National Repository of Grey Literature 150 records found  beginprevious99 - 108nextend  jump to record: Search took 0.00 seconds. 
Early diagnostic of mnestic disorders in neurodegenerative diseases
Laczó, Jan ; Bojar, Martin (advisor) ; Jirák, Roman (referee) ; Mareš, Jan (referee) ; Rektorová, Irena (referee)
The ageing of the world's population means that the number of people with dementia, especially Alzheimer's disease (AD), will dramatically increase. That's why there is now a great effort to detect the presence of AD in its earliest predementia stages, in the stage of mild cognitive impairment (MCI), and particularly to identify individuals with amnestic syndrome of the hippocampal type (Ha-MCI - preclinical AD). The aim of our studies was to reveal whether spatial navigation testing could serve as an early biomarker of AD - whether spatial navigation is impaired early in patients with MCI, especially in Ha-MCI patients. We used the human analogue of the Morris water maze, the Hidden Goal Task (HGT), which is designed t! o separate two different modes of navigation, egocentric (body- centred, hippocampus independent) and allocentric (world-centred, hippocampus dependent), using a real space navigation setting called the Blue Velvet Arena (BVA), fully enclosed cylindrical arena, as well as a computer version of the BVA. Our results suggest that spatial navigation is impaired already in patients with amnestic MCI, who are more likely to progress to AD, especially in those with amnestic syndrome of the hippocampal type. The Ha-MCI patients presented severe spatial navigation impairment similar to that seen in...
The Human Nature and Natural Morality in Francis Fukuyama
Mareš, Jan ; Hošek, Pavel (referee) ; Halama, Jindřich (advisor)
The bachelor thesis focuses on a survey of concepts of human nature at the end of 20th century, specifically in the works of Francis Fukuyama. The introductory part descibes general contemporary situation and background. The main part deals with the formation of different natural aspects of human behavior from the perspective of sociobiology such as cooperation, intelligernce, language and morality the way F. Fukuyama interpretes them. It tries to expound how these aspects were formed during the long evolutionary development. Understanding these mechanisms should help us comprehend why there are natural tendencies to bahave the way we do. It also searches boundaries between human nature and cultural environment. The final part answers some key questions this topic evokes. Powered by TCPDF (www.tcpdf.org)
The use of physiological and pathophysiological pressure ratios in the area of the biliary ductal system and pancreas for diagnosis and treatment by endoscopic retrograde cholangiopancreatography
Keil, Radan ; Kvapil, Milan (advisor) ; Frič, Přemysl (referee) ; Hep, Aleš (referee) ; Mareš, Jan (referee)
:.In our work we wanted to confirm our clinical experience with therapy of biliary and pancreatic duct injuries from the endoscopic retrograde cholangiopancreatography (ERCP) which was done in 267. Children and infants with a variety of biliary tract disorders and traumatic injuries in the area of biliary and pancreatic duct.. Pressure of the bile plays the key role in the therapy of biliary tract injuries Therefore we have measured the pressure in biliary tract and duodenum before and after the sphincterotomy of Oddi sphincter. Thea aim of our study was to confirm the insertion of drainage into the biliary and pancreatic duct in children with injury in this area. Our results showed significant differences between biliary duct pressure and duodenal pressure in the patients before and after sphincterotomy of Oddi sphincter. This results on theoretical basis confirmed, that it is necessary in children after traumatic rupture of biliary duct to provide ERCP and insert a biliary drainage after sphincterotomy. With this procedure the biliary tract injury is healed ad integrum without surgical liver resection. To provide only papilosphincterotomy without biliary drainage is not sufficient. This new miniinvasive procedure plays a fundamental role in the therapy of blunt abdominal injuries in a children and infants...
Vascular Calcification and Bone Demineralization in Patiens with Chronic Renal Failure
Mareš, Jan ; Opatrná, Sylvie (advisor) ; Topolčan, Ondřej (referee) ; Spustová, Viera (referee) ; Štěpán, Jan (referee)
Background: Patients treated with chronic dialysis show extreme mortality, particularly due to cardiovascular disease. Renal failure is associated with different risk factors of cardiovascular complications than those defined for non-renal population. One of these factors, currently considered most important, are vascular calcifications. At the same time, patients on dialysis regularly suffer from derrangements of calcium-phosphate metabolism, including skeletal demineralization. As a consequence, both incidence and prevalence of bone fractures are high. Aims: This study therefore investigates vascular calcifications and skeletal demineralization, their clinical implications and associations in patients treated with long-term dialysis. Methods: Two groups of patients were examined in a prospective manner (follow-up > 1 year); 32 patients treated with peritoneal dialysis and 72 treated with regular hemdodialysis. Treatment parameters and biochemical markers of calcium-phosphate metabolism were monitored throughout the study. Bone mineral density of lumbar spine (together with vertebral fractures) as well as coronary artery, valvular and aortic calcifcations were determined repeatedly. All radiological parameters were measured during one computed-tomography scanning session. Results: A significant...
The Magdeburg law in the towns of northwest Bohemia in pre-Hussite period
Mareš, Jan ; Žemlička, Josef (advisor) ; Bobková, Lenka (referee) ; Sulitková, Ludmila (referee)
The beginnings and propagation of the Magdeburg Law in the Czech lands in the Middle Ages are in the centre of attention of historical sciences since the second half of the 19th century. The period of great interest in this theme ends in the middle of the last cen tury and there i s a change in the direction of conservation of older knowledge. A detailed look on notorious development trends in connection with use of different types of sources can open new possibilities for efforts concerning deeper cognition of one of the most important components of the so called medieval transformation. The Magdeburg Law is a phenomenon transgressing borders of contemporary as well as medieval states in Centra!- and Eastern Europe, which is the reason to study it in the context of wider regions. Presented study incorporates three themes. The first chapter is dedicated to the analysis of the initial situation that existed in the thirteenth century in one of the most important cities of northwest Bohemia Litoměřice, the later head of a great family of cities of German town law. The starting point for an attempt to explore the Litoměřice law in the 13th century is a not preserved compilation of various legal regulations sent directly from Magdeburg to Litoměřice in 1282. This is a rare case in Czech lands, which could be...
