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Changes of bone mass density in selected endocrine diseases
 Vašátko, Tomáš ; Čáp, Jan (advisor) ; Zamrazil, Václav (referee) ; Hána, Václav (referee)
Osteoporosis is a serious social and medical problem. About 6% people suffer from osteoporosis in European countries. As for aetiology it is a multi-factorial disease. Endocrinopaties play an important role in it's development. We focused on three specific endocrinopaties with relation to bone metabolism in our study. Goal of the study: 1/ To evaluate the influence of long term thyroid hormone therapy (substitution and suppressive dose) on bone mass and bone metabolism. 2/ To evaluate the possibility of prediction of bone mass increase after the operation in patients with mild primary hyperparathyroidism. 3/ To evaluate changes of bone mass, bone metabolism and body composition in patients with growth hormone deficiency treated with growth hormone substitution. Patients and methods: 1/ a) First - cross sectional part of the study - 76 patients on suppressive dose of L-thyroxine therapy, 34 patients on substitution therapy. We examined bone markers and bone mass in each group. We evaluated how each of the two doses of therapy influences the bone metabolism and we compared the groups with each other. b) In second - prospective part of the study - we observed the changes of bone mass in the course of the time (5 years) in each group. 2/ Retrospective cross-sectional study - 54 patients with primary...
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