National Repository of Grey Literature 49 records found  1 - 10nextend  jump to record: Search took 0.01 seconds. 
Treatment options for untreatable amoeba Naegleria fowleri
Veselý, Martin ; Mach, Jan (advisor) ; Arbon, Dominik (referee)
Naegleria fowleri is a free-living protist which can penetrate the body of a previously healthy person and cause meningoencephalitis. The rapid course, disproportionately strong immune response and the lack of effective drugs are the reasons why this disease almost always ends fatally. Due to the relative rarity of this disease, it is not lucrative for pharmaceutical companies to develop a completely new drug. The only way to search for effective drugs is to test those that have already been approved for another purpose. However, clinical tests are not possible due to the low morbidity and rapid course of the disease, and research in this area is thus limited to animal models of the disease and evaluation of the effect of drugs against the pathogen in vitro. Currently used medication includes drugs that are highly toxic or poorly penetrate the site of inflammation. In the future, more effective chemotherapy against N. fowleri and more gentle towards patient could be used. This work summarizes knowledge about pathogenic amoeba, currently used drugs and presents new experimentally tested therapeutics.
BUILDING A PLACE ATTACHMENT AMONG HOUSING ESTATE RESIDENTS: A CASE STUDY OF THE ĎÁBLICE AND SPOŘILOV HOUSING ESTATES
Bečvář, Daniel ; Špačková, Petra (advisor) ; Veselý, Martin (referee)
The thesis deals with the topic of place attachment, i.e. the emotional bond of a person to a place, in this case to the place of residence, with a focus on residents of socialist housing estates. The first part of the thesis is devoted to the theoretical background. It discusses, on the one hand, the available literature on the development of place attachment, the ways of measuring it or the psychological nature of this attachment itself. Also, the phenomenon of modernist housing estates and their contemporary image is described in this part. In the second, empirical part, the aim is to find out how place attachment is formed among the residents of the housing estates, what further influences this relationship, and how this process of evolving differs in the two estates. The research is qualitative in nature and the main method of data collection is semi-structured interviews. The case study was carried out in two housing estates in Prague, which differ both in size and in how well they are known by the general public - the Ďáblice housing estate and the Spořilov housing estate. In this work, three mechanisms leading to the development of place attachment were identified - growing local familiarity, intensive time spent on the estate, and civic engagement. In addition to the mechanisms, the...
Project Management Assessment and Proposal of modification
Slámová, Tereza ; Veselý, Martin (referee) ; Širáňová, Lenka (advisor)
The diploma thesis deals with the assessment of the current project management setting in the JONCERS company and the proposal for its efficiency and security improvement. The thesis includes detailed look at the general project management setting, which company use and detailed analysis of one chosen project. Analysis of the current state of the project is made by using own created analysis of the project and project team setting and by using the risk analysis. Subsequently, the thesis contains solution proposals, which goal is improvement of project management weaknesses and by it achieve higher security and efficiency.
Secondary metabolites in fungal pathogenesis
Veselý, Martin ; Čmoková, Adéla (advisor) ; Machová, Lenka (referee)
The ability of fungal pathogens to induce infection and later survive in its host is dependent on virulence factors. Often these factors are based on primary metabolites (hydrophobins, proteases, phospholipases, catalases etc.). Nonetheless many pathogen produced secondary metabolites are also involved in the infection process. Their true role during infection used to be rather undervalued. First part of this bachelor degree thesis aims to describe host-pathogen relation and afterwards introduce reader with some basic, commonly accepted virulence factors of fungi. In the second part of this thesis known roles of secondary metabolites are described in each stages of progressing infection. In the first stage a pathogen needs to create a suitable habitat on host tissues to ensure growth. This is in part done by antimicrobial substances (...). In later stages pathogen prevents phagocytosis of its spores by host (melanins). Successful infection is often accompanied with host tissue damage that is induced by production of cytotoxic substances (xanthomegnin, riboflavin) and immunoregulation of host immune system (gliotoxin, pseurotin). Last but not least there are virulence factors that ensure prolonged survival in host (siderophores). Fungal pathogens of poikiloterm animals are mostly not primary...
Information System Efectiveness Assessment and Proposal for ICT Modification
Brodňanský, Erik ; Veselý, Martin (referee) ; Neuwirth, Bernard (advisor)
The diploma thesis focuses on the assessment of the information system, which is used to record the hours worked, in a specific company. In addition to the assessment of the system itself, it also deals with the proposal for its change, the implementation procedure, together with the risk management and time analysis. The content of the work is, in addition to the above, the analysis of the company in terms of external and internal environment, a description of the information systems used and their audit.
Revitalisation of post-mining sites
Veselý, Martin ; Chuman, Tomáš (advisor) ; Matějček, Tomáš (referee)
This work introduces and compares some basic facts about recultivation and alternative methods of restoration, such is revitalization and natural succession. Recultivation is the way of quick revegetation, but it's expensive and in many cases contraproductive considering biodiversity of recultivated sites. Whereas, approaches based on principles of ecological restoration have many positives. They can create much valuable landscape structures and ecosystems than recultivation, and they enhance biodiversity and conservation of rare species.
