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Economy of Catalonia and possible consequences of its eventual independence from Spain
Polák, Milan ; Hinčica, Vít (advisor) ; Bolotov, Ilya (referee)
The aim of this thesis is to analyse important aspects of separatism in Catalonia. Thesis is comprised of three chapters and conclusion. The first chapter addresses the historical origins of Catalan attempts to gain independence, legal and political issues and further examines current situation in the autonomous community. The second chapter analyses the problem from economic point of view. Spanish and Catalan economies will be examined alongside with their economic relationship. The third chapter is relevant factors that might play an important role in cause of eventual separation: the form of gaining an independence, viability of a new Catalan economy and possible scenarios of relationships between Catalonia, Spain and the European union. In the end author summarizes the problem and provides conclusions.
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Immunophenotype differences in non-memory B lymphocyte populations in healthy controls and patients with immunopathologies
Polák, Milan ; Růžičková, Šárka (advisor) ; Šplíchal, Igor (referee)
B-lymphocytes are a subset of immune cells that can be distinguished mainly by carrying clonally diversified membrane-bound immunoglobulin specialized to specific antigen recognition. Together with other immunocytes B-lymphocytes play a central role in adaptive immune system which takes part in defense of the host against wide variety of pathogens. Recently the evidence has supported the emerging concept of different B-cell subpopulations to play a direct or indirect role in a pathogenesis of spectrum of disorders. However, so far the knowledge has been limited mainly in the way of how the specific differentiation stages of B-lymphocytes are involved in pathogenesis of diseases and how course of disease, stage, and eventually different treatment can affect B-cell homeostasis. That is the reason for the thesis to be focused on an analysis of B-cell population profile changes in disease, identification of any association present among specific B-cell subpopulations, as well as association between these subpopulations and clinical parameters. Using polychromatic flow cytometry we analyzed frequencies of 11 B-cell subpopulations including stages of transient B-lymphocytes through effector antibody-producing plasma cells. We examined 81 individuals including 22 healthy controls and 59 patients with...
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