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Safety and Protection of Health during the Work of Professional Drivers
Chodurová, Zuzana ; Novák, Jaromír (referee) ; Adamec, Vladimír (advisor)
The theme of this bachelor thesis is Safety and Protection of Health during the Work of Professional Drivers. Given that most accidents at work in the Czech republic is in connection with vehicles, it is not surprising that safety and health at work is now becoming a priority for many employers. The aim thesis was to assess the risks arising from work performed by professional drivers and to suggest security measures to protect their health. The theoretical part explains the basic concepts and laws relating to the profession of professional drivers, a general description of the factors affecting the work environment and health and practicable methods for determining risks. The practical part of the work is focused on transport company called H.A.S. Ltd. The method of "what if analysis" is processed by the risk assessment and prevention and in cooperation with station regional hygiene is set categorization work. Part of thesis is questionnaire survey and recommendations for drivers, which are intended to minimize damage to health.
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Utilization of Financial Analysis as a Tool for Investment Decisions
Málek, Jiří ; Novák, Jaromír (referee) ; Ptáček, Roman (advisor)
This diploma thesis on the topic "Use of financial analysis as an instrument of investment decision-making" processes the financial evaluation of the economy and the effectiveness of selected investment decisions in the past years using methods of financial analysis. For this purpose, I chose the monitored period from 2012 to 2018. In the first part of the thesis, attention is paid to the evaluation of performance and financial sustainability in terms of implemented and planned investments of the theoretical base. The methods and analyzes used also include the methodology of their calculation. The second part deals with the individual indicators applied to Škoda Auto a.s., based in Mladá Boleslav a subsidiary of the Volkswagen Group. In addition, this section addresses the approach and decision making of the management of the company on investment projects that have already been planned or are planned in the near future, and recommendations are proposed for improving.
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Extreme situations solving in welfare institutions
Svoboda, Radek ; Valášek, Rudolf (referee) ; Novák, Jaromír (advisor)
This bachelor thesis deals with extraordinary events solving in social care institutions. There are introduced basic terms, case studies, legislative overview and legislative defined duties for building and operation of social care institutions in the Czech Republic. Next part contains definitions of extreme situations and description of its solving and possible complications. It was undertaken an analysis of the statistics in the Czech Republic about incidents during the last ten years. It contains description of recent state solution in nursing homes in district Pelhřimov. In the last parts are proposed amendments to regulations and standards.
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Measuring and Evaluating Company Performance Using Comparison between Companies
Novák, Jaromír ; Heralecký, Tomáš (referee) ; Kocmanová, Alena (advisor)
This bachelor’s thesis is aimed at the evaluation of the financial performance of the company FRAENKISCHE CZ s.r.o. and comparing it with the competitor LUNA PLAST a.s.The comparsion between these two companies is made in the period from 2018 to 2020 and then the improvement proposal is submitted. The work is divided into three parts. In the first one, theoretical, are defined concepts and the indicators of financial analysis. In the analytical part, values were calculated by using individuals indicators which were mentioned in the previous part. The final part presents the recommendations for improvement of the financial situation of the company.
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Measuring and Evaluating Company Performance Using Comparison between Companies
Novák, Jaromír ; Heralecký, Tomáš (referee) ; Kocmanová, Alena (advisor)
This bachelor’s thesis is aimed at the evaluation of the financial performance of the company FRAENKISCHE CZ s.r.o. and comparing it with the competitor LUNA PLAST a.s.The comparsion between these two companies is made in the period from 2018 to 2020 and then the improvement proposal is submitted. The work is divided into three parts. In the first one, theoretical, are defined concepts and the indicators of financial analysis. In the analytical part, values were calculated by using individuals indicators which were mentioned in the previous part. The final part presents the recommendations for improvement of the financial situation of the company.
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Methods of murine brain 3D imaging focusing on tissue clearing
Novák, Jaromír ; Drbal, Karel (advisor) ; Němec, Pavel (referee)
1 ABSTRACT Many variants of microscopic techniques are the key methods for tissue structure examination in the research as well as in clinical practice. Since the vast majority of examined tissues are intrinsically opaque, it is difficult to reconstruct their 3D structure with light microscopy. However the spatial structure is inherently connected to the function of cells, tissues or whole organs. The most common approach is sample sectioning to the thin layers, which are subsequently examined or used for 3D structure reconstruction of the sample. A different approach is to use a series of chemical reagents able to clear the samples and make them accessible for imaging via microscopy without the need for physical sectioning. Although this approach was first used more than a century ago, the widespread use of these methods came in the last few years. Since the resurgence of tissue clearing method a lot of new principles how to clear the samples were discovered as well as many new chemical compounds can be used for this purpose.. Clearing methods are becoming more and more sophisticated: the volume of samples which can be cleared is continuously growing, new methods are becoming faster and automated, the quality of after-cleared tissues is improving and compatibility with many stains including antibodies is...
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Immunoscore in 3D tissue
Novák, Jaromír ; Drbal, Karel (advisor) ; Procházka, Jan (referee)
Solid tumors are complex structures comprising besides the cancer cells vasculature, extracellular matrix (ECM), soluble molecules and a plethora of various other cell types. These components form a so-called tumour microenvironment. From the numerous cell types that are part of tumor microenvironment, tumor infiltrating lymphocytes (TILs) play a major role in patient prognosis. Their presence is also of major importance with regard to new biological therapies based on immune checkpoint inhibitors. Crucial role of TILs is also reflected by the new approaches in cancer diagnostics namely by Immunoscore method (currently used in clinical settings). Immunoscore is based on localization and quantification of CD3+ and CD8+ TILs in thin histological sections of tumor tissue. The question remains to which extent the information obtained from 2D slices reflects the situation in tumor microenvironment considering its spatial heterogeneity. The development of new methodological approaches allowing evaluation of histological information in 3D is the key to answer this question. The theoretical part of this work first describes the heterogeneity of the tumor microenvironment and the role of immune cells within it. Then, the role of spatial heterogeneity and its possible influence on the histopathological...
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