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RF coil for MR systém
Vojtíšek, Miloš ; Kořínek, Radim (referee) ; Gescheidtová, Eva (advisor)
The bachelor thesis is focused on radio frequency coils for magnetic resonance imaging systems. Magnetic resonance is used for imaging of many objects, especially human body in medicine, plants and many other different objects. For obtaining optimal results it is essential to use a special suitable coil for every single application. In the first part of this work, the short overview of principles of magnetic resonance imaging is described followed by a look at hardware used in MRI. The main aim of the work is design of several different types of RF coils used in MRI. Finally two suitable designs have been chosen for the purpose. Coils have been realized, tested in experiments. Results were analyzed, maps of generated magnetic field were calculated and homogeneity was determined.
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Baugruppe Now
Vojtíšek, Martin ; Landa, Filip (referee) ; Hora, Jan (advisor)
Me_zi is a project of apartment building that follows the baugruppe system. Part of the project inspects boundaries be tween personal and shared spaces and their form. The building is part of a house block in Znojmo. Study is based on 12 different requirements for living and forms a compact, multifunctional building. This study emphasizes private and community space for its occupants and their connection to neighborhood.
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Spatio-temporal distribution of atmospheric aerosol in urban and rural environment
Bendl, Jan ; Hovorka, Jan (advisor) ; Mikuška, Pavel (referee) ; Vojtíšek, Michal (referee)
Air quality in Europe remains a significant environmental concern, affecting the health and quality of life of its population. While stationary network ambient air quality monitoring allows for the observation of main trends, it is not fully representative of personal exposure of citizens due to high spatio-temporal variability of atmospheric aerosol. Therefore, highly time-and- space resolved measurements with state-of-the-art instruments and methods are needed to observe the aerosol variability, dynamics, identify hot-spots, and pollution sources, which are necessary for successful targeted mitigation measures. This thesis addresses this gap focusing on the characterization of spatio-temporal distribution of atmospheric aerosol in inhabited environments. Novel mobile measurement systems were developed and employed to investigate diverse environments, including rural, urban and suburban area. Aerosol source-apportionment were conducted, and the toxicological effects associated with these environments were also investigated. A novel mobile measurement system was developed for personal exposure measurements and pollution mapping in urban and rural environments. The system was used to measure air quality in the Munich subway, revealing high aerosol dynamics with significantly higher concentrations of...
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Structuralism for the 21st Century
Vojtíšek, Martin ; Štojdl, Václav (referee) ; Rozwalka, Szymon (advisor)
Nomos is partly a theoretical project that explores differences between Dutch Structuralism and Japanese Metabolism and tries to find a contemporary architectural system, that is intended as a contemporary interpretation of these movements. The project emphasizes an underutilization of the changeability of our environment and tries to incorporate it into the design of the system so that the user can customize it. It explores ways to combine the benefits of organic growth and modular design through the simulation of a reaction-diffusion. The application of the system shows a possible solution in a specific context with the design of a fragment.
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Toxic responses in human lung epithelial cells (BEAS-2B) exposed to particulate matter exhaust emissions from gasoline and biogasoline
Závodná, Táňa ; Líbalová, Helena ; Vrbová, Kristýna ; Sikorová, Jitka ; Vojtíšek-Lom, M. ; Beránek, V. ; Pechout, M. ; Kléma, J. ; Cigánek, M. ; Machala, M. ; Neča, J. ; Rössner ml., Pavel ; Topinka, Jan
Motor vehicle emissions substantially contribute to air pollution worldwide and cause serious health problems. While the deleterious effects of diesel exhaust particulate matter (PM) have been widely studied, much less attention is paid to toxicity of PM emitted by gasoline engines although they also produce considerable amount of PM. The primary objective of this research was to assess toxic potencies of exhaust PM released by conventional gasoline engine fueled with neat gasoline (EU) or gasoline-ethanol blend (15% ethanol, v/v, E15). Despite a similar particle mass (mu g PM/kg fuel) produced by both fuels, PM emitted by E15 contained higher amount of harmful polycyclic aromatic hydrocarbons (PAH) as suggested by chemical analysis. To examine the toxicity of organic PM constituents, human lung BEAS-2B cells were exposed for 4h and 24h to a subtoxic dose of E0 and E15 PM organic extracts. We used genome scale transcriptomic analysis to characterize the toxic response and to identify modulated biological process and pathways. Whereas 4h exposure to both PM extracts resulted in modulation of similar genes and pathways related to lipid and steroid metabolism, activation of PPAR alpha, oxidative stress and immune response, 24h exposure was more specific for each extract, although both induced expression of PAH-metabolic enzymes, modulated metabolism of lipids or activated PPAR alpha, E15 additionally deregulated variety of other pathways. Overall, the PM mass produced by both fuels was similar, however, higher PAH content in E15 PM organic extract may have contributed to more extensive toxic response particularly after 24h exposure in BEAS-2B cells.
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The entry of lead into the brain after experimental administration of lead acetate
Patková, Jana ; Vojtíšek, Maxmilián (advisor) ; Žurmanová, Jitka (referee)
Lead is a ubiquitous environmental toxin that induces a broad range of fysiological, biochemical and behavioral dysfunctions in man and in experimental animals. The present study is focused on the effect of lead on the central nervous system, which is considered to be most deleterious, especially alterations of cognitive and behavioral functions. New concepts in the neurotoxicology of lead include advances in understanding mechanisms of lead-induced damage to the nervous system, like induction of oxidative stress. In the experimental part the entry of lead into the brain of mature mice after long-term exposure to lead acetate (PbAc) and the influence of lead on cognitive function and motoric skills of exposed animals were observed. Cognitive function was tested in Morris water maze, motoric tests were performed on rotating cylinder and horizontal wire. Healthy and neurodefective Lurcher mutant mice were used. Further the influence of lead on the development of oxidative stress in the brain by fluorescent spectroscopy was studied. Lipofuscin-like pigments were used as indicators of oxidative stress. The prominent accumulation of lead in the brain of exposed animals as compared to controls was observed after the long-term exposure of mice to PbAc. No changes in motoric or cognitive functions in healthy or...
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Study of aerosol properties with high time resolution
Kubelová, Lucie ; Ždímal, Vladimír (advisor) ; Hovorka, Jan (referee) ; Vojtíšek, Michal (referee)
This thesis focuses on physical and chemical characteristics of atmospheric aerosol measured with high time resolution. Size distribution, chemical composition, and volatility of submicron particles were studied in relation to meteorological conditions and other factors. To reach higher variability in ambient conditions, we considered atmospheric aerosol during two seasons of the year (summer and winter) and at two different locations (suburban site Prague Suchdol and rural site Košetice). Measurement during two different seasons enabled us to better distinguish the influence of seasonal sources such as domestic heating in winter and increased biogenic emissions in summer. Also, seasonal differences in meteorological conditions mainly in case of temperature, humidity, and solar radiation were shown to play a role in aerosol characteristics. A comparison of aerosol properties at two different measurement sites, namely a rural and suburban, enabled us to better characterize the role of background aerosol and the influence of the city. Furthermore, a transformation of aerosol particles entering indoors from outdoors was also studied within this thesis. The influence of indoor/outdoor temperature and humidity gradient as well as presence of new particle formation events on the indoor/outdoor ratio was...
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