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Polyfunctional building
Pavlík, Vojtěch ; Kučera, Radim (referee) ; Fuciman, Ondřej (advisor)
Diploma thesis deals with a new polyfunctional building with in the town Třebíč. The aim of this work is to develop design documents for building construction. It is detached building with five above-ground floors and one basement. Spaces that are used to operate on the first floor and second floor are operationally separated. Three floors are intended for occupancy 30 – 40 persons.
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Design of brake test pedometr
Pavlík, Vojtěch ; Blaťák, Ondřej (referee) ; Vančura, Jan (advisor)
This bachelor thesis is focused on equipment used for measurinng the handling force of braking system, a regulations of homologation tests (by ECE) and inspection checks (by MT) of braking systems. Furthermore, it includes a survey of commercial pedometers and their working principles, its andvanteges and disadvanteges. To end with, the author presents custom pedometer with a calibration device.
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Family business house
Pavlík, Vojtěch ; Berousková, Dana (referee) ; Fuciman, Ondřej (advisor)
Bachelor’s thesis deals with a new family bussines house with design office in the village Kojatín. The aim of this work is to develop design documents for building construction. It is detached building with two floors and terrace. Spaces for design office are disposition separate from residental unit . Two floors are intended for occupancy 4 – 5 persons.
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Investigation of impact of radiant heating and cooling on car driver thermal comfort
Pavlík, Vojtěch ; Tuhovčák, Ján (referee) ; Fišer, Jan (advisor)
This diploma thesis is focused on the matter of radiation heating, thermal comfort maintenance and setting optimal operation parameters for heating system equipped with radiation panels. The research section summarizes the effects most important for thermal comfort, methods of its determination, heat exchange distribution between the human body and its environment, and technical possibilities of heating car interiors. The central points of this work are the simulation of car interiors heated with radiation panels and the evaluation of thermal comfort with a virtual mannequin. Thermal state was determined via the equivalent temperature and thermal comfort zones diagram (method by O.H. Nilsson). Forty-two simulated scenarios led us to conclude that thermal comfort is not possible to obtain with panels exuding a maximum temperature of 43 °C and the combination of several heat sources is required. Nevertheless radiation heating considerably contributes to energy savings without the loss of thermal comfort in assessed car.
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Antimicrobial, cytotoxic, and antiprotease effects of silver used for treatment of infected wounds
Pavlík, Vojtěch ; Arenbergerová, Monika (advisor) ; Pospíšilová, Alena (referee) ; Resl, Vladimír (referee)
Chronic wounds pose a socioeconomic problem and burden to patients worldwide. There are several causes of wound chronicity. One of the major issues of the non-healing state of a wound is its infection. Bacteria provoke a proinflammatory response, which disrupts the proper sequence of wound healing phases. Also, inflammation raises the production and activity of proteases. These enzymes digest the extracellular matrix, resulting in deceleration or hindrance of granulation tissue maturation. In addition to the inflammation-induced proteases, some bacterial species produce proteases that contribute to tissue degradation and increase bacterial virulence. Antiseptics are used to lower the bacterial burden in chronic wounds. Antiseptics act non-specifically, which may be their asset as well as drawback. They act as a double-edged sword. Antiseptics act on bacterial cells. However, host cells are caught in the crossfire as antiseptics may damage eukaryotic cells as well. The damage of eukaryotic cells complicates wound closure. Silver is probably the most used antiseptic to treat chronic wounds. Silver is also suspected of inducing nonspecific damage to eukaryotic as well as prokaryotic cells. This doctoral thesis is aimed at investigating the multitude of effects that silver may exhibit. We chose in vitro...
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The quality of sport-related services in institutions designed for children aged 3-6 years (pre-school education).
Pavlík, Vojtěch ; Ruda, Tomáš (advisor) ; Šíma, Jan (referee)
Title: The quality of sport-related services in institutions designed for children aged 3-6 years (pre-school education). Objectives The quality of objective of this work is to determine the quality of sport-related services in day-care centers in the Czech Republic. Methods: This marketing research is going to be conducted using standardized methods of SERVQUAL in the form of a written questionnaire, which is going to be left to the principals of selected day-care centers who will further hand it to the parents of the children. Results: The results of this marketing research show that neither of the two nurseries provides such good sport services so that the parents were fully satisfied. The day-care center of Matjuchinova in Zbraslav presented itself with the better results. The results of the second institution - the day-care center of Psáry - turned out very badly and many of the local provided sports services can be described as poor. Key words: SERVQUAL, questionnaire, marketing research, day-care centers
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Design and construction of Src biosensor
Pavlík, Vojtěch ; Rösel, Daniel (advisor) ; Brdička, Tomáš (referee)
Src kinase is a well-known proto-oncogene that contributes to cell migration and proliferation and is often found deregulated in tumors. Yet, biology of Src is not fully understood and great effort is made to find new tools for broadening knowledge about the kinase. In this thesis is described design and construction of a novel Src biosensor that exploits genetically encodable fluorophores derived from green fluorescent protein and Förster/fluorescence resonance energy transfer (FRET). The fluorophores are inserted directly into the structure of full-length c-Src in the way that should not impair the inner regulatory mechanisms of Src. The created biosensor proved to be sensitive to various stimuli, which also activate c-Src, by increase of activating autophosphorylation on Tyr4162 and decrease in FRET. Preliminary experiments indicate that the Src biosensor can be used to reflect Src activation in fixed cell as well.
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Cytototoxic effects of antiseptics in devices for chronic wound healing
Kejzlarová, Leona ; Pavlík, Vojtěch (advisor) ; Hrdý, Jiří (referee)
Chronic wounds are often colonized by pathogens bacteria. The occurrence of infection on the surface results in an injured and delayed healing process. Therefore, the use of antimicrobial agents that eliminate microbiological stress and prevent infection is required for the treatment of chronic wounds. Microbial agents include antibiotics, but pathogens are able to develop resistance to them. Antiseptic agents are therefore used, which act non-selectively. Antiseptics may be cytotoxic to human tissue cells and cause a delay in wound healing. A certain balance needs to be struck between antimicrobial activity and cytotoxicity. The most commonly used active substances with microbicidal properties in antiseptic preparations are: silver, iodine, chlorine, octenidine, polyhexanide, and chlorhexidine. This work describes the mechanisms of action of these agents and compares the clinical and laboratory knowledge of their effectiveness in chronic wound healing and cytotoxicity against cells involved in this process. Keywords: Chronic wounds, antiseptic, cytotoxicity, octenidine, chlorhexidine, polyhexamethylen, PHMB, iodine, silver, chlor
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Investigation of impact of radiant heating and cooling on car driver thermal comfort
Pavlík, Vojtěch ; Tuhovčák, Ján (referee) ; Fišer, Jan (advisor)
This diploma thesis is focused on the matter of radiation heating, thermal comfort maintenance and setting optimal operation parameters for heating system equipped with radiation panels. The research section summarizes the effects most important for thermal comfort, methods of its determination, heat exchange distribution between the human body and its environment, and technical possibilities of heating car interiors. The central points of this work are the simulation of car interiors heated with radiation panels and the evaluation of thermal comfort with a virtual mannequin. Thermal state was determined via the equivalent temperature and thermal comfort zones diagram (method by O.H. Nilsson). Forty-two simulated scenarios led us to conclude that thermal comfort is not possible to obtain with panels exuding a maximum temperature of 43 °C and the combination of several heat sources is required. Nevertheless radiation heating considerably contributes to energy savings without the loss of thermal comfort in assessed car.
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