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Nanoparticles based on complexes of hydrophilic block polyelectrolytes and new gemini ionic surfactants
Šomšáková, Katarína ; Uchman, Mariusz Marcin (advisor) ; Trhlíková, Olga (referee)
This bachelor thesis deals with preparation and study of the aqueous solutions of block polyelectrolyte poly(2-vinylpyridine)-b-poly(ethylen oxide), P2VP-PEO with gemini surfactants 6,6'-(ethan-1,2-diylbis(oxy)) bis(3-dodecylbenzenesulfonate acid), 6,6'- (buthan-1,4-diylbis(oxy)) bis(3- dodecylbenzenesulfonate acid) and 6,6'-(hexane-1,6- diylbis(oxy)) bis(3- dodecylbenzenesulfonate acid) complexes and with P2VP-PEO and sodium dodecylsulfate, SDS, complexes, and compares their physico-chemical properties. Formed particles were characterized by static and dynamic light scattering, zeta potential, isothermal titration calorimetry and transmission cryo-electron microscopy. Even small amount of surfactant leads to coassembly of P2VP-PEO with surfactants, formed by PEO shell and P2VP/surfactant core. The nanoparticles of block polyelectrolyte and gemini surfactants in 0.1M HCl are stable and their size depends on the spacer lenght and the surfactant/polymer ratio.
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Study of molecular weight and configurational stability of substituted polyacetylenes
Trhlíková, Olga ; Sedláček, Jan (advisor) ; Netopilík, Miloš (referee) ; Žigon, Majda (referee)
3 ABSTRACT Complexes [Rh(cycloolefin)(acac)] (cycloolefin = norborna-2,5-diene, cycloocta- 1,5-diene and cyclooctatetraene) were investigated as catalysts of polymerization of monosubstituted acetylenes into stereoregular cis-transoid polyacetylenes. All complexes were highly active in arylacetylenes polymerizations in both coordinating and non-coordinating solvents. Selection of solvent and cycloolefin ligand of the catalyst allowed the control over polymer MW. The onset of initiation in the [Rh(cycloolefin)(acac)]/monomer systems proceeded as the proton transfer from the monomer molecule to the acac ligand under the release of acetylacetone and coordination of -C≡CR ligand to Rh(cycloolefin) moiety. Cis-transoid poly(phenylacetylene) and poly[(2,4-difluorophenyl)acetylene]s with required initial MW were prepared with these catalysts and submitted to the long-term ageing in which the polymers were exposed to the atmosphere and diffuse daylight either dissolved in tetrahydrofuran or in the solid state. Tightly connected processes of cis-to-trans isomerization of the polymer main-chains double bonds and oxidative degradation were found to proceed during polymers ageing in the solution. Besides, the formation of corresponding cyclotrimers accompanied the polymers ageing. However, the cyclotrimers amount was...
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Study of molecular weight and configurational stability of substituted polyacetylenes
Trhlíková, Olga
Complexes [Rh(cycloolefin)(acac)] (cycloolefin = norborna-2,5-diene, cycloocta- 1,5-diene and cyclooctatetraene) were investigated as catalysts of polymerization of monosubstituted acetylenes into stereoregular cis-transoid polyacetylenes. All complexes were highly active in arylacetylenes polymerizations in both coordinating and non-coordinating solvents. Selection of solvent and cycloolefin ligand of the catalyst allowed the control over polymer MW. The onset of initiation in the [Rh(cycloolefin)(acac)]/monomer systems proceeded as the proton transfer from the monomer molecule to the acac ligand under the release of acetylacetone and coordination of -C≡CR ligand to Rh(cycloolefin) moiety. Cis-transoid poly(phenylacetylene) and poly[(2,4-difluorophenyl)acetylene]s with required initial MW were prepared with these catalysts and submitted to the long-term ageing in which the polymers were exposed to the atmosphere and diffuse daylight either dissolved in tetrahydrofuran or in the solid state. Tightly connected processes of cis-to-trans isomerization of the polymer main-chains double bonds and oxidative degradation were found to proceed during polymers ageing in the solution. Besides, the formation of corresponding cyclotrimers accompanied the polymers ageing. However, the cyclotrimers amount was too...
