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Measuring adherence in patients with oral targeted therapy in chronic lymphocytic leukaemia
Hanusová, Barbora ; Malý, Josef (advisor) ; Kolmanová, Eliška (referee)
Measuring adherence in patients with oral targeted therapy in chronic lymphocytic leukaemia Author: Barbora Hanusová Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Petra Rozsívalová Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Chronic lymphocytic leukaemia (CLL) is a hematological disorder characterized by clonal proliferation of mature B-cells. New oral targeted drugs have been used in clinical practice to treat CLL. The aim of this thesis was to measure adherence to oral targeted drugs, analyze pharmacotherapy and identify drug-related problems (DRP) and their management. Methods: The cross-sectional pilot study ran from September 2022 to March 2023 in University Hospital Hradec Králové. Patients ≥ 18 years old, with CLL diagnosis treated with ibrutinib, acalabrutinib or venetoclax were included. Medical data and pharmacotherapy were obtained using electronic medical records and patients' medication records. Guided interviews were performed to measure patients' adherence to oral targeted oncolytics using Czech version of The Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS-CZ) and determine their opinions about medicine using Czech translation of The Beliefs about Medicines...
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Analysis of drug administration by nurses in health facility XII
Gröszlová, Anna ; Doseděl, Martin (advisor) ; Malý, Josef (referee)
ANALYSIS OF DRUG ADMINISTRATION BY NURSES IN HEALTH FACILITY XII Author: Anna Gröszlová Supervisor of the thesis: PharmDr. Martin Doseděl, Ph.D. Charles University, Faculty of Pharmacy in Hradec Králové, Department of Social and Clinical Pharmacy Introduction: Medication administration in healthcare facilities significantly affects patient's safety. Observing and analyzing this process provide information about medication administration errors and the factors influencing them. As a result of observational findings, we can create interventions to improve the administration process. Aim: The aim of this work was to describe and analyze medication administration errors in a healthcare facility. Methods: The direct observation method was used for observation. Data collection took place in three departments (surgery, neurology, follow-up care) in 2021 and 2022. In both years, collection took place in each department on 3 consecutive days. Morning, midday and evening medication administration was monitored. An electronic database was used for recording. Data evaluation was done in Microsoft Excel and data from 2021 and 2022 were analyzed together. Nurse's work practices and medication errors were evaluated. Results: In total, 1160 drug administrations to 114 patients were observed. The largest number of...
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Analysis of drug utilization of antibiotics for systematic administration in the Czech Republic in 2005-2019
Suchopárová, Lenka ; Malý, Josef (advisor) ; Kolář, Jozef (referee)
Analysis of drug utilization of antibiotics for systematic administration in the Czech Republic in 2005-2019 Author: Lenka Suchopárová Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: Mgr. Petr Domecký Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles university Introduction and aims: Antibiotics (ATB) are substances with a bacteriostatic or bactericidal effect. Treatment with ATB carries a risk of side effects, drug interactions and risk of resistance occurence. The reason for monitoring the consumption of ATB is not only the apparent coherence between their consumption and the increase of resistance, but also the economic side of bacterial infections treatment. The aim of this study was to analyze the consumption of ATB for systematic administration in the Czech Republic (CR) in 2005-2019. Methods: The analysis of the consumption of ATB was performed as a retrospective analysis of data from the database of the State Institute of Drug Control in the period from 1. 1. 2005 to 31. 12. 2019. Anatomical-therapeutic-chemical classification based on defined daily doses (DDD) of individual drugs was used for the analysis. The consumption of ATB was calculated as DDD per thousand inhabitants per day (TID). The data on the number of residents was acquired from the...
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Analysis of pharmacotherapy in patients in the hospice
Sládek, Jakub ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Analysis of pharmacoterapy hospice care patients Author: Jakub Sládek Tutor: doc. PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and purpose: The therapy of hospice care patients is accompanied by many changes and pitfalls that need to be balanced when choosing appropriate therapy. In the teoretic part we can find available information about paliative therapy of hospice care patients, with emhasis on pain therapy. The aim of this thesis is the analysis of pharmacotherapy hospice care patients. Methods: The data were collected in a hospice from September 2019 to November 2019. The farmacotherapy was revised every first day of the month. Informations from personal, drug, family and occupational social history of patients were noted into an electronic database and, after revision, were classified and evaluated by frequency analysis. In four randomly selected patients was described the management of drug-related problems (DRP). Results: In total we noted medical therapy in 40 patients, women were 75 % of this number. Average patient's age was 72.4 years for men and 74.6 for women. Patients most often used drugs from group N (drugs of the nervous system) according to the ATC classification. We indentified 115...
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Analysis of drug administration by nurses in health facility III
Novosadová, Aneta ; Malý, Josef (advisor) ; Šorf, Aleš (referee)
1 Abstract Analysis of drug administration by nurses in a health facility III Author: Aneta Novosadová Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: Mgr. Ondřej Tesař Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: The drug administration by nurses is one of the most important part of a nursing care performed on daily basis. The goal of this master's thesis was to analyze the drug administration by nurses to the patients hospitalized in the internal, surgical or aftercare wards in one of four health facilities in the South Bohemian region with an emphasis on medication errors and their prevention. Methods: This is a part of an extensive observational and intervention study, which is conducted between years 2020-2023. The thesis demonstrates the data acquired by a direct observation of drug administration to the hospitalized patients from 19th to 25th July 2021. The data were collected by teams composed by a pharmacist and a nurse. The collected data were as follow: patients' personal data (e.g., age, gender, list of all drugs used by patient), data about the nurse who administered drugs (age, gender, length of working experience), data of the drug administration (the way of identification of the patient; the nurse's hygiene...
