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Vývoj chemických regulátorů drah mikroRNA a RNAi
Bruštíková, Kateřina ; Svoboda, Petr (advisor) ; Bařinka, Cyril (referee) ; Pospíšek, Martin (referee)
MicroRNAs are noncoding RNAs inducing sequence-specific posttranscriptional inhibition of gene expression and represent the major class of small endogenous RNAs in mammalian cells. Over 2,500 of human microRNAs potentially regulating more than 60% of human protein-coding genes have been identified. MicroRNAs participate in the majority of cellular processes, and their expression changes in various diseases, including cancer. Currently, there is no efficient small chemical compound available for the modulation of microRNA pathway activity. At the same time, small chemical compounds represent excellent tools for research of processes involving RNA silencing pathways, for biotechnological applications, and would have a considerable therapeutic potential. The presented work represents a part of a broader project, whose ultimate goal is: (i) to find a set of small molecules allowing for stimulation or inhibition of RNA silencing and (ii) to identify crosstalks between RNA silencing and other cellular pathways. This thesis summarizes results from the first two phases of the project, the development of high-throughput screening assays and the high- throughput screening (HTS) of available libraries of small compounds. To monitor the microRNA pathway activity, we developed and optimized one biochemical...
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Service of documents in administrative proceedings
Drábková, Tereza ; Svoboda, Petr (advisor) ; Handrlica, Jakub (referee)
V ANGLICKÉM JAZYCE The thesis focuses on service of documents in administrative proceedings. At the beginning of the thesis, the used terminology and constitutional framework are defined. The main part deals with the two main forms of delivery, an electronic and a documentary form. Regarding the excessive use of electronic communication in today's society, the electronic form is described in detail. Afterwards, the thesis deals with the issue of the service of documents to foreign countries and defects that may occur during the delivery. Many uncertainties and questions have arisen putting an information system of data boxes and using of data boxes for communication between entities and administrative bodies into operation. The author therefore dedicated a considerable attention to this topic. Attention is also paid to the institute of electronic signature. This institute was adopted in the Czech legislation in accordance with European legislation. Elaborating this thesis, the author used primary legal sources, literature both domestic and foreign origin, and public information sources.
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Problematic aspects of public tenders from the perspective of a municipality
Hájková, Petra ; Svoboda, Petr (advisor) ; Millerová, Ivana (referee)
The problematic aspects of awarding of public procurement from the perspective of the municipality. The aim of this thesis is a presentation of certain problems associated with awarding of public procurement by public authority - the municipality. This thesis is divided into three parts. The first part provides a general introduction to the topic. This part defines the basic terms and principles associated with public procurement, attention is also focused on a definition of local government units. At the beginning of the second part a legal framework of public procurement and a brief view of the future legislativ is presented. The most important section of this part describes bodies of the municipality and their competences associated with awarding of public procurement. Thereafter it deals with mistakes and shortcomings which may arise during the tender process from the part of municipalities. In this part specific situations coming from the practical experience of municipalities are described and analysed, including a list of potential impacts on municipalities. Attention is also paid to current jurisdiction and decision making practices of the Office for Protection of Competition. The final part of this thesis summarizes the conclusions drawn in the previous chapters.
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Position and activities of intelligence services in the Czech Republic (legal aspects)
Šišlák, Stanislav ; Handrlica, Jakub (advisor) ; Svoboda, Petr (referee)
Status and activities of the intelligence services in the Czech Republic (legal aspects) My master's degree thesis attempts to analyse the status and activities of the intelligence services in the Czech Republic. Nowadays the importance of the intelligence services is steadily growing worldwide because of bigger threat of terrorists' attacks and worsening security situation in certain regions in the world. Czech intelligence services must adapt to this situation and that's why I started to investigate particular Czech legislation. I started to examine whether the Czech intelligence services are given necessary powers to fulfil their lawful duties, who governs and coordinates their activities, who controls them etc. All these questions are described and answered in the thesis. The thesis is composed of five chapters, each of them deals with different aspects of the status and activities of the intelligence services. Chapter one is more or less general, subsequent chapters are rather focused on Czech intelligence services. The first chapter is introductory. There are stated a few definitions of an intelligence service. In this chapter I also mentioned possible divisions of intelligence services and basic requirements of national legislation recommended by relevant international organisations and some other...
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Position and activities of the Czech Bar Chamber
Beranová, Tereza ; Svoboda, Petr (advisor) ; Millerová, Ivana (referee)
- Position and activities of the Czech Bar Chamber The topic of my thesis is "Position and activities of the Czech Bar Chamber". The purpose of the thesis is to analyze the role, importance and functioning of the professional chamber which associates over of 12 000 attorneys. I have chosen this particular topic as I think the available literature dealing with professional chambers, particularly the Czech Bar Association (hereinafter CBA) is not up-to- date and does not comprehensively cover the current status of this institution. In addition to the descriptive passages the thesis includes statistical data analysis, reflections on the current state of the CBA and its possible transformation. The thesis is composed of five chapters; the first chapter is a brief introduction to the issue of self-government. It covers what this term means, explains the dividing of self- government and focuses on describing the related terms. The second chapter provides an insight into the history of attorney self-government. Its formation and development is presented including the production of relevant legislation from the late 19th century through the period of the first Republic of Czechoslovakia, to the era of the destructive socialist regime until the post-revolutionary renaissance of freedom of advocacy. The key...