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Multicompartment nanoparticles based on ABC triblock terpolymers as potential drug delivery vehicels
Hlavatovičová, Eva ; Uchman, Mariusz Marcin (advisor) ; Trhlíková, Olga (referee)
This thesis deals with the self-assembly behavior of newly synthetized well-defined amphiphilic poly(acrylic acid)-b-poly(4-hydroxystyrene)-b-poly(styrene-carborane) triblock terpolymer in aqueous solution. A reproducible method was developed for the preparation of diverse multicompartment boron-containing nanostructures (spherical micelles, wormlike micelles) depending on the initial solvent composition and solvophobic-solvophilic interactions. Self-assembled nanostructures were characterized by various techniques (static and dynamic light scattering, cryogenic transmission-electron microscopy and fluorescence spectroscopy). The solubilization of two model drugs (2-methylnaphtalene and 7- methoxycoumarine-carborane fluorophores) in polymer nanoparticles was studied by fluorescence spectroscopy to investigate its potential in drugs solubilization and delivery.
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Nanoparticles based on complexes of hydrophilic block polyelectrolytes and new gemini ionic surfactants
Šomšáková, Katarína ; Uchman, Mariusz Marcin (advisor) ; Trhlíková, Olga (referee)
This bachelor thesis deals with preparation and study of the aqueous solutions of block polyelectrolyte poly(2-vinylpyridine)-b-poly(ethylen oxide), P2VP-PEO with gemini surfactants 6,6'-(ethan-1,2-diylbis(oxy)) bis(3-dodecylbenzenesulfonate acid), 6,6'- (buthan-1,4-diylbis(oxy)) bis(3- dodecylbenzenesulfonate acid) and 6,6'-(hexane-1,6- diylbis(oxy)) bis(3- dodecylbenzenesulfonate acid) complexes and with P2VP-PEO and sodium dodecylsulfate, SDS, complexes, and compares their physico-chemical properties. Formed particles were characterized by static and dynamic light scattering, zeta potential, isothermal titration calorimetry and transmission cryo-electron microscopy. Even small amount of surfactant leads to coassembly of P2VP-PEO with surfactants, formed by PEO shell and P2VP/surfactant core. The nanoparticles of block polyelectrolyte and gemini surfactants in 0.1M HCl are stable and their size depends on the spacer lenght and the surfactant/polymer ratio.
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Study of molecular weight and configurational stability of substituted polyacetylenes
Trhlíková, Olga ; Sedláček, Jan (advisor) ; Netopilík, Miloš (referee) ; Žigon, Majda (referee)
3 ABSTRACT Complexes [Rh(cycloolefin)(acac)] (cycloolefin = norborna-2,5-diene, cycloocta- 1,5-diene and cyclooctatetraene) were investigated as catalysts of polymerization of monosubstituted acetylenes into stereoregular cis-transoid polyacetylenes. All complexes were highly active in arylacetylenes polymerizations in both coordinating and non-coordinating solvents. Selection of solvent and cycloolefin ligand of the catalyst allowed the control over polymer MW. The onset of initiation in the [Rh(cycloolefin)(acac)]/monomer systems proceeded as the proton transfer from the monomer molecule to the acac ligand under the release of acetylacetone and coordination of -C≡CR ligand to Rh(cycloolefin) moiety. Cis-transoid poly(phenylacetylene) and poly[(2,4-difluorophenyl)acetylene]s with required initial MW were prepared with these catalysts and submitted to the long-term ageing in which the polymers were exposed to the atmosphere and diffuse daylight either dissolved in tetrahydrofuran or in the solid state. Tightly connected processes of cis-to-trans isomerization of the polymer main-chains double bonds and oxidative degradation were found to proceed during polymers ageing in the solution. Besides, the formation of corresponding cyclotrimers accompanied the polymers ageing. However, the cyclotrimers amount was...
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Study of molecular weight and configurational stability of substituted polyacetylenes
Trhlíková, Olga
Complexes [Rh(cycloolefin)(acac)] (cycloolefin = norborna-2,5-diene, cycloocta- 1,5-diene and cyclooctatetraene) were investigated as catalysts of polymerization of monosubstituted acetylenes into stereoregular cis-transoid polyacetylenes. All complexes were highly active in arylacetylenes polymerizations in both coordinating and non-coordinating solvents. Selection of solvent and cycloolefin ligand of the catalyst allowed the control over polymer MW. The onset of initiation in the [Rh(cycloolefin)(acac)]/monomer systems proceeded as the proton transfer from the monomer molecule to the acac ligand under the release of acetylacetone and coordination of -C≡CR ligand to Rh(cycloolefin) moiety. Cis-transoid poly(phenylacetylene) and poly[(2,4-difluorophenyl)acetylene]s with required initial MW were prepared with these catalysts and submitted to the long-term ageing in which the polymers were exposed to the atmosphere and diffuse daylight either dissolved in tetrahydrofuran or in the solid state. Tightly connected processes of cis-to-trans isomerization of the polymer main-chains double bonds and oxidative degradation were found to proceed during polymers ageing in the solution. Besides, the formation of corresponding cyclotrimers accompanied the polymers ageing. However, the cyclotrimers amount was too...
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