expression of cytokines, particularly chemokines, after application of acyclic nucleoside phosphonates
Potměšil, Petr ; Zídek, Zdeněk (advisor) ; Otová, Berta (referee) ; Farghali, Hassan (referee)
Acyclic nucleoside phosphonates (ANPs) are novel class of virostatics, that inhibit replication of both DNA viruses and retroviruses. ANP approved for the treatment of viral diseases are: tenofovir (Viread®) for the therapy of AIDS, adefovir (Hepsera®) for the treatment of hepatitis B and cidofovir (Vistide®), that is used in HIV-1 positive patients suffering from retinitis caused by cytomegalovirus [23, 24]. Some ANPs, such as tenofovir, are endowed by immunomodulatory properties that can non specifically influence replication of viruses. Tenofovir has been shown previously to increase gene expression of nitric oxide, cytokines TNF- , IL-10 and chemokines RANTES, MIP-1 [6, 22, 30]. In present experiments we investigated possible immunobiological properties of newly synthesized derivatives of ANPs in vitro using mouse macrophages and lymphocytes (or human leukocytes, respectively). N6-substituted derivatives of adenine or 2,6-diaminopurine, that possess phosphonomethoxyethyl or phosphonomethoxypropyl moiety at the position N9 of the heterocyclic base were included in the study. Some of these compounds were found to activate production of nitric oxide, cytokines TNF- , IL-10 and chemokines RANTES, MIP- 1 [21]. Various hydroxylated derivatives of ANPs were also screened for their immunobiological potential....
Biological properties of the C-8 substituted analogues of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA)
Janeba, Zlatko ; Holý, Antonín ; Zídek, Zdeněk
The 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) derivatives substituted at the C-8 position of the purine moiety did not exhibited any pronounced antiviral or antimalarial activity, but both 8-hydroxy and 8-sulfanyl derivatives of PMEA possess significant immunostimulatory activities.
The role of innate immunity cells in coeliac disease: response of PBMC to gliadin digest
Tučková, Ludmila ; Jelínková, Lenka ; Cinová, Jana ; Zídek, Zdeněk ; Tlaskalová, Helena
The aim of the study was to asses the role of cells of innate immunity in the pathogenetic mechanisms of coeliac disease.

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2 Židek, Zdeněk
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