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Legal protection of cultural heritage in the Czech Republic
Bauerová, Veronika ; Svoboda, Petr (advisor) ; Millerová, Ivana (referee)
A few words of introduction (Abstract) In addition to analyzing the concepts of culture, cultural heritage, this thesis mainly deals with the issue of state monument care regulated by the act no. 20/1987 Coll., on State Monument Care, as amended, which is currently valid legislation providing protection cultural monuments and other objects. Since the cultural heritage not only cultural monuments and other objects protected by the act no. 20/1987 Coll., deal with the next part cultural objects, which are regulated by the act no. 71/1994 Coll., on Sale and Export of Cultural Value, as amended, marginally deals with the archival documents as stipulated in the act no. 499/2004 Coll., on Archives and Records Service and amending certain laws, as amended, and museum collections (the collections) which are subject to regulation by act no. 122/2000 Coll., on Protection of Museum Collections and amending certain other acts, as amended. I believe that this work makes sense, because a student or potentional readers may help to understand and summarize the issue of protection of cultural heritage, also may aid in interpretation of the act no. 20/1987 Coll. and also can serve in the future comparison with currently debated new act on the protection of the heritage fund, which is fully replace the applicable legislation.
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Application proceedings for long-term residence permit for business purpose
Sigmundová, Iva ; Svoboda, Petr (advisor) ; Kryska, David (referee)
The aim of this thesis is an interpretation on the administrative procedure concerning an application of the third-country nationals for long-term residence permit for business purpose on the bases of the act nř 326/1999 Coll., On the residence of foreign nationals in the Czech Republic and about amendment of certain acts. The thesis is divided into four parts. The first part contains the interpretation of key terms (foreign nationals, long- term residence permit and business purpose) which determine the long-term residence permit for purpose in question. The second part deals with conditions to be met for submission of the application form and on requirements needed to be attached to the application form. The third part deals with the administrative procedure after submission of application form focusing on particularities of application proceedings for long-term residence permit for business purpose. The fourth part asses the issuing of final decision.
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Aim and purpose of the migration-related detention
Vítová, Šárka ; Kryska, David (advisor) ; Svoboda, Petr (referee)
The aim of the thesis is to answer the following question: What is the aim and the purpose of the migration-related detention? The question is further specified in four sub-questions provided in the introduction. Given that the essence of the detention is the deprivation of personal liberty as one of the fundamental human rights, the practice of detaining migrants in the Czech Republic seems to be in conflict with the personal liberty guarantees stipulated by the constitutional laws of the country, the Charter of Fundamental Rights of the European Union and several international human rights treaties. Resolutions of this conflict requires that such conditions are identified, under which the restriction of personal liberty is permissible. The list of conditions is provided in the thesis, including a legitimate purpose of the restriction of the fundamental right. Any restrictive practice must be capable of achieving this purpose and must not be misused for a purpose other than this. Subsequently, the thesis identifies aims of the different types of migrated-related detention, provided by the Czech laws - the Police Act, Aliens Act and the Asylum Act. The immediate aim pursued by detaining an alien is often to prevent him from obstructing a particular legal proceeding or action. The thesis also deals with the...
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Status and operation of Intelligence Services in the Czech Republic (legal aspects)
Bezděk, Tomáš ; Handrlica, Jakub (advisor) ; Svoboda, Petr (referee)
Position and activities of intelligence services in the Czech Republic (legal aspects) This thesis aims for coherent description of legal aspects of the status and activities of the three intelligence services of the Czech Republic which are Security Information Service, Office for Foreign Relations and Information and Military Intelligence. The thesis is based on legislation effective on January 1, 2016 but it also reflects the historical development of the legislation in this area since early nineties of the 20th century. It also outlines the possibilities of legislation in the future. The thesis is based on publicly available sources especially from legislation, judicial decisions of the Constitutional Court of the Czech Republic, secondary legislation, literature and scientific articles and web pages of the intelligence services. The thesis is divided into eight main chapters. The introductory chapter is focused on the definition of the most important notions in this area - notably the intelligence service, intelligence information and intelligence cycle. The second chapter describes the development of the intelligence services in the former Czechoslovakia and in the Czech Republic between 1918-1994. The third chapter is devoted to general characteristics of intelligence services of the Czech...
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Regulation of lobbying in the Czech Republic including a proposal de lege ferenda
Kislingerová, Gabriela ; Svoboda, Petr (advisor) ; Rajchl, Jiří (referee)
Regulation of lobbying in the Czech Republic including a proposal de lege ferenda Transparent lobbying and his regulation is natural and necessary part of functioning of democratic states. Regulation of lobbying done by legislation is supposed to be a fundamental element of transparency of democracies in 21st century; an essential element of an integrated system of development in approximation of civil society and public institutions, mutual trust and transparency in mutual relations. Regulated lobbying should enable citizens of a democratic society to exercise their right to public control of processes associated with the formation of laws, legal norms of lesser legal force and other important decisions. This thesis describes the current situation (March 2016) in the regulation of lobbying in the Czech Republic and choses, by author, suitable alternatives of solution to the lobbying regulation in the future. Due to the fact that lobbying is not regulated or defined by any law in the Czech Republic, lobbying is often pejoratively confused with corruption and generally misunderstood and negatively perceived by the public. The aim of the thesis is to present possible views on the solution to the problematic of regulation of lobbying in Czech Republic. The thesis is divided into two chapters. The...
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