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Ovarian carcinomas - the influence of the Rho kinase family on cell migration
Barešová, Veronika ; Urbánková Rathouská, Jana (advisor) ; Fikrová, Petra (referee)
Author: Veronika Barešová Title: Ovarian carcinomas - the influence of Rho family kinases on cell migration Diploma thesis Charles University, Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Ovarian carcinomas are the deadliest group of gynecological malignancies. This is due to a high rate of metastasis and acquired drug resistance. Metastasis is characterized by a phenotypic change of cells from epithelial to mesenchymal, resulting in the loss of cell-cell and cell-extracellular matrix contacts and subsequent cell movement. This process is called epithelial-mesenchymal transition and has been shown to also play a role in cell resistance to cisplatin. The movement of individual cells is mediated by the Rho GTPase family and can be divided into mesenchymal and amoeboid types. The amoeboid type is characterized by the Rho/ROCK signaling pathway, while mesenchymal movement is mediated by the Rac/Cdc42 pathways. In my thesis, we investigated the differences in expression of selected proteins in both signaling pathways in ovarian carcinoma cells. Initially, we focused on comparing the A2780 and A2780cis cell lines, which are resistant to cisplatin. We monitored markers of amoeboid movement, RhoA and phosphorylated myosin, and markers of mesenchymal movement, Wave-2,...
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Experience with Preparatory Classes in Socialli Excludet Localities in Most
Urbánková Mikulová, Jitka ; Lorenzová, Jitka (advisor) ; Valášková Vincejová, Eva (referee)
The bachelor thesis deals with the topic of socially disadvantage environment and the mening of preparatory classes for children from the socially excluded areas. The preparatory classes are a measure which could help find a solution to this complicated issue in the education process in the socially excluded areas of Most. The aim of the thesis is to determine the opinions and the evalution from the teachers to the preparatory classes in the socially excluded areas. The charakter of the thesis is the theoretically-empirical. The theoretical part is aimed at definic the terms of the given issue. The empirical part is focused on the qualitive research which is implemented in form half-structured interviews with the teachers of the preparatory classes and also with the teachers from primary schools who had the expirience with teaching children from the preparatory classes in the socially excluded areas Powered by TCPDF (www.tcpdf.org)
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Measuring Financial Instability: A Survey
Urbánková, Jana ; Baxa, Jaromír (advisor) ; Kolouchová, Petra (referee)
This thesis aims to analyze how various theoretical definitions describe and assess financial stability, and how these definitions are actually being reflected in the measurement methods used to evaluate financial stability. The first section lists different theoretical approaches to defining financial stability, extrapolates main components that characterize these approaches, and compares these approaches based on the components. The thesis continues with a description and critical assessment of financial stability measurement methods. Special attention is paid to financial conditions and financial stress indexes, which are compared based on actual data for the United States. The last section explores to what extent these components are compatible with financial stability measurement methods listed in the previous section. This thesis also points out that most methods measure financial instability, as opposed to financial stability, perhaps because instability is less abstract and, thus, more convenient for an effective measurement. The thesis concludes that recent quantitative assessments of financial stability are real time assessments rather than strong predictive indicators of financial (in)stability and, thus, they do not offer policymakers enough time and information for timely policy...
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