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Symmetrically substituted polyazamacrocycles
Pošívalová, Kateřina ; Lorenc, Miroslav (advisor) ; Drahoňovský, Dušan (referee)
This thesis deals with the synthesis of model compounds and cyclam cyclen macro compounds for the preparation contrast agents of synthetically readily available starting materials. Result, a new macrocycle was prepared which could be used for complexation with GdIII and other measurements. Macrocycle was prepared in low yields (3.2% and 3%) Synthesis was performed 2,5,9,12-tetraazabicyclo [11.3.1] heptadecane-4,10-dione and N2 ,N5 - dibenzyl 2,5,9,12-tetraazabicyclo[11.3.1]heptadecane-4,10-dione for further processing and subsequent measurement of required quantities, which have been formally completed synthesis.
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