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Reunified description of acid-base physiology and chemistry of blood plasma
Matoušek, Stanislav ; Kofránek, Jiří (advisor) ; Wooten, Wrenn (referee) ; Kittnar, Otomar (referee)
This thesis addresses an important problem of biomedical acid-base theory, where there are two apparently contradictory ways of describing the acid-base status of blood plasma, while the underlying physiology and chemistry obviously has to be only one. The two descriptions are called the traditional approach, based mainly on the work of Ole Siggaard-Andersen and the modern approach, based on the work of Peter Stewart and his followers. This work has three starting points. First are generally accepted basic concepts of acid-base chemistry and physiology. Second is an elegant formalism to the description of acid-base phenomena in complex solutions developed by Guenther. First part of this thesis builds on these two starting points, which serve as a basis for a detailed analysis augmented by the use of simple computer modelling. This results in formal description of several more advanced concepts, including the titration curves of proteins, behaviour of bicarbonate and protein buffers in single solution, relationship between strong ion charge and protein buffer charge and fuzzy division between strong ions and buffer ions in physiology. The modeling work then proceeds to comparing various models of albumin, principal protein buffer of blood plasma. Theoretical concepts of this work, such as pH-pKA...
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