National Repository of Grey Literature 125 records found  1 - 10nextend  jump to record: Search took 0.00 seconds. 
Návrh právní úpravy efektivní péče o krajinu: Výsledky promítnuté do právních předpisů a norem (Hleg). Popis metod, dosažených původních výsledků výzkumu a důvodová zpráva
Novák, Zdeněk ; Zámečník, Roman ; Volfová, Andrea
Cílem zpracování návrhu právního předpisu (Hleg) bylo, v souladu s výzkumným projektem a v souladu se Státní kulturní politikou na léta 2015–2020 s výhledem do roku 2025, která stanoví v opatření 3.1.2 Legislativně zajistit odpovídající správu vybraných území se soustředěnými kulturními hodnotami, navrhnout text právního předpisu a příslušnou důvodovou zprávu, jež zefektivní správu vybraných území se soustředěnými kulturními hodnotami. V kontextu tohoto cíle byla navržena novelizace zákona č. 20/1987 Sb., o státní památkové péči, ve znění pozdějších právních předpisů.
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Analysis of the structure of alkaloids using multidimensional NMR spectroscopy
Novák, Zdeněk ; Kuneš, Jiří (advisor) ; Šimůnek, Petr (referee) ; Šaman, David (referee)
This Thesis was focused on the structural analysis employing nuclear magnetic resonantion (NMR) of unknown natural substances, which were isolated at the Department of Pharmaceutical Botany and Ecology from the plants Berberis vulgaris L., Fumaria officinalis L. and Nerine bowdenii W. Watson. For this purpose, 1D (1 H NMR, 13 C NMR) and 2D (gCOSY, gHSQC, gHMBC, NOESY, …) NMR spectra were measured and interpreted. Isotopic induced effect was optimized for the determination of the constitutional isomers. To distinguish the possible stereoisomers Mosher method, chiral shift reagent, nuclear Overhauser effect, indirect spin-spin coupling and circular dichroism were used. The structures of forty- five alkaloids were determined including their absolute configuration. Ten of them have not been yet mentioned in the literature before.
The significance of the S100B protein in patients with an injury to the central nervous system
Lavička, Pavel ; Choc, Milan (advisor) ; Náhlovský, Jiří (referee) ; Novák, Zdeněk (referee) ; Sameš, Martin (referee)
Inroduction: The S100B protein is a small dimeric protein which belongs to a group of calcium binding proteins. It is found in astroglial cells in the central nervous system (CNS). The S100B protein is detected, at very low concentrations, in fat tissue, muscle and bone marrow. We can measure this marker in the cerebrospinal fluid, in serum and in urine. The commercially available assay measures the sum of two different dimers (the S100A1B and S100BB) which collectively are called the S100B protein.The level of this marker increases significantly in patiens with CNS damage. Studies of patients with isolated head trauma have demostrated a correlation between serum marker level, neurological findings and outcome. In patients with polytrauma there is a problem to evaluating the initial S100B protein level with regards to CNS damage, because the S100B protein level can be affected by extracerebral sources of the S100B protein. Aim of study: The aim of our study was to evaluate the significance of the S100B protein in patiens with either isolated head trauma or polytrauma and to evaluate the significance of the initial level and the significance of dynamic monitoring of the S100B protein levels. The importace of these levels for predicting primary CNS damage, and for making a prognosis of such patiens...
Analysis of the structure of alkaloids using multidimensional NMR spectroscopy
Novák, Zdeněk ; Kuneš, Jiří (advisor) ; Šimůnek, Petr (referee) ; Šaman, David (referee)
This Thesis was focused on the structural analysis employing nuclear magnetic resonantion (NMR) of unknown natural substances, which were isolated at the Department of Pharmaceutical Botany and Ecology from the plants Berberis vulgaris L., Fumaria officinalis L. and Nerine bowdenii W. Watson. For this purpose, 1D (1 H NMR, 13 C NMR) and 2D (gCOSY, gHSQC, gHMBC, NOESY, …) NMR spectra were measured and interpreted. Isotopic induced effect was optimized for the determination of the constitutional isomers. To distinguish the possible stereoisomers Mosher method, chiral shift reagent, nuclear Overhauser effect, indirect spin-spin coupling and circular dichroism were used. The structures of forty- five alkaloids were determined including their absolute configuration. Ten of them have not been yet mentioned in the literature before.
The correlation of intracranial pressure and next investigative parameters at the cerebral contusion
Škúci, Ivan ; Choc, Milan (advisor) ; Novák, Zdeněk (referee) ; Smrčka, Martin (referee)
Patients with a brain injury must overcome a central neurological insult and a systematic metabolic response. The systematic response includes hypermetabolism, hypercatabolism, altered vascular permeability, increased hormone and cytokine release, altered gastric emptying, altered mineral metabolism and altered immune status. This response may initiate mechanisms which lead to secondary brain injury and may adversely affect the function of other organs. Last two decades have improved our knowledge of pathophysiology in patients with primary and secondary brain injury including traumatic contusions. In a moment of injury, primary brain injury which is traumatic contusion can not be therapeutically prevented it can only have a preventive effect. Secondary brain injury can be therapeutically affected although both types of injuries have common pathophysiological signs of disturbed metabolism on cells and subcellular level. Research methods based on molecular biology opens a new zone of research reaction of central neurological system for trauma or ischemia with effort to get involved immediately at the beginning of developing adverse pathophysiological cascade leading to a death of neurotic cell. The brain contusion is a primary centre of brain injury with anatomic changes which can be graphically proved. In...

National Repository of Grey Literature : 125 records found   1 - 10nextend  jump to record:
See also: similar author names
2 NOVÁK, Zbyněk
21 NOVÁK, Zdeněk
21 Novák, Zdeněk
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