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Cam-shaft replacement of crank-shaft powertrain of combustion engine
Suk, Jakub ; Blaťák, Ondřej (referee) ; Zháňal, Lubor (advisor)
Diploma thesis deal with possibility cam-shaft replacement of crank-shaft powertrain of combustion engine. In exordium work are designed basic engine data herewith type powertrain. Subsequently is designed several types stroke curves of lobe, after needs on course stroke. Further is in work elaborate engineering design body motor, in detail is solve construction body lobe. In last of capitol is evulate functionality virtual model. At the close are reviewed record and compared benefits and disavantages such engine type.
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Induction of heme oxygenase and biological role of its metabolic products.
Šuk, Jakub ; Muchová, Lucie (advisor) ; Jirsa, Milan (referee) ; Neužil, Jiří (referee)
Heme oxygenase (HMOX) catalyzes first and rate-limiting step in heme degradation. By its action, carbon monoxide (CO), ferrous iron and biliverdin which is subsequently reduced to bilirubin are produced. Before discovery of HMOX reaction mechanism, CO was considered only a toxic waste product without any significant importance for human organism. Bilirubin, marker of liver dysfunction, has been also exposed to similar perception. But results from past decades show that HMOX and its metabolic products play an important role in number of physiological as well as defense against pathophysiological processes. The aim of this thesis was to clarify the role of HMOX and its metabolic products, presumably CO and bilirubin, in vivo and in vitro. We focused on the role of CO in a rat model of lipopolysaccharide-induced cholestasis. We were first to describe tissue distribution and pharmacokinetics of inhaled CO in this animal model and found out that CO inhalation is associated with anti-inflammatory and hepatoprotective effects. In a rat model of ethinylestradiol-induced cholestasis, we demonstrated the anticholestatic effect of HMOX. The induction of HMOX by its substrate heme increased the expression of liver transporters thereby increasing bile flow and simultaneously facilitated effective clearance of...
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Cam-shaft replacement of crank-shaft powertrain of combustion engine
Suk, Jakub ; Blaťák, Ondřej (referee) ; Zháňal, Lubor (advisor)
Diploma thesis deal with possibility cam-shaft replacement of crank-shaft powertrain of combustion engine. In exordium work are designed basic engine data herewith type powertrain. Subsequently is designed several types stroke curves of lobe, after needs on course stroke. Further is in work elaborate engineering design body motor, in detail is solve construction body lobe. In last of capitol is evulate functionality virtual model. At the close are reviewed record and compared benefits and disavantages such engine type.
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