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Computational modelling of self-excited oscillation during metal cutting
Malý, Pavel ; Hadaš, Zdeněk (referee) ; Švancara, Pavel (advisor)
Diplomová práce se zabývá analýzou produktivity a efektivity řezného procesu frézování. Pro zjištění kritické hloubky třísky byla analyzována reálná frézka. Model frézky byl vytvořen v programu Autodesk Inventor. Analýza řezného procesu probíhala v programu Ansys Workbench. Výsledky byly použity pro sestavení stabilitních diagramů. Po vyhodnocení výsledků byly navrženy dva přístupy pro zefektivnění procesu frézování. Vliv těchto změn na produktivitu řezného procesu byl ověřen porovnáním výsledků s předchozí analýzou.
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Design of Automatic Trading Systém Based on Fractal Geometry
Malý, Petr ; Dostál, Petr (referee) ; Budík, Jan (advisor)
This thesis deals with an analysis and prediction of foreign exchange markets. The thesis is based on the fractal market hypothesis and it uses tools based on fractal geometry for prediction of markets. The thesis also describes ways of using advanced methods of artificial intelligence for analyzing markets. The outcome is designed and implemented automatic trading system. The thesis also deals with testing of designed system on historical data and on the latest data as well.
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Mobile Cash Desk
Malý, Petr ; Hruška, Tomáš (referee) ; Kurečka, Radomír (advisor)
The bachelor thesis deals with the proposition and the implementation of system for mobile orders in restaurants, that would enable sta ff to create and to bill orders. Spending can be paid from customer's account after customer authentication. The system is implemented for mobile platform Windows Phone version 7.5.
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Control system for temperature stabilization
Malý, Pavel ; Běťák, Petr (referee) ; Kadlec, Jaroslav (advisor)
This bachelor´s thesis is engaged in problems, programming and proposal of Control system for temperature stabilization of any system. Main condition is using the Peltier´s component and microcontroller. Principle consists in setting of temperatures by user controls and operating of Peltier´s component thought MOSFET semiconductors. This MOSFET´s are designed to an H-bridge. We regulate power of Peltier´s component by the H-bridge. Main part of the circuit is microcontroller from ATMEL. This is called ATmega16. It’s programmed by ISP (In System Programming) property of microcontroller, which is necessary for programming of microcontrollers in applications. All measured and controlled values will be showed on the LCD display and should by supply by the 5V power source.
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Preparation of mutant variants of Kingella kingae RtxA cytotoxin for membrane topology research
Lichvárová, Michaela ; Osičková, Adriana (advisor) ; Malý, Petr (referee)
Kingella kingae is a facultative anaerobic, β-hemolytic, gram-negative bacterium. It has been shown, that K. kingae is an important cause of invasive infections in young children, especially between 6 to 36 months of age. The most common diseases caused by K. kingae are septic arthritis, osteomyelitis, bacteremia and infective endocarditis. The key virulence factor of K. kingae is the secreted RtxA toxin, which belongs to the RTX toxins family (Repeats in ToXin). These are divided into two categories, hemolysins and leukotoxins, based on the cellular specificity of their action. The broad specificity of the RtxA toxin indicates that RtxA can be classified as a cytolytic RTX hemolysin. RtxA molecules are inserted into the host cell membrane and form cation-selective membrane pores that trigger cation flux. This disrupts normal cell physiology and eventually leads to cell lysis. The aim of this bachelor thesis was to prepare mutant variants of the K. kingae RtxA cytotoxin with lysine substitutions in the pore-forming domain for future study of the membrane topology of the toxin using biotin binding to the lysine residues. In order to observe the topology of the RtxA toxin in the host cell membrane, the toxin must be able to insert to the cell membrane. Therefore, another objective was to determine...
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Properties of color centers in diamond studied by methods of femtosecond laser spectroscopy
Streshkova, Neli ; Malý, Petr (advisor) ; Dzurňák, Branislav (referee)
In this work, we focus on the interaction of SiV color centers in diamond with femtose- cond light pulses. In the theoretical part, a script is developed to simulate the experimen- tal varying stripe length method and the effects of saturated optical gain are investigated. In the experimental part, photoluminescence and transient differential absorption under non-resonant excitation are studied. The result of the luminescence measurements are estimates of the effective cross-sections of single-photon absorption for the wavelengths 620 nm, 515 nm and 340 nm, as well as the effective cross-section of three-photon absorp- tion for 2000 nm. The result of the differential absorption measurements is the relaxation constant of the excited level of the SiV center and the upper estimate of the time duration of the initial dynamics. 1
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Current approaches in the development of vaccines against infectious viral diseases
Vargová, Soňa ; Malý, Petr (advisor) ; Osička, Radim (referee)
Vaccination remains one of the most successful biomedical interventions for preventing viral diseases. While early vaccines were developed by attenuating the infectious agent in cell cultures or by inactivation, new delivery platforms are on the rise thanks to the advent of genetic engineering. The COVID-19 pandemic stimulated the rapid adoption and a massive deployment of these platforms. Viral vector vaccines elicit antigen expression within cells and induce a robust cytotoxic T cell response, unlike protein subunit vaccines conferring mainly humoral immunity. mRNA vaccines also deliver the antigen inside the cells while offering more manageable and faster manufacturing possibilities. Unlike DNA-based vaccines, mRNA does not enter the nucleus, and thus, the probability of disrupting gene expression in the recipient cell is diminished. This thesis aims to offer an overview of current approaches in vaccinology and discuss the various platforms in use. The thesis will also present recent advances in the development of prophylactic vaccines against infections with human immunodeficiency virus-1 (HIV-1) and hepatitis C virus (HCV) and also will focus on a recently proposed strategy for vaccine development based on non-cognate ligands mimicking epitopes recognised by broadly neutralising antibodies...
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