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Phytoextraction of metformin and guanylurea
Kovářová, Kristýna ; Smrček, Stanislav (advisor) ; Petrová, Šárka (referee)
Pharmaceutically Active Compounds include metformin, the most often prescripted drug for a treatment of the diabetes mellitus type 2. Metformin is used in high daily doses (up to 3000 mg per day) and it is eliminated by kidneys in its original non - metabolized form. Metformin is degraded in the wastewater treatment plants to guanylurea. The wastewater treatment plants aren't able to clean the waste water, so metformin and guanylurea enter the environment, especially surface water. This diploma thesis deals with the ability to remove metformin and its environmental metabolite guanylurea via phytoextraction technologies. First experiment was focused on phytoextraction of metformin using 5 plant species - Zea mays L., Pisum sativum L., Avena sativa L., Alternanthera reineckii Mini L. and Staurogyne repens L. Second experiment studied phytoextraction of guanylurea using Zea mays L. and Pisum sativum L. The third experiment deals with the phytoextraction of metformin and guanylurea together using Zea mays L. The media of all plants were contaminated by metformin or guanylurea at different concentration levels. The samples of media were taken in 24 hours intervals during the plant cultivation and the decrease of its concentration were studied by HPLC with UV detection at 233 nm for metformin and 210 nm...
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Phytoextraction of Selected Pharmaceuticals
Hatasová, Nicolette ; Smrček, Stanislav (advisor) ; Soudek, Petr (referee)
The aim of this bachelor thesis is a study of phytoextraction of trazodone which represents the active component of an antidepressant sold under the name Trittico. Trazodone is not completely metabolized in organisms and part of drug is excreted unchanged by urinary system to wastewater. Phytoextraction represents new and economical method used to remove residual concentrations of pollutants in aquatic ecosystems. These substances enter the environment even after previous cleaning in wastewater treatments plants. The removal of pharmaceutical residues is generally not sufficient which is related to development of more effective methods. Plant maize (Zeamays) was used for this experiment in which degradation effectivity was monitored for eight days. Concentrations of trazodone in various cultivations were determined by HPLC. Results showed that selected antidepressant was extracted during the experiment and phytoextractiontook place. Key words: phytoextraction, wastewater treatment plants, wastewater, pollution, antidepressants, trazodone
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