National Repository of Grey Literature 5 records found  Search took 0.01 seconds. 
The .I.v./I.-Src and .I.c./I.-Src tyrosine kinases immunoprecipitated from Rous sarcoma virus-transformed cells display different specificities to three commonly used peptide substrates
Vojtěchová, Martina ; Tuháčková, Zdena ; Hlaváček, Jan ; Velek, Jiří ; Sovová, Vlasta
Using three synthetic peptides widely used for Src kinase activity assays, we detected differences between the affinities of .I.v./I.-Src and .I.c./I.-Src tyrosine kinases immunoprecipitated from the Rous sarcoma virus transformed cells H19.
Activation of the protein kinase B and glycogen synthase kinase-3 signalling pathway during transient differentiation of human colon cancer HT-29 cells
Tuháčková, Zdena ; Šloncová, Eva ; Hlaváček, Jan ; Sovová, Vlasta ; Velek, Jiří
A pathway during transient differentiation of human colon cancer HT-29 cells is signallized by an activation of the protein kinase B and glycogen synthase kinase-3. Their phosphoacceptor sites are reproduced with synthetic peptides.
Activation of the protein kinase B and glycogen synthase kinase-3 signalling pathway during transient differentiation of human colon cancer HT-29 cells
Tuháčková, Zdena ; Šloncová, Eva ; Hlaváček, Jan ; Sovová, Vlasta ; Velek, Jiří
Using synthetic peptides which reproduce phosphoacceptor sites in the molecule of GSK-3, PKB an eIF2B, we found that phosphorylation and activity of PKB increased very early during in vitro differentiation induced by sodium butyrate. This was inhibited by wortmannin, the selective inhibitor of phosphoinositol-3 kinase, indicating that the control of PI3 kinase/PKB/GSK-3 signalling pathway is the early event of transient differentiation of the human colon cancer cells HT-29.
Charakterizace klonů odvozených od kolorektální nádorově buněčné linie HT29
Šloncová, Eva ; Kučerová, Dana ; Vojtěchová, Martina ; Turečková, Jolana ; Tuháčková, Zdena ; Sovová, Vlasta
During our analysis of HT29 cell line we established several clones, which differed in the expression of some molecular markers, e.g. phosphorylation of Src protein, PKCbeta2 activity, CEA-CAM1 expression and in the response to the differentiating effect of sodium butyrate, indicated by activity of alkaline phosphatase

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4 Sovová, Věra
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