National Repository of Grey Literature 9 records found  Search took 0.00 seconds. 
HPLC-high resolution mass spectrometry analysis of in vitro and in vivo metabolism of scoparone
Novák, Filip ; Matoušková, Petra (advisor) ; Raisová Stuchlíková, Lucie (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences University of Eastern Finland in Kuopio, School of Pharmacy Department of Pharmaceutical Chemistry Candidate: Filip Novák Supervisor: Ing. Petra Matoušková, Ph.D. Consultant: prof. Seppo Auriola Title of Diploma thesis: HPLC-high resolution mass spectrometry analysis of in vitro and in vivo metabolism of scoparone Scoparone is an active ingredient of Artemisia scoparia, a medicinal plant used in traditional Chinese medicine. It has been studied for various pharmacological effects such as upregulation of conjugation enzymes included in excretion of bilirubin, reduction of proinflammatory cytokines, lowering of plasma lipids levels and inhibition of platelet aggregation. In this thesis, metabolism of scoparone was studied by LC-MS method using Q-ToF device. Scoparone was incubated with liver microsomes obtained from 6 different mammal species to study in vitro oxidation. In total, six metabolites were detected in the incubation samples. Scopoletin and isoscopoletin were identified as major metabolites in every species, however, the rates of scoparone oxidation as well as a ratio of formed isoscopoletin and scopoletin varied. Furthermore, in vivo metabolites in human were studied in urine samples obtained from...
HPLC-high resolution mass spectrometry analysis of in vitro and in vivo metabolism of scoparone
Novák, Filip ; Matoušková, Petra (advisor) ; Raisová Stuchlíková, Lucie (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences University of Eastern Finland in Kuopio, School of Pharmacy Department of Pharmaceutical Chemistry Candidate: Filip Novák Supervisor: Ing. Petra Matoušková, Ph.D. Consultant: prof. Seppo Auriola Title of Diploma thesis: HPLC-high resolution mass spectrometry analysis of in vitro and in vivo metabolism of scoparone Scoparone is an active ingredient of Artemisia scoparia, a medicinal plant used in traditional Chinese medicine. It has been studied for various pharmacological effects such as upregulation of conjugation enzymes included in excretion of bilirubin, reduction of proinflammatory cytokines, lowering of plasma lipids levels and inhibition of platelet aggregation. In this thesis, metabolism of scoparone was studied by LC-MS method using Q-ToF device. Scoparone was incubated with liver microsomes obtained from 6 different mammal species to study in vitro oxidation. In total, six metabolites were detected in the incubation samples. Scopoletin and isoscopoletin were identified as major metabolites in every species, however, the rates of scoparone oxidation as well as a ratio of formed isoscopoletin and scopoletin varied. Furthermore, in vivo metabolites in human were studied in urine samples obtained from...
Topical issues of the financial independence of the European Central Bank
Novák, Filip ; Tomášek, Michal (advisor) ; Vondráčková, Aneta (referee)
Topical issues of the financial independence of the European Central Bank The thesis aims to introduce the role of the European central bank during the financial crisis, including the legal aspects and risks related to conduct of non-standard measures of monetary policy, and to analyse concerned case law of the European court of Justice. Accordingly, this thesis attempts to point to the shortcomings and uncertainty of the interpretation of the primary law and to summarize the historic development of this legal issue. For this purpose the author draws on the historic context of the conduct of monetary policy of the European central bank and in particular on European court of Justice decisions. The thesis attempts to link the legal aspect with the economic aspect, which the author perceives as an essential attribute for a correct understanding of the whole issue. Key words: monetary policy, ECB, financial independence
Financial management of Týnec nad Sázavou Primary School
Novák, Filip ; Krbová, Jana (advisor) ; Jaegerová, Václava (referee)
This work deals with the financial analysis of the Týnec nad Sázavou Elementary School in order to find possible savings and new sources of financing. The thesis defines education in the Czech Republic. The education system and the main subjects of education are defined, especially the financing of basic education, followed by a concrete example of such funding, financing of the elementary school Týnec nad Sázavou. The thesis analyzes the financial management of this school, which seeks savings and new sources of financing.
Unification of the testing process in banking company
Cestr, Jan ; Pavlíčková, Jarmila (advisor) ; Novák, Filip (referee)
In the present, there are several programmes used for testing in this company. This may lead to a certain mutual inconsistency of the data within the system, as well as to the decrease of orientation and efficiency among the employees, that are in charge of the quality of the developed applications. There is approximately 200 employees in the IT department who focus on the development of the software. The biggest percentage has, though, the position of the tester. The aim of this thesis is to analyse the situation and the testing process in the selected bank company. Simultaneously, we would like to reach certain possibilities to unify the process of testing.
Implementation Document management system in Carpiness, s. r. o.
Novák, Filip ; Říhová, Zora (advisor) ; Svatá, Vlasta (referee)
Enterprise document management has been in a long-term progress. Not long ago only files and folders were enough for enterprise document management, but nowadays most of enterprise documents are in the electronic form. The electronisation of enterprise documents has carried simplified manipulation, but it has also caused disorderliness in many cases. Systems called Document managament system (DMS) bring support for better management of electronic enterprise documents. This diploma thesis deals with the implementation of DMS into the environment of a specific company where it is designed to support effective function concerning enterprise document management.
Analysis of Applications at the Municipality of Prague 6
Novák, Filip ; Benáčanová, Helena (advisor) ; Kratochvílová, Lenka (referee)
The aim of the thesis is to analyze selected applications at the Municipality of Prague 6. Basic municipality activities and applications related to them will be presented and evaluated. The main contribution of the thesis is the complex description of the selected applications and the presentation of their possible weaknesses and strong points.

See also: similar author names
1 Novák, F.A
21 Novák, František
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