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Conversion of the Aero L-60S "Brigadyr" to it's original version L-60
Honzek, Jan ; Soukupová, Jana (referee) ; Imriš, Pavel (advisor)
This bachelor thesis researches the conversion of the Aero L-60 “Brigadyr” to its original version the L-60. The thesis focuses on the legislative and technical aspects of this backward conversion. The first part of the thesis introduces the aircraft Aero L-60 and its individual versions to the reader. Further on the differences of both versions are compared and analysed. The second part of the thesis mainly focuses on the conversion, considering the technical approach to the problem and the administrative necessities for the conversion. The focal point of this bachelor thesis is a comprehendible list of steps necessary for the conversion of the Aero L-60S aircraft to its original version the L-60.
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Adhesive properties of thin layers based on plasticized polyesters
Soukupová, Jana ; Šnejdrová, Eva (advisor) ; Šklubalová, Zdeňka (referee)
CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Technology Name: Jana Soukupova Title of diploma thesis: Adhesive properties of thin layers based on plasticized polyesters Supervisor: PharmDr. Eva Snejdrova, Ph.D. This diploma thesis deals with rheological, adhesive and dissolution properties of thin layers based on the branched polyester of D,L- lactic acid and glycolic acid, plasticized with methyl- salicylate, and loaded with salicylic acid. The theoretical section describes bioadhesion, its mechanism and theories, in vitro adhesive tests focused mainly on the method of rheological synergism, tensile and "wash off" tests. In the experimental section, the flow properties of plasticized polyesters, hydrated mucin from porcin stomach, and their mixtures were studied using absolute rotational rheometer. The analysis of the viscosity curves revealed that plasticized polyesters are Newtonian systems, mucin and its mixtures with polymer have pseudoplastic behaviour. Adhesive properties of the thin layers were established by equation of rheological synergism based on viscosity of polymer, mucin and their mixtures measured at shear rate of 10 s-1 . The adhesive properties of thin layers were also determined using tensile test on rheometer, and evaluated as the...
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The posibilities of the use of facial recognition technology in the context of personal data protection in the EU
Soukupová, Jana ; Svobodová, Magdaléna (advisor) ; Vondráčková, Aneta (referee)
The Possibilities of the Use of Facial Recognition Technology in the Context of Personal Data Protection in the EU Abstract This thesis focuses on the data protection connected to the use of facial recognition technology in the EU. In particular, the purpose of the thesis is to assess under which circumstances and conditions the use of this technology complies with the GDPR. Marginally, the thesis addresses the risks and benefits of facial recognition technology. The thesis is divided into three parts. The first part examines the general data protection framework in the EU, with an emphasis on the protection of biometric data. The aim of this part is to outline the main legal background regarding the protection of biometric data and the general principles of data processing. In particular, the author criticizes the legal definition of biometric data, which does not correspond to the technological reality, and which may be problematic in the case of the application of Article 9 of the GDPR. The second part of the thesis is devoted to facial recognition technology itself, its different types, and applications. An understanding of the technology itself is crucial within this thesis for the correct application of the legal framework. The author also finds it necessary to examine the reasons why this technology...
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Analysis of hereditary genetic variants predisposing to the development of familial forms of ovarian cancer.
Lhotová, Klára ; Soukupová, Jana (advisor) ; Mohelníková Duchoňová, Beatrice (referee) ; Weinberger, Vít (referee)
Ovarian cancer (OC) is the deadliest gynecologic malignancy with a substantial proportion of hereditary cases and a frequent association with breast cancer (BC). Genetic testing facilitates preventive management for carriers of mutations in OC-susceptibility genes. However, the prevalence of germline mutations varies among populations and many rarely mutated OC predisposition genes remain to be identified. We analyzed 219 genes in 1333 Czech OC patients and 2278 population-matched controls (PMC) using next-generation sequencing. Altogether, 427/1333 (32%) patients and 58 /2278 (2,5%) PMC carried pathogenic mutations in 18 known/anticipated OC predisposition genes. Mutations in BRCA1, BRCA2, RAD51C, RAD51D, BARD1 and mismatch repair genes conferred a high OC risk (with OR>5). Mutations in BRIP1 and NBN were associated with moderate risk (both OR ≥2 - <5). BRCA1/2 mutations dominated in almost all clinicopathological subgroups including sporadic borderline tumors of ovary (BTO). Analysis of remaining 201 genes revealed somatic mosaics in PPM1D and germline mutations in SHPRH and NAT1 associating with a high/moderate OC risk significantly; however, further studies are warranted to delineate their contribution to OC development in other populations. Results of this study demonstrate the high proportion...
