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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Endothelial dysfunction, cell adhesion molecules and their relationship to atherogenesis.
 Bajerová, Monika ; Nachtigal, Petr (advisor) ; Pospíšilová, Naďa (referee)
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Adhesion Molecules and their Role in Model of Pathological Conditions
 Pospíšilová, Naďa ; Semecký, Vladimír (advisor) ; Geršl, Vladimír (referee) ; Stingl, Josef (referee)
Souhrn/Summary 1 Atherosclerosis is one of the major causes of cardiovascular morbidity. This chronic inflammatory disease is characterized by endothelial dysfunction with accumulation of lipids, leukocytes, smooth muscle cells and extracellular matrix within the vessel intima. This process results in reducing of the vessel lumen that can lead to the obstruction of vessel blood flow. The initiation of atherogenic process is characterized by the alteration of endothelial function which is so-called endothelial dysfunction. The endothelial dysfunction is characterized by the expression of cell adhesion molecules and increased endothelial permeability for monocytes, T-cells and lipoproteins. This is beginning of "vicious"circle of atherosclerosis. On of the most important cell adhesion molecules participating in the beginning of atherogenesis are members of the immunoglobulin superfamily, VCAM-1 (vascular cell adhesion molekule-1), ICAM-1 (intracellular cell adhesion molekule-1) and PECAM-1 (platelet-endothelial cell adhesion molekule-1).VCAM-1 and ICAM-1 are transmembrane glycoproteins participacing predominantly in the stabilization leukocyte of interaction with endothelium and transmigration of leukocytes into vessel intima. In this dissertation thesis, the first studies were focused on the endothelial...
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See also: similar author names
1 POSPÍŠILOVÁ, Nicole
5 POSPÍŠILOVÁ, Nikola
2 Pospíšilová, Nikol
5 Pospíšilová, Nikola
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