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Drug Information Centre service analysis III.
Harazimová, Tereza ; Malá, Kateřina (advisor) ; Matoulková, Petra (referee)
Drug Information Centre service analysis III. Author: Tereza Harazimová Supervisor: PharmDr. Kateřina Malá, Ph.D. Consultant: PharmDr. Petra Rozsívalová Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction: Drug Information Center (DIC) of the Faculty of Pharmacy in Hradec Králové, Charles University, and University Hospital Hradec Králové was established in 1994. Major activity of the DIC is providing expert information about drugs - primarily in the form of answers to various medicines-related enquiries sent by healthcare professionals. DIC deals with enquiries related to general pharmacotherapy including complementary and alternative medicine (CAM). Aim of study: Aim of the study was to evaluate DIC's activity in the period 2015-2017 through feedback from questioners and to analyse enquiries related to CAM in the period 1994-2017. Methods: The feedback of questioners whosent the enquiry to DIC from 2015 to 2017 was obtained using an online questionnaire containing 18 items - sociodemographic data and awareness of DIC, quality of answers to enquiries, satisfaction with provided services and lastly resolving of CAM related issues in practice. Furthermore, analysis of DIC's database in the period 1994-2017 was performed....
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Insurance pricing methods based on risk measures
Malá, Kateřina ; Branda, Martin (advisor) ; Mazurová, Lucie (referee)
In this thesis we study various risk measures and one of their characteristics - the coherence. We talk especially about value-at-risk (VaR in short), respectively about conditional value-at- risk (CVaR). We also mention the advantage of CVaR against VaR. After that we discuss the most common forms of compound distribution that are used in practice. The final part of this bachelor thesis is dedicated to a numerical study where we calculate mean, variance, VaR a CVaR for specific values of parameters.
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Attitudes towards treatment and knowledge of hormonal contraceptive users
Fufaľová, Veronika ; Malá, Kateřina (advisor) ; Matoulková, Petra (referee)
Diplomová práca Postoje k liečbe a znalosti užívateliek hormonálnej antikoncepcie Abstract Attitudes towards treatment and knowledge of hormonal contraceptive users Author: Veronika Fufaľová¹ Supervisor: PharmDr. Kateřina Ládová, Ph.D.¹ Consultant: PharmDr. Anna Oleárová, PhD., MPHš ¹Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic šDepartment of Organisation and Management of Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Slovak Republic Introduction: Hormonal contraception (HC) is popular and a reliable birth control method. Its use is although associated with some risks and many myths or misconceptions. Objective: The aim of this thesis was to determine the attitudes towards treatment and awareness of HC risks of its users in regard to various types and application forms in specific region by means of anonymous questionnaire. Methods: The research was carried out as a prospective questionnaire survey. Anonymous questionnaires consisted of 35 questions divided into 6 sections to obtain sociodemographic data, information concerning HC users and their form of HC, information about the extent of knowledge concerning gynaecological examination, HC risks and HC misconception awareness. One part of questionnaire was focused...
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Analysis of drug-related problems in outpatients II.
Sperottová, Šárka ; Doseděl, Martin (advisor) ; Malá, Kateřina (referee)
Analysis of drug-related problems in general practitioners office II. Author: Šárka Sperottová Supervisor of the thesis: PharmDr. Martin Doseděl, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Background: A Drug-Related Problem - DRP - is according to Pharmaceutical Care Network Europe - PCNE - an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes. We can encounter DRP in every general practitioner's - GPs - office all around the world. But with proper cooperation between practitioners and pharmacists we could reduce the number of problems. That would be big benefit for patients and health system as well. This thesis is focused on anticoagulant drugs, mainly on DOAC group - direct oral anticoagulants - and their DRP in it's theoretical part. Practical part of thesis is analysis of DRP in GPs office itself. Aim: Theoretical part - describe the process of haemostasis and the possibilities of influencing this process by drugs. Discuss DRP of anticoagulants, especially oral anticoagulants and heparins. Practical part - identify and describe DRP. Sort them by PCNE Classification for DRP V5.01. Analyse and describe the most frequent drug-related problems occurring in general...
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Analysis of spontaneous adverse drug reactions reporting hormonal contraception and hormone replacement therapy
Ryndová, Vendula ; Malá, Kateřina (advisor) ; Horký, Pavel (referee)
Analysis of spontaneous adverse drug reactions reporting hormonal contraception and hormone replacement therapy Author: Vendula Ryndová Supervisor: PharmDr. Kateřina Malá, Ph.D. Consultant: PharmDr. Eva Zimčíková, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Hormonal contraception (HC) is the most widely used method to prevent pregnancy worldwide. In addition to pregnancy planning and other non-contraceptional benefits, it also has certain risks. Hormone replacement therapy (HRT) is used primarily for treatment of estrogen deficiency in postmenopausal women. HRT is associated with a number of risks, in particularly for women 60+ of age. Analysis of spontaneous adverse drug reactions (ADRs) reporting contribute to detection of potential risks associated with pharmacotherapy, thereby increases the safety of the drugs. Aim: The aim of this thesis was to analyse spontaneous ADRs reports of HC and HRT registered in the Czech Central Database of ADRs of the State Institute for Drug Control (SÚKL). Methods: Retrospective analysis of the spontaneous ADRs reports of HC and HRT registered in the database of SÚKL from 10/2004 to 6/2017. Mainly, method of receiving the report, reporting person, patient information, seriousness, and...
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Analysis of drug-related problems in a healthcare facility VI.
