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Synthesis of the 3rd generation of photosensitizers based on azaphthalocyanine core
Stará, Vendula ; Zimčík, Petr (advisor) ; Opletalová, Veronika (referee)
CHARLES UNIVERSITY IN PRAGUE FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ DEPARTMENT OF PHARMACEUTICAL CHEMISTRY AND DRUG CONTROL Title: Synthesis of the 3rd generation of photosensitizers based on azaphthalocyanine core. Author's name: Vendula Stará Year: 2009 Abstract: Photodynamic therapy (PDT) is a new significant treatment modality for several diseases, most notably cancer. Light, oxygen and photosensitizing drug (PS) are combined to produce a selective therapeutic effect. An important breakthrough in PDT is searching for a new PS, modification of their photophysical and optical properties. In this my diploma thesis I synthesized butyl 2,3-dicyanoquinoxaline-6-karboxylate acid by esterification of carboxyl group through its chloride. I used this butylester to synthesize the symmetric and asymmetric AzaPc. The synthesis of the asymmetric AzaPc with one carboxy group in the structure was not possible, because the separation of A3B congener was strongly adsorbed on silica. Esterification of the carboxy group did not lead to better results. Further, I synthesized symmetric AzaPc with butyloxycarbonyl group on the periphery of makrocycle. I prepared zinc (II) dye from its metal-free derivative which was prepared from magnesium (II) analog.
The Synthesis of Aza-analogues of Phthalocyanines Precursors
Stará, Vendula ; Zimčík, Petr (advisor) ; Miletín, Miroslav (referee)
CHARLES UNIVERSITY IN PRAGUE FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ DEPARTMENT OF PHARMACEUTICAL CHEMISTRY AND DRUG CONTROL Candidate: Mgr. Vendula Stará Consultant: PharmDr. Petr Zimčík, PhD. Title of thesis: The synthesis of aza-analogues of phthalocyanines precursors Photodynamic therapy (PDT) is a new significant treatment modality for several diseases, particularly cancer. Light, oxygen and photosensitizing drug (PS) are combined to produce a selective therapeutic effect. An important breakthrough in PDT is searching for a new PS, modification of their photophysical and optical properties and modification of their synthesis and synthesis of their precursors. I focused on the synthesis of precursors of type pyrazino[2,3-b]pyrazine by condensation of diaminopyrazine with diketones in my thesis. I prepared dibutylester of 6,7- dicyanopyrazino[2,3-b]pyrazin-2,3-dicarboxylic acid by condensation reaction of dibutylester dioxotartaric acid and 5,6-diaminopyrazin-2,3-dicarbonitril. Prepared precursor was subsequently used in cyclization reaction toenlarged azaphthalocyanine but the reaction failed. Further, I tried to prepare 6,7-dineopentylpyrazino[2,3-b]pyrazin-2,3-dicarbonitril by reactions of 1,2-dineopentylethan-1,2-dione and 5,6-diaminopyrazin-2,3-dicarbonitril and using Grignard reagents in the...
Synthesis of the 3rd generation of photosensitizers based on azaphthalocyanine core
Stará, Vendula ; Opletalová, Veronika (referee) ; Zimčík, Petr (advisor)
CHARLES UNIVERSITY IN PRAGUE FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ DEPARTMENT OF PHARMACEUTICAL CHEMISTRY AND DRUG CONTROL Title: Synthesis of the 3rd generation of photosensitizers based on azaphthalocyanine core. Author's name: Vendula Stará Year: 2009 Abstract: Photodynamic therapy (PDT) is a new significant treatment modality for several diseases, most notably cancer. Light, oxygen and photosensitizing drug (PS) are combined to produce a selective therapeutic effect. An important breakthrough in PDT is searching for a new PS, modification of their photophysical and optical properties. In this my diploma thesis I synthesized butyl 2,3-dicyanoquinoxaline-6-karboxylate acid by esterification of carboxyl group through its chloride. I used this butylester to synthesize the symmetric and asymmetric AzaPc. The synthesis of the asymmetric AzaPc with one carboxy group in the structure was not possible, because the separation of A3B congener was strongly adsorbed on silica. Esterification of the carboxy group did not lead to better results. Further, I synthesized symmetric AzaPc with butyloxycarbonyl group on the periphery of makrocycle. I prepared zinc (II) dye from its metal-free derivative which was prepared from magnesium (II) analog.

See also: similar author names
12 Stará, Veronika
2 Stará, Vladimíra
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