Vegetation succession and soil development on heaps from brown coal mining
Veselý, Martin ; Chuman, Tomáš (advisor) ; Šefrna, Luděk (referee)
Plant diversity and selected soil parameters from 36 sites placed on brown coal mining spoil heaps were analyzed and compared. Spontaneously revegetated or technically reclaimed spoil heaps of different age were situated in brown coal mining district of eastern Most basin in north western part of the Czech republic. Samples were sorted in groups according to vegetation growth and type. Plant diversity increases during succession development and is higher on non-reclaimed sites than reclaimed sites, where diversity decreases with time. Soil bulk density decreases during succession on all sites. Soil pH is decreasing too and this process is faster on spontaneously revegetated sites. Old successional forest type sites have very acid soils probably due to properties of original mineral matrix. Thickness of organic horizon and A horizon is increasing during succession and they appear in mid-aged sites first. Content of soil organic carbon is increasing continuously. Non-reclaimed sites reach higher contents, mainly because of higher content of fossil organic matter in spoil mineral matrix. Keywords: vegetation succession, soil development, reclamation, brown coal mining heaps
Retardation, collaboration and activism of army elite in the Protectorate Bohemia and Moravia
Veselý, Martin ; Gebhart, Jan (advisor) ; Borák, Mečislav (referee) ; Němeček, Jan (referee)
5 Abstract: Dissertation work is concerned with a political activism phenomenon, retardation and programme collaboration of army elite in Bohemia and Moravia Protectorate study. The aim of the work is to explore and chart the public and political life in Bohemia and Moravia Protectorate with a special attention to high Czech commissioned officer activity not only to summarize the acquired information but also to put them into the context with a development of Protectorate autonomous and occupation politics. The Thesis is not only focuses on the activity on the main organisations and their leading personalities but devotes its attention to opinions and points of view of centers of protectorate autonomous and occupation administration towards them, which had an influence on the organisation activity and their leaders. It situates them into the protectorate politics on the background of the events. The Thesis theme concentrates basically on the activity of the main Protektorate organisations and of the former soldiers such as Czech Union of Warriors and Central Union Former Soldiers in Bohemia and Moravia and their leaders - the general Otto Bláha, Robert Rychtrmoc and Bohuslav Kálala. In addition to that it also focuses on the activity of political and statutory organisations called National Conviviality,...
The Development of a Housing Sustainability Assessment Tool
Adamec, Jakub ; Janoušková, Svatava (advisor) ; Veselý, Martin (referee) ; Moldan, Bedřich (referee)
Sustainable development is a principal concept for housing, urban infrastructure, energetics, transportation, or business. Fragmentation of concept definition is a result of abusive term overuse by the entire society. In 2015 UNECE established a clear sustainable housing definition through The Geneva UN Charter on Sustainable Housing and its 34 Rationales. The UN encourages its member states to measure progress in sustainable development through existing or newly developed indicators. Existing commercial housing evaluation tools are insufficient for the Geneva UN Charter concept. Initially, the tools measured the so-called greenness of buildings overlooking anthropocentric and social qualities of housing underlined in the UN Geneva Charter. Commercial certification tools heavily reliant on profits often utilize incorrect concepts of sustainability. That results in false sustainability. This work aspires to introduce a transparent housing sustainability assessment tool for the Czech Republic. Firstly, were identified unique phenomena outlining the concept of housing sustainability. To identified phenomena were consequently nominated and assigned appropriate indicators. While in a different situation is housing interpreted as a human environment, building, home, investment, or fundamental human...
Nonparametric tests of independence between animal movement trajectories
Veselý, Martin ; Dvořák, Jiří (advisor) ; Omelka, Marek (referee)
In this thesis, we assume observing a pair of trajectories of two objects which could interact with one another and we want to propose a way to test their independence. We formulate basic point process definitions and discuss ways to describe trajectory data. We formulate the theory behind Monte Carlo tests and global envelope testing. In Chapter 2, we propose a parametric model to represent trajectories and derive Maximum Likelihood estimates of its model. We conclude the chapter by exploring the performance of these estimates. In Chapter 3, we propose test statistics used to test for independence using a nonparametric Monte Carlo test based on a random shift approach. We perform a simulation study to assess the performance of these statistics under various conditions and discuss the selection of fine-tuning parameters. Finally, in Chapter 4, we study real data provided by the Voyageurs Wolf Project and apply the proposed tests on real wolf trajectories. 1

National Repository of Grey Literature : 49 records found   1 - 10nextend  jump to record:
See also: similar author names
35 VESELÝ, Martin
14 VESELÝ, Milan
8 Vesely, Michal
3 Veselý, M.
9 Veselý, Marek
2 Veselý, Matyáš
4 Veselý, Matěj
1 Veselý, Michael
8 Veselý, Michal
2 Veselý, Mikuláš
14 Veselý, Milan
3 Veselý, Miloslav
2 Veselý, Miloš
4 Veselý, Miroslav
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