Záleská, Kristína ; Doseděl, Martin (advisor) ; Malá, Kateřina (referee)
Title of thesis: Analysis of drug-related problems in a healthcare facility VI. Candidate: Kristína Záleská Supervisor: PharmDr. Martin Doseděl, PhD. Department: Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Background and aim: A drug-related problem (DRP) has been defined as an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes [1]. The theoretical background chapter is aimed to give a detailed description of selected studies dealing with drug-related problems in various settings. The retrospective cross- sectional study, described in the experimental part of the thesis, was carried out in order to identify, classify and assess DRPs in a rehabilitation facility and to discuss the results with a physician and subsequently determine intervention acceptance rate. Methods: The data were collected during a nine-day-long audit in three wards of a rehabilitation facility in the Czech Republic through a review of medical documentation. The detected DRPs were classified using the modified version of PCNE classification v5.01 and their severity was assessed on a scale of 0 to 5. The DRPs were subsequently discussed with physicians and the pharmaceutical intervention acceptance rate was...
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Self-regulation Motives of Czech Journalists along with Routine Professional Decision
Malá, Kateřina ; Trampota, Tomáš (advisor) ; Jirák, Jan (referee)
Diploma thesis "Self-regulation Motives of Czech Journalists along with Routine Professional Decision" deals with regulators which show up in daily pofessional work of journalists at present, i.e. in period when this diploma thesis was written. Motives and influences of each regulator are examined in sample of three nationwide publishers - Mlada fronta Dnes, Pravo and Lidove noviny. Sixteen journalists participated in this survey, which was made in period from March, 16th 2008 to May, 5th 2008. This work is focused on Codes of Conduct (Codes of Ethics) of the surveyed publishers and explores their effects on professional manners of each editor. Furthermore, this diploma thesis is also about journalists personal professional limits which work as personal self-regulators. It investigates what is excusable for editors and what is not, within the survey. This diploma thesis answers on question which regulators influence editors and how editors react. In conclusion this work also deals with self-regulation aspects, if they are considered important by editors or not. This diploma thesis compares results among the above mentioned surveyed publishers as well as within the hierarchy of each publisher.
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Drug Information Centre service analysis IV. - drug interactions
Michálek, Georg ; Malá, Kateřina (advisor) ; Doseděl, Martin (referee)
Drug Information Centre service analysis IV. - drug interactions Author: Georg Michálek Supervisor: PharmDr. Kateřina Malá, Ph.D. Consultant: PharmDr. Petra Rozsívalová Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction: Drug information centre (DIC) of the Faculty of Pharmacy in Hradec Králové, Charles University, and University Hospital Hradec Králové was established in 1994. It provides drug information to healthcare professionals in the form of timely and accurate answers to drug-related enquiries, including drug interactions (DI). Aim: This study aimed to analyse enquiries related to DI processed by DIC from 2015 to 2020 and to solve three drug enquiries related to drug interactions. Methods: Quantitative and qualitative analysis of drug enquiries was carried out. Data was collected from individual enquiries related, but not limited to drug-drug, drug-herbal, and drug-disease interactions. The quantitative analysis based on descriptive statistical methods was performed on two levels: enquiry level and drug interaction level. On the enquiry level, ATC codes found in the enquiries were analysed and on the drug interaction level various parameters assigned to each DI were analysed, such as interacting components,...
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Analysis of spontaneous adverse drug reactions reporting hormonal contraception and hormone replacement therapy
Ryndová, Vendula ; Malá, Kateřina (advisor) ; Horký, Pavel (referee)
Analysis of spontaneous adverse drug reactions reporting hormonal contraception and hormone replacement therapy Author: Vendula Ryndová Supervisor: PharmDr. Kateřina Malá, Ph.D. Consultant: PharmDr. Eva Zimčíková, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Hormonal contraception (HC) is the most widely used method to prevent pregnancy worldwide. In addition to pregnancy planning and other non-contraceptional benefits, it also has certain risks. Hormone replacement therapy (HRT) is used primarily for treatment of estrogen deficiency in postmenopausal women. HRT is associated with a number of risks, in particularly for women 60+ of age. Analysis of spontaneous adverse drug reactions (ADRs) reporting contribute to detection of potential risks associated with pharmacotherapy, thereby increases the safety of the drugs. Aim: The aim of this thesis was to analyse spontaneous ADRs reports of HC and HRT registered in the Czech Central Database of ADRs of the State Institute for Drug Control (SÚKL). Methods: Retrospective analysis of the spontaneous ADRs reports of HC and HRT registered in the database of SÚKL from 10/2004 to 6/2017. Mainly, method of receiving the report, reporting person, patient information, seriousness, and...
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Drug Information Centre service analysis IV. - drug interactions
Michálek, Georg ; Malá, Kateřina (advisor) ; Doseděl, Martin (referee)
Drug Information Centre service analysis IV. - drug interactions Author: Georg Michálek Supervisor: PharmDr. Kateřina Malá, Ph.D. Consultant: PharmDr. Petra Rozsívalová Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction: Drug information centre (DIC) of the Faculty of Pharmacy in Hradec Králové, Charles University, and University Hospital Hradec Králové was established in 1994. It provides drug information to healthcare professionals in the form of timely and accurate answers to drug-related enquiries, including drug interactions (DI). Aim: This study aimed to analyse enquiries related to DI processed by DIC from 2015 to 2020 and to solve three drug enquiries related to drug interactions. Methods: Quantitative and qualitative analysis of drug enquiries was carried out. Data was collected from individual enquiries related, but not limited to drug-drug, drug-herbal, and drug-disease interactions. The quantitative analysis based on descriptive statistical methods was performed on two levels: enquiry level and drug interaction level. On the enquiry level, ATC codes found in the enquiries were analysed and on the drug interaction level various parameters assigned to each DI were analysed, such as interacting components,...
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