National Repository of Grey Literature 8 records found  Search took 0.01 seconds. 
Buried bumper syndrome - a complication of percutaneous endoscopic gastrostomy
Cyrany, Jiří ; Kopáčová, Marcela (advisor) ; Dítě, Petr (referee) ; Procházka, Vlastimil (referee)
Percutaneous endoscopic gastrostomy is a widely used method of nutrition delivery for patients with long-term insufficiency of oral intake. Buried bumper syndrome belongs to severe complications of this method, in which the internal fixation device migrates along the tract of the stoma outside the stomach. Even though all the precautions are respected - including adequate positioning of the outer fixator - this complication does occur. The buried bumper syndrome can be managed surgically or endoscopicaly in many modifications. Published series of this syndrome are not robust enough; they differ in its incidence. Some published results indicate increase of the incidence in time, however there is no explanation for this change. Until now there is no universal diagnostic and therapeutic algorithm based on the degree of disc submersion determined by reliable and feasible methods. Dissection of the overgrowing tissue is the determinant for a successful endoscopic therapy, nevertheless methods described until now are clumsy and bear a significant risk of complications such as bleeding and perforation. Forty cases of the buried bumper syndrome in 38 patients were identified in this study based on the retrospective analysis of 1248 procedures with percutaneous endoscopic gastrostomy implantation during...
Pathophysiology of inflammatory bowel disease. Relation to primary scklerosing cholangitis, liver transplantation and carcinogenesis.
Bajer, Lukáš ; Drastich, Pavel (advisor) ; Živný, Jan (referee) ; Procházka, Vlastimil (referee)
Inflammatory bowel disease (IBD) represents a group of multifactorial illnesses with increasing incidence worldwide. Crohn's disease (CD) and ulcerative colitis (UC) are the two most thoroughly defined phenotypes of IBD. IBD associated with primary sclerosing cholangitis (PSC) - a progressive biliary disease leading to cirrhosis and liver failure - is considered as specific IBD phenotype (also referred to as 'PSC - IBD') due to its clinical and pathophysiological characteristics. The aim of the experimental part of this thesis was to define specific features of PSC - IBD in the key areas of IBD pathogenesis. These are: microbiota composition, gut - barrier failure, genetic predisposition and aberrant cellular and antibody immune response. Furthermore, the other goals were to describe relation of IBD status and activity to liver transplantation (LTx) and carcinogenesis based on thorough analysis of clinical data in patients under surveillance at the liver transplantation unit. Using the next-generation parallel sequencing technology, we discovered specific bacterial and mycobial features of gut microbiota composition in PSC - IBD which significantly differed from UC and healthy controls recruited from Czech general population. Moreover, we identified numerous seral biomarkers distinguishing CD, UC...
Study of new prognostic markers in patients with chronic lymphocytic leukemia
Vrbacký, Filip ; Červinka, Miroslav (advisor) ; Pospíšilová, Šárka (referee) ; Procházka, Vlastimil (referee)
3 Summary Title: Study of new prognostic markers in patients with chronic lymphocytic leukemia Chronic lymphocytic leukemia (CLL) is the most common leukemic disorder of adults in Western hemisphere. It is characterized by clonal proliferation and accumulation of morphologically mature lymphocytes in bone marrow, peripheral blood and lymphatic tissues. Clinical course of CLL is extremely heterogeneous with some patients living for decades without need of therapy while others succumbing to the disease within several years. Thus, there has been great interest in identifying prognostic markers that could be used to distinguish patients with an aggressive form of CLL, because they might benefit from early intervention. The process of angiogenesis has been shown to be crucial for growth and metastasizing ability of solid tumors. Angiogenesis in "liquid" tumors was supposed to be less important, nevertheless numerous recent studies have shown enhanced angiogenesis in many hematological malignancies including CLL. Elevated levels of circulating angiogenic cytokines and increased expression of genes encoding angiogenic factors have been reported in recent years in patients with chronic lymphocytic leukemia (CLL) but data regarding their prognostic and predictive significance are still limited. Therefore, in the...
Buried bumper syndrome - a complication of percutaneous endoscopic gastrostomy
Cyrany, Jiří ; Kopáčová, Marcela (advisor) ; Dítě, Petr (referee) ; Procházka, Vlastimil (referee)
Percutaneous endoscopic gastrostomy is a widely used method of nutrition delivery for patients with long-term insufficiency of oral intake. Buried bumper syndrome belongs to severe complications of this method, in which the internal fixation device migrates along the tract of the stoma outside the stomach. Even though all the precautions are respected - including adequate positioning of the outer fixator - this complication does occur. The buried bumper syndrome can be managed surgically or endoscopicaly in many modifications. Published series of this syndrome are not robust enough; they differ in its incidence. Some published results indicate increase of the incidence in time, however there is no explanation for this change. Until now there is no universal diagnostic and therapeutic algorithm based on the degree of disc submersion determined by reliable and feasible methods. Dissection of the overgrowing tissue is the determinant for a successful endoscopic therapy, nevertheless methods described until now are clumsy and bear a significant risk of complications such as bleeding and perforation. Forty cases of the buried bumper syndrome in 38 patients were identified in this study based on the retrospective analysis of 1248 procedures with percutaneous endoscopic gastrostomy implantation during...
Barrett's oesohagus: prevalence and complications in 10 year period
Al -Tashi, Mohamed Mohamed Mohamed ; Bureš, Jan (advisor) ; Kotrlík, Jan (referee) ; Procházka, Vlastimil (referee)
SUMMARY: Barretťs oesophagus is a complication of gastro-oesophageal reflux disease. It is defined as a incomplete intestinal metaplasia. The relevance of this matter is, that Barretťs oesophagus is pre-malignant status. Aim of the study was to analyze retrospective data of upper GI endoscopies in a single centre within 10 years period. A total of 520 (4.6%) cases of Barrett's oesophagus were found out of 18.276 upper gastrointestinal endoscopies, performed in 11.276 patients at a single tertiary centre in a period from 1994 to 2004.. Out of total number of patients there were 348 males (67 %) and 172 females (33 %), the ratio males : females was 2 : 1.

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