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Evaluation of antimicrobial effectiveness of octenidine derivatives
Šefránková, Laura ; Kovařík, Miroslav (advisor) ; Vávrová, Pavlína (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Kralove Department of Biological and Medical Sciences Author: Laura Šefránková Supervisor: PharmDr. Miroslav Kovařík, Ph.D. Consultant: Mgr. Michaela Hympánová, Ph.D. Title: Evaluation of antimicrobial effectiveness of octenidine derivatives Diploma thesis Study program: Pharmacy Introduction: Octenidine dihydrochloride belongs to the group of so-called "gemini" surfactants, or bis-quaternary equivalents of quaternary ammonium salts (QAS). QAS are generally widely used disinfectants exhibiting relatively low toxicity and high efficacy. Bis- quaternary QAS are characterised by even better surface activity and biodegradability. Octenidine dihydrochloride is considered as a very promising antimicrobial agent for its high antimicrobial activity even against multi-drug resistant bacteria. However, its limited solubility in aqueous solvents complicates its application due to the need of organic solvents in product composition, which afterwards reduce wounds or mucous membranes tolerability. Aim: The aim of this work was to test the antimicrobial efficacy of 11 new derivatives of octenidine dihydrochloride, which were prepared with emphasis to increase efficiency and improve solubility in aqueous solutions. Methods: The microdilution broth method...
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Antisemitism in daily Venkov, České slovo and Večerní české slovo in the season 1939-1941
Vávrová, Pavlína ; Bednařík, Petr (advisor) ; Köpplová, Barbara (referee)
Thesis is focused on analysing the content of anti-Semitic materials and its aim is to find out how the amount of such materials was changing in three chosen newspapers which had been legally published in Protectorate Bohemia and Moravia in the period March 1939 - September 1941. Those materials have been divided into categories according to the character of their content. In the thesis, there is mentioned how the amount of anti-Semitic materials changed inside each category. In the conclusion, the single results of each daily are compared here.
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Jan Werich's travelogue texts essays and critical reflexion in media
Vávrová, Pavlína ; Čeňková, Jana (advisor) ; Osvaldová, Barbora (referee)
Thesis describes Jan Werich's creation of opinion he wrote during the 50's and 60's of 20th century and that was published as a book or in press. Author concentrates on genre analysis and composition of Werich's texts. First, describes character of the texts and tries to classify them. Then, detailed description of those texts follows. The critical reflexion in media is also included. Thesis presents content of each critique and it compares all of them. The description of Werich's creation and critiques are supported by quotes. In the end of the thesis, all the critiques are compared quantitatively and qualitatively.
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