Animal models of psychosis - the assessment of EEG and the levels of monoamines in the CNS of the rat
Lipski, Michaela ; Horáček, Jiří (advisor) ; Šulcová, Alexandra (referee) ; Mareš, Jan (referee)
The present work describes animal models of psychosis with the aim on monoamine levels and behavioral/EEG findings. The general part is focused on reporting biochemical and EEG findings in patients with schizophrenia, followed by animal models of schizophrenia and their EEG findings. In the special part, results of behavioral and EEG parameters in three animal models of psychosis are presented. A study by Palenicek et al, 2013 described serotoninergic animal model and showed that 4-bromo-2,5-dimetoxyfenyletylaminu (2C-B) induced deficit in prepulse inhibition of startle reaction and produced dose related biphasic changes in the locomotion (i.e. hypolocomotion was followed by the hyperlocomotion). Low doses of 2C-B decreased EEG power and coherence, while high doses had a temporary biphasic effect with an initial decline followed by an increase in power - a similar effect was also observed in the coherence. In microdialysis study, increased levels of dopamine and its metabolites homovanilic acid and 3-methoxytyramine and decreased levels of 3,4-dihydroxyphenylacetic acid in the nucleus accumbens are described. The increase in the EEG power and coherence after the 2C-B application was associated with an increase in locomotion and congruently with elevated dopamine levels in the nucleus accumbens....
Consequences of early ischemic hippocampal lesion in rats
Mátéffyová, Adela ; Kubová, Hana (advisor) ; Mareš, Jan (referee) ; Brázdil, Milan (referee) ; Kozler, Petr (referee)
Stroke is an important cause of neurological morbidity in infants and children, with an incidence of approximately 8 cases per 100000 per year (Giroud et af. 1995). In chi ldren, stroke is often under-recognized/unrecognized because of variation in the presentation, evaluation, and diagnosis. In many cases, asyrnmetry of reaching and grasping, failure to reach developmental milestones, or post-neonatal seizures that appear some months after the acute event are the only mark of previous stroke. Powered by TCPDF (www.tcpdf.org)
The motor and cognitive consequences of inborn cerebellar degeneration and some possibilities how to influence it
Křížková, Alena ; Vožeh, František (advisor) ; Pokorný, Jaroslav (referee) ; Mareš, Jan (referee)
The motor and cognitive consequences of inborn cerebellar degeneration and some possibilities how to influence it The cerebellum is traditionally considered to be a coordinator of movements and equilibrium and a regulator of muscular tone. Participation of the cerebellum on the motor learning has been discovered later. Besides that, there is increasing experimental and clinical evidence supporting the idea of an important role of the cerebellum in common cognitive functions. Increasing number of experimental works - especially those on animals - demonstrate an effect of the the cerebellum on the memory and different types of learning. A suitable model to study the cerebellar degeneration are Lurcher mutant mice. During their lives, there is a progressive loss of Purkinje cells followed by a loss of granular cells and inferior oliva neurons. We concentrated on the following problems in this work: - development of motor learning and topical motor skills during the first month of life - positive and negative changes in NO synthesis and subsequent effect on discriminative learning - effect of administration of MK-801(non-competitive antagonist of NMDA receptors) on discriminative learning of Lurcher mutants and wild mice derived from two strains (C3H and C57B1/7). Lurcher mutants and wild mice were put in motor...
název v anglickém jazyce není uveden
Štulc, Tomáš ; Češka, Richard (advisor) ; Vaverková, Helena (referee) ; Mareš, Jan (referee)
Lipid lowering treatment substantially reduces the risk of cardiovascular diseases. The effects of lipid lowering go far beyond limiting the extent of atheroslcerotic lesions and decreasing the severity of atherosclerotic stenoses. Recently recognised effects of cholesterol on plaque stability, endothelial function, thrombosis, and plaque inflammation have been subject to intensive research during the past two decades. The effect lipid lowering treatment on the various aspects of the plaque development are being investigated in search of novel therapies to reduce the risk of ahterosclerosis. In this work, we examined cell adhesion molecules, microvascular reactivity and metalloproteinase PAPP-A in patients with hypercholesterolemia and investigated the effect of lipid lowering with atorvastatin and LDL-apheresis. Leukocyte and endothelial adhesion molecules mediate leukocyte recruitment into subendothelial space, contributing thus to plaque inflammation. PAPP-A is a protease which has been related to plaque instability and acute coronary events; it's role in stable atherosclerotic lesions hasn't been studied yet Microvascular reactivity is supposed to reflect endothelial function in the microvascular bed; the knowledge of the effect of hyperlipidemia on microvasculature is currently limited. Patients with...

National Repository of Grey Literature : 150 records found   beginprevious99 - 108nextend  jump to record:
See also: similar author names
46 MAREŠ, Jan
20 MAREŠ, Jiří
6 MAREŠ, Josef
2 Mareš, J.
15 Mareš, Jakub
7 Mareš, Jaroslav
1 Mareš, Jindřich
20 Mareš, Jiří
1 Mareš, Jiří A.
1 Mareš, Jiří J.
6 Mareš, Josef
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