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Risk factors of atherosclerosis
 MRAČKOVÁ, Michala
Atherosclerosis and its risk factors are bases of most cardiovascular diseases (CVD), the leading cause of morbidity and mortality in industrial countries worldwide. Recently many new, independent biomarkers have appearred which could in future serve for increasing predictive value of "classical" risk factors of atherosclerosis. That is why in our bachelor thesis we followed the occurrence of classical risk factors which are used for calculation of the risk of fatal cardiovascular event during next ten years along with several new biomarkers in a group of randomly selected clients of a spa resort Savoy in Karlovy Vary without clinical signs of atherosclerosis. The results show that the most frequent risk factor in this population was hypercholesterolemia and a positive family history of a cardiovascular disease. The study group was divided according to the cardiovascular risk. We found that only 57 % of middle-aged persons belong to a group with the minor to medium risk, i.e. while 43 % of the followed parsons had high or very high risk of CVD. According to our expectation, high percentage of persons with a high cardiovascular risk was among men. The population of women suffered from metabolic syndrome in 35 % while the men´s part of the study group had metabolic syndrome even in 52 %. The final part of the thesis studied some "non-traditional" risk factors of atherosclerosis. In the investigated population the highest percentage showed lipoprotein-associated phospholipase (Lp-PLA2), increased concentration of lipoprotein (a) was less frequent and the lowest incidence was found in the case of small dense LDL. Pathological levels of Lp(a) were more frequent in women while increased Lp-PLA2 was found especially in men. Persons with high CVD risk showed higher concentration of Lp-PLA2, the other two factors did not differ between the two groups with different risk score. Nevertheless, the predictive value of Lp-PLA2 with respect to assessment of CVD risk was very low.
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See also: similar author names
6 MRÁČKOVÁ, Marie
6 Mračková, Marie
3 Mračková, Michaela
1 Mračková, Miroslava
6 Mráčková, Marie
2 Mráčková, Martina
3 Mráčková, Michaela
3 Mráčková, Milena
2 Mráčková, Monika
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