National Repository of Grey Literature 151 records found  previous11 - 20nextend  jump to record: Search took 0.00 seconds. 
Polymeric nanomaterials for targeted inhibition of tumor growth
Šťastná, Katarína ; Etrych, Tomáš (advisor) ; Sedláček, Ondřej (referee)
Galectins are carbohydrate binding lectins which possess many biological activities related to the development and progression of cancer. The purpose of this bachelor's thesis is synthesis, physico- chemical and in vitro preliminary biological evaluation of novel glycopolymers with high affinity to galectin-3. Several biocompatible water-soluble linear and diblock N-(2- hydroxypropyl)methacrylamide (HPMA) copolymers bearing multivalently presented glycomimetic ligands, were synthesized and characterized by number of analytical methods, i.e. GPC, UV-VIS spectrometry, DLS and NMR. The polymer carriers were synthesized by the controlled RAFT polymerization, their molecular weight ranged from 25,000-33,000 g/mol and showed quite low dispersity. Glycopolymers containing about 4 mol% of glycomimetic ligands showed high ability to inhibit apoptosis of T lymphocytes in vitro. Nevertheless, the hypothesis consisting in the improvement of biological activity due to the denser ligand presentation on diblock copolymers was not proved. The thesis concludes that the prepared glycopolymers, linear as well as diblocks, could hypothetically be convenient tools for synergic therapy with polymer drug delivery systems in cancer treatment. Keywords: polymers, HPMA copolymers, drug-free macromolecular therapeutics,...
Long-term population trends in urban birds in Europe and Czechia
Grünwald, Jan ; Reif, Jiří (advisor) ; Sedláček, Ondřej (referee)
Urbanization ranks among the most important processes induced by the human civilization that affects ecological communities at the same time. Birds are the most frequently studied organisms in relation to urbanization. Different birds' species show different abilities to adapt to urban areas, so urbanization works as an environmental filter. As urban environment undergoes extraordinarily high rate of change, the characteristics of the environmental filter are changing rapidly, too. This could influence populations of urban bird species. We can expect that the population change of the species will be related to the time since urbanization; specifically, the early urban colonizers will decline due to alteration of urban environment, while the recent urban colonizers will increase. I obtained data on population trends from 2000 to 2016 for 95 common urban bird species in 16 European countries. Thanks to the cooperation with local expert ornithologists, I collected the data about the time since urbanization of these species in respective countries and I related these two variables filtering out the influence of 9 other species-specific ecological characteristics. Bird population trends had a statistically significant relation to the time since urbanization: the species that became urbanized earlier...
Moths as nocturnal pollinators in the tropics
Barták, Michal ; Tropek, Robert (advisor) ; Sedláček, Ondřej (referee)
in English In this thesis, I reviewed the available knowledge on the role of moths in the pollination of flowering plants in tropical ecosystems. Moths appeared as relatively frequent visitors of flowers with moth-attracting adaptations. Moths were proved to be essential pollinators of some specialized plant species. An obligatory mutualism with micromoths was found in more than 550 highly specialized plant species. Macromoths appeared as effective pollinators of numerous tropical shrubs, trees, and herbs from numerous plant families. Moths were the only recorded visitors and/or pollinators in several cases. In communities, plant species with moth pollination syndromes were relatively uncommon, and moths were generally infrequent visitors of their flowers, which could also be affected by abiotic factors. The proportion of actually moth-pollinated plant species in communities was even slightly lower than the proportion of plants with moth pollination syndromes in other areas. Some moths (e.g., hawkmoths) can thieve nectar from virtually any shorter-spurred/tubed flowers with their long proboscis. Other moths were reported as nectar thieves in some too accessible flowers. However, moths were reported to be rare nectar thieves and prefer visiting the flowers they also pollinate. This thesis should...
Information Fusion for Classification of Network Devices
Sedláček, Ondřej ; Tisovčík, Peter (referee) ; Žádník, Martin (advisor)
This work is focused on solving information fusion when dealing with multiple data sources in computer network monitoring. A solution built on the concept of classification rules configured by experts is presented. Configuration is simplified using a designated configuration language interpreted by the solution. The classification rules enable coverage of diverse types of data. The result is given as a label from specified taxonomy. Using a taxonomy maintains the different levels of detail between the data sources, even in the output label. The solution also uses the Dempster-Schafer theory for merging labels from different sources into a single output label. Results of experiments show that information fusion in this context does increase the accuracy of device classification. A process of rule optimization was developed based on testing and experiments with a dataset from a real network. The accuracy was increased by 19 % compared to the original solution using this process.
Preparation and implementation of construction and technical survey of prestressed bridge structure
Kubová, Klaudie ; Sedláček, Ondřej (referee) ; Anton, Ondřej (advisor)
The bachelor's thesis deals with the technical survey of the load-bearing structure of the left part of prestressed motorway bridge D2-058..2. The bridge is located on the border between the Czechia and Slovakia, and it was built in 1980. The work is focused on locating the prestressing reinforcement of prefabricated beams and determining its condition. The theoretical part describes the principle of static action of reinforced and prestressed concrete, categorization of technical surveys of structures and diagnostic methods. The work also presents specific diagnostic methods for determining the position and condition of prestressing reinforcement. In the practical part, the work deals with the analysis of beams by means of ground penetrating radar and probes for analysis of the condition of reinforcement. The outcome of the work is a study of the deviations of the position of prestressing cables from the original project documentation and determination of their condition in terms of corrosion degree and grouting.
Porous polymer networks prepared from ethynylpyridines
Titlová, Štěpánka ; Sedláček, Jan (advisor) ; Sedláček, Ondřej (referee)
Series of new micro/mesoporous polymer networks with high content of pyridine segments was prepared. For the preparation were used ethynylpyridine type of monomers which were successfully homopolymerized and copolymerized with hydrocarbon diethynylarenes by chain-growth coordination polymerization catalyzed with [Rh(NBD)acac] complex. Polymerizations provided polyacetylene networks with main chains densely cross- linked by pyridine or arylene links. Prepared pyridine networks showed specific surface area SBET from 308 m2 /g to 923 m2 /g and variable content of pyridine segments in an interval from 3,27 mmol/g to 7,86 mmol/g. In networks, pyridine segments made part of interchain links or side groups. Networks with pyridine segments were successfully quaternized by heterogeneous postpolymerization reaction with bromoethane to form well covalently defined networks containing N-ethylpyridinium segments. Quaternized networks containing pyridinim segments in amount from 2,41 mmol/g to 4,24 mmol/g had preserved micro/mesoporous texture with values of SBET from 331 m2 /g to 592 m2 /g. Polyacetylene networks with N-ethylpyridinium segments were prepared also by catalyst-free (spontaneous) quaternization polymerization of diethylpyridines. These networks were worse covalently defined and had proved lower...

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