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Analysis of drug utilization of antidiabetics
Dvořáková, Nelly ; Malý, Josef (advisor) ; Doseděl, Martin (referee)
Analysis of drug utilization of antidiabetics Author: Nelly Dvořáková Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Simona Dvořáčková, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and objective: Effects of antidiabetics prevent serious consequences on mortality, morbidity and quality of life of patients. The objective of practical part of this thesis was to analyze trends of antidiabetics utilization in the Czech Republic between 2005−2021. Methods: The utilization of antidiabetics was analysed in the period from 1st January 2005 to 31st December 2021. The data were obtained from the State Institute for Drug Control database, where are collected reports from distributors regarding the supplies to healthcare institutions including pharmacies, vendors of selected pharmaceuticals and veterinarians. The denominator was number of inhabitants in Czech Republic in particular years in study period. The drug utilization of antidiabetics in Defined Daily Doses (DDD) was converted to Defined Daily Dose/1000 inhabitants/day (DID). The values of DDD of medicaments in fixed combinations were also converted to DID but not converted to their single components. The descriptive statistics was used to analyze the data. Results:...
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Analysis of drug administration by nurses in health facility I
Sládková, Zuzana ; Malý, Josef (advisor) ; Šorf, Aleš (referee)
Analysis of drug administration by nurses in a health facility I Author: Zuzana Sládková Tutor: doc. PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Drug administration is one of the riskiest part of nursing. The aim of this thesis was to analyze the drug administration by nurses to the patients hospitalized in four hospitals in the South Bohemian region. Methods: The data for this observational-interventional study were collected from June to August 2021 in four hospitals (surgical department, internal medicine department, aftercare department), during three consecutive days in each department.The data were collected by a trained team consisting of a pharmacist and a nurse using direct observation. The following parameters were observed: information about the patient (e.g. gender, age, pharmacotherapy), information about the nurse (e.g. gender, education, length of practice), data related to drug administration (e.g. hygiene, patient identification, the right drug, the right patient, the right strength, the right dose, the right time, handling the medicine, the drink used to take the drug, drug administration in relation to food). The data were anonymized, transferred into the web database and...
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Self-medication of patients using immunosuppressants
Zouharová, Veronika ; Malý, Josef (advisor) ; Babica, Jan (referee)
Self-medication of patients using immunosuppressive drugs Author: Veronika Zouharová Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Barbora Košťálová, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy, in Hradec Králové, Charles University Introduction and aims: Self-medication can be used to treat minor health problems without consulting a doctor. The aim of this masters thesis was to analyse the use of potentially risky over- the-counter medicines, dietary supplements or food in patients with a history of kidney disease taking immunosuppressants. Methods: Data for the cross-sectional study were obtained in the form of a controlled interview with patients of the Nephrology Consultation of the Teaching Hospital Hradec Králové. The guided interview was carried out by the researcher in the form of phone calls with patients in March 2022 through a structured questionnaire. The questionnaire was compiled on basis of a literature search and knowledge gained about possible interactions between immunosuppressants and over-the- counter medicinal products, dietary supplements and food. Patients with kidney disease who had been taking at least one immunosuppressant (cyclosporine, azathioprine, mycophenolate, prednisone, tacrolimus or rituximab) for past six months were...
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Vaccination and pharmaceutical care I
Žižková, Tereza ; Malý, Josef (advisor) ; Hendrychová, Tereza (referee)
Vaccination and pharmaceutical care I Author: Tereza Žižková Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Eliška Kolmanová, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aim of study: Vaccination can be considered an effective tool for the prevention of infectious diseases. Its main importance lies in the protection of the entire population. The aim of this thesis was to analyze the attitudes and opinions of patients regarding the possibility of vaccination against influenza in pharmacies in the Czech Republic (CZ). Methods: The research consists of the answers of 2032 citizens of the CZ over the age of 15, randomly selected by the technique of the standardized quided interview. They were approached between 16. 11. 2020 and 20. 12. 2020 with a request for comments on the issue of healthcare and the healthy lifestyle of the population. Part of this survey were questions about the issue of vaccination against influenza. Respondents were asked 21 closed, semi-closed and open-ended questions focused on socio-demographic characteristics, attitudes and opinions of respondents on influenza vaccination, including the possibility of vaccination in a pharmacy. Data were evaluated with descriptive statistics and...
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Analysis of the possibilities of influencing antibiotic prophylaxis in orthopedics on the basis of inflammatory markers
Preiss, Přemysl ; Malý, Josef (advisor) ; Doseděl, Martin (referee)
Analysis of the possibilities of influencing antibiotic prophylaxis in orthopedics on the basis of inflammatory markers Author: Přemysl Preiss Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Petr Domecký Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aim: Endoprosthetic surgeries are demanding orthopedic surgeries rarely associated with complications, that can be fatal. One is periprosthetic joint infection (PJI), whose risk can be decreased by antibiotic prophylaxis (AP). The aim of this effort was to describe trends in endoprosthetic surgeries of the knee and the hip, their complications and options of diagnostics in the theoretical part. The aim of the practical part was to analyze prognostic features of chosen laboratory parameters on postoperative infections, respectively on postoperative complications. Methods: This prospective study started in March 2020 and data gathering took place until 28. 3. 2022 at the Ortopedic Clinic of the University Hospital Hradec Králové. Patients, who were included in the study, fulfilled the preliminary criteria, e.g. age ≥ 18 years, patient undergoing total hip or knee arthroplasty at the time of the study and giving the informed consent to the study. Data were gathered from...
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