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Analysis of intracardiac electrogram of heart arrthytmias in the spectral domain
Karlíková, Adéla ; Králík, Martin (referee) ; Mézl, Martin (advisor)
The most important aspect of successful ablation and destruction of arrhythmia is to find the place where arrhythmia spreads. The site of initial activation can be found by conventional or complex techniques. This thesis describes a new conventional method that can also be applied in practice. It was found that the closer is catheter to the place of the initial activation the more dominant frequency shifts to the higher values. We will use this fact in creating an algorithm which will compare frequency values in the frequency spectrum. This algorithm will also assess how far is the catheter located from the site of the origin of the arrhythmia. In the conclusion of the thesis is an evaluation of the measured clinical data and a comparison of the effectiveness of the method.
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Skin dose mapping for fluoroscopically guided interventions in cardiology
Melichar, Ondřej ; Králík, Martin (referee) ; Mézl, Martin (advisor)
The subject of this work is an issue analysis of possible skin damage inflicted during fluoroscopically guided surgery and design of a radiation dose tracking software for patients undergoing an interventional cardiac surgery. The tool is implemented in Unity 3D engine. Mapping is performed by simulating the X-ray machine movement around an anthropomorphic model in conjunction with simulated irradiation using rays emitted from the X-ray machine. The input data needed for dose tracking compose of radiation dose structured report and patient specific biometrics depending on the anthropomorphic model used. Output data is presented as a heatmap mapped directly onto patient’s 3D. This can be used for early diagnostics of radiation dermatitis.
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Adjustment of diagnostic instrument Array Reader C-series
Čičatka, Michal ; Hesko, Branislav (referee) ; Mézl, Martin (advisor)
Thesis deals with actualization of application for adjustment of the chemical analyser Array Reader C-series developed by company BioVendor. At the beginning it defines and sorts out chemical analysers; then describes their physical principles. Following chapters sum up knowledge about microarray analysis and describes it’s chemical and physical principles. Furthermore, the thesis deals with quality and it’s management and machine adjustment. In the thesis is also mentioned .NET Framework – software platform that will be used in the practical part of the thesis. At the end of the theoretical part is described Array Reader C-series. Practical part documents current application for adjusting the analyser. Based on personal experiences with the adjusting application was created and thoroughly described concept of a new adjusting application. Main task of this new concept should be simplification and automatization of the adjusting process. After that implementation of the new concept is described including automatation processes. In the end of this thesis both original and new versions are compared with regards to time consumption and user experience. Newer version of the application was evaluted as better than it's previous version in light of time consumption and user experience. Application was expanded for fluorescent analyzer and for both types of analyzers were developed derivated applications for service adjustment. Each of these applications was implemented to the software of BioVendor company and is used on daily basis.
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MRI of Rats - Quantification of T1 in Myocardium
Vitouš, Jiří ; Mézl, Martin (referee) ; Jiřík, Radovan (advisor)
This thesis focuses on cardiac imaging and quantification of T1 relaxation time in rat hearts. Its main focus is to investigate available methods for such quantification and their application in the development of quantification tools. The large impact is given to methods of acquisition synchronization, mainly with respect to cardiac motion and breathing using retrospective gating, where the navigator signal is obtained solely from the acquired data, so without any external equipment such as the ECG or respiratory sensors. This paper takes into account situations where steady-state has been reached and also those where it has not, by means of contrast agent injection or by inversion pulses.
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Optimization method based on TRUST for image registration
Pernicová, Lenka ; Mézl, Martin (referee) ; Harabiš, Vratislav (advisor)
The aim of the thesis is optimization for a medical images registration. The basis is to acquaint with the images registration and to peruse component global optimization methods, especially an optimization method TRUST. After theoretic knowledge it is possible to proceed to a suggestion of an optimization method based on the TRUST method and to realize in the program setting MATLAB. Created algorithms has been tested on test data and compared with other optimization methods as Simulated annealing.
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Eye movement tracking using the Raspberry Pi platform
Hunkařová, Nikol ; Mézl, Martin (referee) ; Hesko, Branislav (advisor)
This master's thesis deals with eye movement tracking using the Raspberry Pi platform. The theoretical part describes eye anatomy, eye detection and eyetracking. A system in Python programming language was designed in the practical part. This algorithm is able to perform the eye tracking function using the Raspberry Pi platform and the RPi Camera module. The OpenCV library is used for loading and preprocessing images from the camera. A method that detects and evaluates the direction of view after a calibration is available. The accuracy of the program is tested on three vector methods and two target methods for four screen resolutions.
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Detection of pathologies in ECG signals
Němec, Radek ; Mézl, Martin (referee) ; Kašpar, Jakub (advisor)
This thesis attempts with methods for detection of pathologies in ECG signals. The first part is focused on the basic theory of heart anatomy, electrocardiography and individual heart pathologies. The second part describes the preprocessing of ECG signals, detection of QRS complexes and detection of individual pathologies. In the third part the detector is being tested on CSE database and my own measured data.
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Ultrasound Image Sequences Segmentation
Kořínek, Peter ; Jiřík, Radovan (referee) ; Mézl, Martin (advisor)
When we scan image data by ultrasound, we have a little information of displayed scene. For understanding content of the image we try to separate the observed objects of interest from the background. Obtaining information of these objects is called a process called segmentation. This work is focused on the segmentation of ultrasound image sequences using geometric active contours solved by the method of level sets. For better representation is also dealing with image preprocessing. The result is an implementation of segmentation methods on simulated and real data.
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Registration of MR Images and Histological Sections
Martinásková, Klára ; Mézl, Martin (referee) ; Jiřík, Radovan (advisor)
This bachelor’s thesis deals with methods of multimodal image registration. The work is focused specifically on the registration of histological sections and MR images, which various studies examine because of improving oncological diagnostics. A substantial part of the work is devoted to theories of registration - types of registration, geometric transformations, criterial functions, interpolation and methods of optimization. There is also an overview of tools, which can be used for multimodal image registration. MR images and histological sections were provided from three different sources. The program for image registration was created in software MATLAB 2020a with a graphical user interface and it includes a converter for editing images before the registration began. In conclusion, the results of registration were analyzed.
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Reduction of metal artifacts in CT data with submicron resolution
Víteček, Jiří ; Mézl, Martin (referee) ; Jakubíček, Roman (advisor)
This diploma thesis deals with reduction of metal artifacts in CT data with submicron resolution. The first part of this thesis briefly describes x-ray computed tomography followed by the description of artifacts of tomographic images and existing approaches of the reduction of metal artifacts. In the second part proposed methods of reduction of metal artifacts and their implementation in Matlab programming environment are described. Finally functionality of algorithms is tested on a newly created database and the results are compared, evaluated and discussed.
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