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Copper reducing effects of quercetin metabolites
Mísař, Jakub ; Karlíčková, Jana (advisor) ; Říha, Michal (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany and Ecology Candidate: Jakub Mísař Supervisor: PharmDr. Jana Karlíčková, Ph.D. Title of Thesis: Copper reducing effects of quercetin metabolites Copper is an essential trace element in particular due to its ability to easily convert between both redox forms: oxidized (Cu2+ ) and reduced (Cu+ ). Flavonoids are common components of the human diet and they can have positive influence on human health. They are converted into small phenolic acids during digestion by specific bacteria in the colon. Although effects of flavonoids have been extensively studied, the same is not true for their metabolites- phenolic acids. In this in vitro study, eight phenolic acids, which are known metabolites of commonly used flavonoid quercetin, were analyzed for their copper reducing activity at four (patho)physiologically relevant pHs. Simple spectrophotometric method based on an indicator bathocuproinedisulfonic acid disodium salt was used for the assessment reduction of copper ions. The degree of cupric reduction differed among tested compounds. All o- dihydroxycompounds were the most active and achieved 100% of cupric ion reduction in low compound to copper ratio. In conclusion, based on this study, it appears that...
Interaction of phenylpropionic acids with iron
Mísař, Jakub ; Matysová, Ludmila (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany and Ecology Candidate: Mgr. Jakub Mísař Consultant: PharmDr. Jana Karlíčková, Ph.D. Title of thesis: Interaction of phenylpropionic acids with iron Iron belongs to a group of important elements in human body, especially due to ability to accept or donate electrons (conversion between the ferric and the ferrous ions). This element is essential part of human body. Under certain circumstances it may even harm (for example participation in the Fenton reaction). Phenolic acids are structurally very simple molecules, which are part of common diet or they are formed during the digestion. In this in vitro study we tested interaction (chelation and reduction) between the phenylpropionic acids and the iron ions. Seven phenylpropionic acids were evaluated at different pH values. For measurement we used spectrophotometric method, based on the indicator ferrozine. The degree of chelation or reduction of iron ions differed between tested compounds. Higher ability to chelate iron ions achieved all dihydroxycompounds and the 3-(4-hydroxyphenyl)propionic acid. The most active ferric reduction achieved by 3-(3,4-dihydroxyphenyl)propionic acid with catechol group. Iron chelation or reduction by phenylpropionic acids could...

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1 Misař, Jan