National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Isolation and characterization of gangliosides recognized by Helicobacter pylori sialic acid binding adhesin SabA
Nguyen, Thuy Duong ; Kučerová, Marta (advisor) ; Kučera, Radim (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis University of Gothenburg Sahlgrenska Academy Institute of Biomedicine, Department of Medicinal Biochemistry and Cell Biology Student: Thuy Duong Nguyen Supervisors: PharmDr. Marta Kučerová, Ph.D. Prof. Susann Teneberg, MD PhD Title of diploma thesis: Isolation and characterization of gangliosides recognized by Helicobacter pylori sialic acid binding adhesin SabA Nowadays, Helicobacter pylori infection occurs in approximately 50% of mankind. It frequently causes gastric mucosal inflammation that may further lead to gastric and peptic ulcer disease and eventually result in gastric cancer. As it represents an important risk factor for gastric malignancies, it has been classified as carcinogen class I by IARC since 1994. Nevertheless, responses to the infection vary in either severity or extent due to diverse bacterial virulence. However, adhesion to the host's gastric mucosa plays a crucial role in successful colonization, thus understanding the mechanism and the role of adhesins have a great impact on treatment strategy. Therefore, our main aim included isolation and structural characterization of gangliosides recognized by H. pylori adhesin SabA. Firstly, the...
Isolation and characterization of gangliosides recognized by Helicobacter pylori sialic acid binding adhesin SabA
Nguyen, Thuy Duong ; Kučerová, Marta (advisor) ; Kučera, Radim (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis University of Gothenburg Sahlgrenska Academy Institute of Biomedicine, Department of Medicinal Biochemistry and Cell Biology Student: Thuy Duong Nguyen Supervisors: PharmDr. Marta Kučerová, Ph.D. Prof. Susann Teneberg, MD PhD Title of diploma thesis: Isolation and characterization of gangliosides recognized by Helicobacter pylori sialic acid binding adhesin SabA Nowadays, Helicobacter pylori infection occurs in approximately 50% of mankind. It frequently causes gastric mucosal inflammation that may further lead to gastric and peptic ulcer disease and eventually result in gastric cancer. As it represents an important risk factor for gastric malignancies, it has been classified as carcinogen class I by IARC since 1994. Nevertheless, responses to the infection vary in either severity or extent due to diverse bacterial virulence. However, adhesion to the host's gastric mucosa plays a crucial role in successful colonization, thus understanding the mechanism and the role of adhesins have a great impact on treatment strategy. Therefore, our main aim included isolation and structural characterization of gangliosides recognized by H. pylori adhesin SabA. Firstly, the...

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