National Repository of Grey Literature 14 records found  1 - 10next  jump to record: Search took 0.00 seconds. 
Kinetically guided therapy with gentamicin in neonates with sepsis during the first week of life
Pokorná, Pavla ; Chládek, Jaroslav (advisor) ; Perlík, František (referee) ; Patočková, Jitka (referee)
Gentamicin (Ge) belongs to the group of aminoglycoside antibiotics frequently used in the treatment of neonates with sepsis in combination with betalactams. The first part of the disertation investigates a kinetically guided therapy with gentamicin (Ge) and the impact of covariates on pharmacokinetics/pharmacodynamics (PK/PD) while the second part describes the tolerability of treatment. This open-label, prospective study included preterm and term neonates (n=108) who experienced critically illness during the first week of life and were treated with Ge and admitted to the neonatal intensive care unit. The primary goal of the study was to perform a pharmacokinetic study after the first dose of Ge. The influence of covariates on PK was analyzed (body weight, gestational age-GA, fluid retention, persistent ductus arteriosus-PDA, postnatal age, therapeutic hypothermia-HT) as well as the success rate in the achivement of target therapeutic concentrations in the first week of pharmacotherapy. Fitting of the parameters of two-compartment model to the four plasma concentrations of Ge (CplGe) concentations after the first dose was used to estimate individual PK of Ge: distribution volume (Vd1) and clearance (CL1). Neonates were stratified into four groups according to GA and the presence of a PDA (S1-PDA=18,...
Nursing care of a child after near drowning
Švarcová, Pavlína ; Zvoníčková, Marie (advisor) ; Pokorná, Pavla (referee)
V práci předkládám případovou studii 13. měsíčního batolete s diagnózou stav po tonutí. Pacientka byla hospitalizována na JIRP dětské kliniky fakultní nemocnice. Práce je rozdělena do pěti částí. V klinické části je uvedena obecná charakteristika onemocnění (rozdělení, příčina, příznaky, rozdíly, fáze, patofyziologie, klinický obraz). Dále první pomoc, léčba, prevence a prognóza. Další část jsou základní údaje o nemocné, průběh onemocnění, vyšetřovací metody a terapie . V ošetřovatelské části je popsán ošetřovatelský proces a charakteristika modelu M. Gordonové. Podle tohoto modelu jsem zhodnotila celkový stav pacientky. Stanovila jsem ošetřovatelské diagnózy ve 2. dni hospitalizace, krátkodobý a dlouhodobý plán ošetřovatelské péče. Součástí práce je i psychologická část a kapitola věnovaná edukaci, v tomto případě hlavně rodičům pacientky.
Vztah územního a strategického plánování na příkladu obce Modřice
Pokorná, Pavla
The diploma thesis is divided into two consecutive parts. The first - theoretical part deals with spatial and strategic planning. At the beginning of the practical part, area Modřice described is represented by the primary, secondary and tertiary landscapes structure. Then the processes of creation and characterization of the territorial and strategic plan of Modřice are described. Finally, plans are compared and steps to improve work with documents.
Didaktická pomůcka pro environmetální vzdělávání
Pokorná, Pavla
Bachelor thesis deals with creation of didactic aid for environmental educa-tion. The thesis has theoretical and practical parts. The aim of the theoretical part is to acquire the knowledge from professional sources to clarify the basic con-cepts related to environmental education in connection with the educational paths and didactical aids with a focus on the worksheets and the principles of their cre-ation. The partial aim is to approach the issue and importance of nature trails. The methods used for the theoretical part are analysis, comparison and synthesis. The aim of the practical part of the bachelor thesis is the creation of a worksheet, which will be used in the framework of the already existing educational trail "We Recognize Rajhradsko". The worksheet is processed for the selected part of the nature trail. Another aim of the practical part is to develop a methodical recom-mendation for teachers, how to work with the worksheets and what competencies will be developed for pupils in this activity.
Supporting Programs for Substitute Families with Romany Children
Pokorná, Pavla ; Hajská, Markéta (advisor) ; Kubaník, Pavel (referee)
This bachelor thesis deals with the substituting of family care for children with Roma roots in the Czech Republic. The main focus is the specific support programs for families who adopted Roma children. This thesis maps out existing support programs for the substitute families with Roma children. Three programs have been selected and described in detail, based on interviews with the ones who implement these programs. The description focuses mainly on the following aspects: The way in which Roma culture is explained to the substitute families, sources of information provided by the overseers of programs to the substitute families, and proportion of Roma and non-Roma workers involved in the preparation and implementation of these programs. The perspective of the support programs are supplemented by the reflection of these activities by the participants of the programs. This thesis also includes information on the outlying framework of the given subjects, i.e. the system of substitute child care in the Czech Republic. This thesis also points out the over-represented number of Roma children in group facilities compared to the majority of the population and, at the same time, applicants of substitute family care are unwilling to accept Roma children. This description is enriched with information...