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Adhesive properties of thin layers based on plasticized polyesters
Soukupová, Jana ; Šnejdrová, Eva (advisor) ; Šklubalová, Zdeňka (referee)
CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Technology Name: Jana Soukupova Title of diploma thesis: Adhesive properties of thin layers based on plasticized polyesters Supervisor: PharmDr. Eva Snejdrova, Ph.D. This diploma thesis deals with rheological, adhesive and dissolution properties of thin layers based on the branched polyester of D,L- lactic acid and glycolic acid, plasticized with methyl- salicylate, and loaded with salicylic acid. The theoretical section describes bioadhesion, its mechanism and theories, in vitro adhesive tests focused mainly on the method of rheological synergism, tensile and "wash off" tests. In the experimental section, the flow properties of plasticized polyesters, hydrated mucin from porcin stomach, and their mixtures were studied using absolute rotational rheometer. The analysis of the viscosity curves revealed that plasticized polyesters are Newtonian systems, mucin and its mixtures with polymer have pseudoplastic behaviour. Adhesive properties of the thin layers were established by equation of rheological synergism based on viscosity of polymer, mucin and their mixtures measured at shear rate of 10 s-1 . The adhesive properties of thin layers were also determined using tensile test on rheometer, and evaluated as the...
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Analysis of hereditary genetic variants predisposing to the development of familial forms of ovarian cancer.
Lhotová, Klára ; Soukupová, Jana (advisor) ; Mohelníková Duchoňová, Beatrice (referee) ; Weinberger, Vít (referee)
Ovarian cancer (OC) is the deadliest gynecologic malignancy with a substantial proportion of hereditary cases and a frequent association with breast cancer (BC). Genetic testing facilitates preventive management for carriers of mutations in OC-susceptibility genes. However, the prevalence of germline mutations varies among populations and many rarely mutated OC predisposition genes remain to be identified. We analyzed 219 genes in 1333 Czech OC patients and 2278 population-matched controls (PMC) using next-generation sequencing. Altogether, 427/1333 (32%) patients and 58 /2278 (2,5%) PMC carried pathogenic mutations in 18 known/anticipated OC predisposition genes. Mutations in BRCA1, BRCA2, RAD51C, RAD51D, BARD1 and mismatch repair genes conferred a high OC risk (with OR>5). Mutations in BRIP1 and NBN were associated with moderate risk (both OR ≥2 - <5). BRCA1/2 mutations dominated in almost all clinicopathological subgroups including sporadic borderline tumors of ovary (BTO). Analysis of remaining 201 genes revealed somatic mosaics in PPM1D and germline mutations in SHPRH and NAT1 associating with a high/moderate OC risk significantly; however, further studies are warranted to delineate their contribution to OC development in other populations. Results of this study demonstrate the high proportion...
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Artificial intelligence as a challenge to private law
Soukupová, Jana ; Kučera, Zdeněk (advisor) ; Frinta, Ondřej (referee)
Artificial intelligence as a challenge to private law Abstract The subject of this master thesis is private law and artificial intelligence. The main goal of this thesis is the analysis of private law aspects of artificial intelligence and the evaluation of current laws regarding this technology. Therefore, the thesis mainly deals with the legal status of artificial intelligence within the current law and the possible granting of the status of an electronic person. It also deals with the issue of appropriate regulation of artificial intelligence in the future. The first part of the thesis is focused primarily on the concept of artificial intelligence, its importance for society and law and its risks. The primary goal of this chapter is to acquaint the reader with the functioning of artificial intelligence as a technology, while considering its differences from other technologies, especially its autonomy. The second part of the thesis is then focused on a critical analysis of artificial intelligence in terms of current law, according to which artificial intelligence can be considered a thing in the legal sense, a product or an author's work. Part of this chapter is also focused on the issue of protection of works or inventions created by artificial intelligence and on the considerations of artificial...
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Adhesive properties of thin layers based on plasticized polyesters
Soukupová, Jana ; Šnejdrová, Eva (advisor) ; Šklubalová, Zdeňka (referee)
CHARLES UNIVERSITY Faculty of Pharmacy in Hradec Kralove Department of Pharmaceutical Technology Name: Jana Soukupova Title of diploma thesis: Adhesive properties of thin layers based on plasticized polyesters Supervisor: PharmDr. Eva Snejdrova, Ph.D. This diploma thesis deals with rheological, adhesive and dissolution properties of thin layers based on the branched polyester of D,L- lactic acid and glycolic acid, plasticized with methyl- salicylate, and loaded with salicylic acid. The theoretical section describes bioadhesion, its mechanism and theories, in vitro adhesive tests focused mainly on the method of rheological synergism, tensile and "wash off" tests. In the experimental section, the flow properties of plasticized polyesters, hydrated mucin from porcin stomach, and their mixtures were studied using absolute rotational rheometer. The analysis of the viscosity curves revealed that plasticized polyesters are Newtonian systems, mucin and its mixtures with polymer have pseudoplastic behaviour. Adhesive properties of the thin layers were established by equation of rheological synergism based on viscosity of polymer, mucin and their mixtures measured at shear rate of 10 s-1 . The adhesive properties of thin layers were also determined using tensile test on rheometer, and evaluated as the...
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