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Chronic vulvovaginal discomfort and quality of vaginal environment
Kestřánek, Jan ; Špaček, Jiří (advisor) ; Unzeitig, Vít (referee) ; Hořejší, Jan (referee)
"Chronic vulvovaginal discomfort and quality of vaginal enviroment" Vulvovaginal discomfort (VVD) is not a life-threatening disease, however, its impact on quality of life is enormous. The causes of the origins of the chronic form are not provably clarified. OBJECTIVES OF THE THESIS: The first aim of this thesis has been to make an attempt to reveal the etiology of chronic vulvovaginal discomfort (CVD), to characterize a group of patients with CVD and refer it to the quality of vaginal environment. The second aim has been an evaluation of a questionnaire, which had been focused on probable causal factors of CVD. The third part is experimental, focused on the issue of quorum sensing molecule (QSM) and manosa-binding lectin (MBL) polymofrisms. METHODS: The data for all three parts of the study were gained at the outpatient's department for CVD by examinig and following CVD patients. A questionnaire was used when investigating the probable CVD factors. RESULTS: The study has proved that we come across the idiopatic form of CVD in most cases. According to the results, the issue concerns mainly women at productive age, in most cases healthy, without an evident trigger moment. The study has also shown that the most noticeable finding in CVD patients is an absence of lactobacillus proved when performing a...
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Chronic vulvovaginal discomfort and quality of vaginal environment
Kestřánek, Jan ; Špaček, Jiří (advisor) ; Unzeitig, Vít (referee) ; Hořejší, Jan (referee)
"Chronic vulvovaginal discomfort and quality of vaginal enviroment" Vulvovaginal discomfort (VVD) is not a life-threatening disease, however, its impact on quality of life is enormous. The causes of the origins of the chronic form are not provably clarified. OBJECTIVES OF THE THESIS: The first aim of this thesis has been to make an attempt to reveal the etiology of chronic vulvovaginal discomfort (CVD), to characterize a group of patients with CVD and refer it to the quality of vaginal environment. The second aim has been an evaluation of a questionnaire, which had been focused on probable causal factors of CVD. The third part is experimental, focused on the issue of quorum sensing molecule (QSM) and manosa-binding lectin (MBL) polymofrisms. METHODS: The data for all three parts of the study were gained at the outpatient's department for CVD by examinig and following CVD patients. A questionnaire was used when investigating the probable CVD factors. RESULTS: The study has proved that we come across the idiopatic form of CVD in most cases. According to the results, the issue concerns mainly women at productive age, in most cases healthy, without an evident trigger moment. The study has also shown that the most noticeable finding in CVD patients is an absence of lactobacillus proved when performing a...
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