Kinetically guided therapy with gentamicin in neonates with sepsis during the first week of life
Pokorná, Pavla ; Chládek, Jaroslav (advisor) ; Perlík, František (referee) ; Patočková, Jitka (referee)
Gentamicin (Ge) belongs to the group of aminoglycoside antibiotics frequently used in the treatment of neonates with sepsis in combination with betalactams. The first part of the disertation investigates a kinetically guided therapy with gentamicin (Ge) and the impact of covariates on pharmacokinetics/pharmacodynamics (PK/PD) while the second part describes the tolerability of treatment. This open-label, prospective study included preterm and term neonates (n=108) who experienced critically illness during the first week of life and were treated with Ge and admitted to the neonatal intensive care unit. The primary goal of the study was to perform a pharmacokinetic study after the first dose of Ge. The influence of covariates on PK was analyzed (body weight, gestational age-GA, fluid retention, persistent ductus arteriosus-PDA, postnatal age, therapeutic hypothermia-HT) as well as the success rate in the achivement of target therapeutic concentrations in the first week of pharmacotherapy. Fitting of the parameters of two-compartment model to the four plasma concentrations of Ge (CplGe) concentations after the first dose was used to estimate individual PK of Ge: distribution volume (Vd1) and clearance (CL1). Neonates were stratified into four groups according to GA and the presence of a PDA (S1-PDA=18,...
The influence of veno-arterial extracorporeal membrane oxygenation (VA ECMO) on antibiotic concentrations in a animal model
Havelková, Kristýna ; Springer, Drahomíra (advisor) ; Pokorná, Pavla (referee)
In July, August and December was conducted a pilot project investigating the availability of antibiotics to the lungs on the model of piglets treated with VA ECMO. In the study were collected and processed samples from the pulmonary artery, artery, ECMO and BAL. To determine the analytes there were used different analyzers that are capable of conducting the investigation. Most analyzers use the detection limit from the manufacturer. The measured values were lower than those limits, it was important to determine whether they are relevant and therefore usable for further statistical processing. Data from this project was evaluated using the newly calculated limits of detection. Of the total group of 12 piglets all successfully completed the project, 2 of them suffered a pulmonary edema. It was concluded that the use of VA ECMO, despite the apparent reduction in pulmonary flow, does not reduce the concentration of vancomycin, gentamicin or amikacin in pulmonary artery and within one hour after administration of antibiotics can be detected in the tracheal aspirate. .
Nursing care of a child after near drowning
Švarcová, Pavlína ; Zvoníčková, Marie (advisor) ; Pokorná, Pavla (referee)
V práci předkládám případovou studii 13. měsíčního batolete s diagnózou stav po tonutí. Pacientka byla hospitalizována na JIRP dětské kliniky fakultní nemocnice. Práce je rozdělena do pěti částí. V klinické části je uvedena obecná charakteristika onemocnění (rozdělení, příčina, příznaky, rozdíly, fáze, patofyziologie, klinický obraz). Dále první pomoc, léčba, prevence a prognóza. Další část jsou základní údaje o nemocné, průběh onemocnění, vyšetřovací metody a terapie . V ošetřovatelské části je popsán ošetřovatelský proces a charakteristika modelu M. Gordonové. Podle tohoto modelu jsem zhodnotila celkový stav pacientky. Stanovila jsem ošetřovatelské diagnózy ve 2. dni hospitalizace, krátkodobý a dlouhodobý plán ošetřovatelské péče. Součástí práce je i psychologická část a kapitola věnovaná edukaci, v tomto případě hlavně rodičům pacientky.
Lean Six Sigma and its Utilization in Practice
Pokorná, Pavla ; Zelená, Veronika (advisor) ; Váchová, Lucie (referee)
The aim of this work is a detailed introduction to the theory of Lean six sigma management tool and verify its efficacy in practice on the individual case. Process to be improved in this work is recovery of overdue debts on english market of certain international company. Of the possible tools Lean six sigma methodologies were chosen the most suitable for a particular process and main causes of large amounts of overdue recievables were identified. As the best steps to improve the process were indentified sending statements of account to customers, improve communication quality and appealing for compliance maturity according to the rules of English banking system. With the methodology we achieved improvement on Sigma parametr on the researched process.

National Repository of Grey Literature : 14 records found   1 - 10next  jump to record:
See also: similar author names
25 POKORNÁ, Petra
1 Pokorná, P.
10 Pokorná, Pavlína
25 Pokorná, Petra
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