|
|
The Influence of the Economic Crisis on Corporate Social Responsibility Activities
Potůčková, Petra ; Rynda, Ivan (advisor) ; Novák, Josef (referee)
The aim of this thesis is to introduce the concept of Corporate Social Responsibility (CSR) and describe the relevance of corporate social responsibility activities. Due to the fact that, one of the basic characteristics of Corporate Social Responsibility, is long-term in character, which requires a dedication to CSR activities, even in times of financial difficulties when company does not have the optimal results, this thesis shows how selected companies fulfill the concept of CSR. The theoretical part is divided into two parts - the first is the concept of Corporate Social Responsibility, which focuses on the development, pillars, benefits and concepts associated with this concept. I deal with crisis and describe financial crisis, economic crisis, its development, causes and consequences in the next part. The empirical part of this thesis is based on the methodological triangulation - expert interviews, documented examination and comparison. This thesis sampled five selected companies and shows how these companies perceive CSR, what activities they have implemented, how to cope with the crisis that affected them and how it affected the implementation of CSR activities. Another benefit of this thesis is to expand knowledge about values of companies around the city of Kolín. The results of this...
|
|
| |
|
|
Fish Rhabdoviruses and its prevention
Satoriová, Martina ; Drda Morávková, Alena (advisor) ; Novák, Josef (referee)
The rise of aquaculture has been one of the most significant changes in global food production over the last 100 years. Driven by rising demand for seafood, the growth of population, the farming of aquatic animals has expanded rapidly to become a major global industry. A number of aquatic animal species is kept in high densities in freshwater, brackish and marine systems where they are exposed to a new environment and potentially new diseases. On-farm stresses may negatively affect their ability to defeat infection. Impefect farming practices often facilitate fast transmission of disease. Viral pathogens, whether they have been known for decades or whether they are newly emerging, are particularly challenging since there are few, if any, efficacious treatments. The development of effective viral vaccines for delivery in aquatic systems still remains almost elusive. This thesis reviews a few of the more significant Rhabdoviral pathogens of finfish, their impacts, their prevention and the protective immune mechanisms that fish mount in response to rhabdovirus infections.
|
|
| |
|
|
Dissecting the nuclear function of the interleukin-1alpha
Novák, Josef ; Pospíšek, Martin (advisor) ; Vondrejs, Vladimír (referee)
Interleukin-1alpha (IL-1alpha) is a well-known proinflammatory mediator acting as a secreted molecule. However, in addition to its ability to activate its membrane-bound receptor, there is growing evidence on its noncanonical nuclear function, which classifies IL-1alpha as a "dual function cytokine". This nuclear action depends on the evolutionary conserved N-terminal domain of IL-1alpha. After proteolytic processing, the N-terminal domain of IL-1alpha translocates into nucleus. Histone acetyltransferase (HAT) complexes were previously identified as nuclear targets of IL-1alpha precursor. However, the specific protein which is responsible for the interaction between IL-1alpha and HAT complexes has not been identified yet. To dissect this interaction, the N-terminal domain of IL-1alpha was produced in yeast. Suitability of this experimental setup for testing the interaction between IL-1alpha and eukaryotic HAT complexes was evaluated in this study. IL-1alpha has been analyzed in this study using bioinformatics approaches as well. Putative amphipatic acidic helixes of IL-1alpha have been characterized. One of the potential binding partners of these domains is protein Ada2. Protein Ada2, mature IL-1alpha and IL-1alpha precursor in fusion with epitopes suitable for affinity purification were produced in...
|
|
| |
|
|
Study of the mammalian oncogenic transcription factors in the yeast model
Novák, Josef ; Šťovíček, Vratislav (referee) ; Zámostná, Blanka (advisor)
Yeast serves as a useful tool for studying cellular processes and therefore a large amount of techniques and protocols has been developed. There are special methods for studying the transcriptional factors in yeast, such as modified yeast two-hybrid screens, yeast one-hybrid screens and systems studying ability of transcription factors to transactivate a reporter gene. Oncogenes from AP-1 complex, Myc and Myb protein families are described in this work. Using a yeast model the structural-functional properties of proteins can be easily studied and in some cases even their ability of oncogenic transformation can be predicted (FASAY or ability of c-Myc to transactivate a reporter gene). However, results from yeast models must be confirmed in mammalian cells. 1
|
|
|
Perception of ecosystem services in an urban environment
Nožková, Markéta ; Vačkářová, Davina Elena (advisor) ; Novák, Josef (referee)
This thesis deals with city ecosystem services and how are these services perceived by the visitors of the city nature areas. Specifically, the thesis deals with ecosystem services provided in the city Carlsbad. As the city Carlsbad is the spa city, great deal of visitors of the city nature areas are tourists and that is why are included in the research both city residents and also temporary visitors of the city. From the point of view of the usual division of the ecosystem services, as it was defined by Millennium ecosystem assessment (provisioning services, regulating services, cultural and supporting services), this thesis focuses mainly on the cultural and supporting ecosystem services, because this spectrum of services is presented in the greatest measure in cities in general and these services are overall the most appreciated in the urban areas. As a methodology was chosen a quantitative research, which was conducted by standardized questionnaire consisting of 19 questions. The survey was carried out in electronical form and it took part from November to December 2016. In total, 206 questionnaires were collected. Through the survey was found out, that people are aware of the services provided by nature environment in city as well as the respondents agree, that city nature areas influence the...
|
|
|
Methods of Reliability Analyses of Operation and Testing Data of Airplanes
Novák, Josef ; Nevrlý, Josef (referee) ; Nejedlý, Ludvík (referee) ; Třetina, Karel (advisor)
The doctoral thesis deals with reliability (dependability) analyses of operation and testing data of the Airplanes. Requirements of airworthiness regulations on aircraft hydraulic systems (with a focus on US FAR-23 and European CS-23 regulations) are taken into account. Mentioned regulations include requirements for the structural design, design of systems, etc. They cover wide range of airplanes from small sport airplanes to 19-seats transport aircraft. Also options for predictive reliability analyses (resources) and reliability tests are discussed in the doctoral thesis. Practical application is done on small transport airplane (currently in the development). The failure report is designed. Expected major contribution of the work is selection and practical application of the most suitable procedures for safety assessment on the field of aircraft hydraulic systems, with a focus on the small transport aircraft. Also the comparison to different data source is shown.
|
|
|
Design of VUT200 TwinCobra landing gear
Novák, Josef ; Horák, Marek (referee) ; Katrňák, Tomáš (advisor)
The goal of following master thesis is to design variety of configuration and retraction options of VUT200 TwinCobra landing gear. For each option are a wheel base and a gauge set up by possibility of main landing gear retraction. Next, CS 23 demands and stress analysis are followed. There is a view of twin engine aircraft landing gear disclosed as well.
|
guest ::
RSS feed.