National Repository of Grey Literature 5 records found  Search took 0.00 seconds. 
Use of NIC, NOC classification of patients after spinal surgery
MACHOVÁ, Karolina
Generally, the main topic of the thesis is the use of NIC and NOC classification of patients after a spinal surgery. The theoretical part of the thesis deals with a trauma of the spine as well as a non-traumatic affection of the spine and its symptoms, diagnostics, and treatment. Further, it focuses on nursing care of patients before and after a spine surgery. Firstly, general terms of the nursing care, such as control of vital functions, are analysed. The next part is devoted to the specifics of nursing care with respect to every segment of the spine after surgery. The next chapter of the theoretical part of the thesis describes the nursing process with emphasis on every phase thereof, and related medical documentation with its use and rules. Moreover, the respective chapter deals with the nursing diagnoses NANDA, NIC and NOC classifications and Alliance 3N. The first goal of the thesis was to find out what knowledge nurses have regarding nursing care for patients after spinal surgery. My research has revealed that the majority of nurses are well-oriented in nursing care for patient after spinal surgery, despite some of nurses' lack of knowledge. The second goal set for this thesis was to determine what are the benefits of NIC, NOC classifications for providing nursing care for patients after spinal surgery. According to the results of my research, we can conclude that most nurses consider the classification of NIC and NOC in practice rather unhelpful. This piece of information also answers the established research question: Is NIC and NOC classification according to nurses beneficial in practice? Furthermore, the following two goals: to find out what NIC interventions nurses use by patients after spinal surgery. To find out what goals of NOC classification are typically used by nurses, are contained in Tables 3-10. The result of the research question, what do nurses think about the NIC and NOC classification, showed mostly negative opinions. For another research question: How satisfied are nurses with the created nursing documentation with respect to nursing care for patients after spinal surgery, we found out that most nurses are rather dissatisfied with the submitted nursing documentation. Furthermore, two hypotheses were established: H1: Knowledge of the principles of nursing care for patients after spinal surgery are affected by the experience, was rejected. H2: Knowledge of the principles of nursing care for patients after spinal surgery are affected by education, was also rejected. Despite the fact, that NIC and NOC classifications are not used in health care services in the Czech Republic, many nurses knew them. Because of the fact that many nurses have rather negative attitude with respect to the classifications, we can assume that if the classifications were adapted to the conditions of the Czech healthcare system and there would be certain changes such as simplification or shortening of content, nurses might have a more positive approach to the classifications. Therefore, NIC and NOC classification could be part of the nursing standards of practice, as they are verified tools for providing nursing care.
Metabolomic analysis of plasma samples using ultra performance liquid chromatography and high resolution mass spectrometry
Machová, Karolína ; Solich, Petr (advisor) ; Kujovská Krčmová, Lenka (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Karolína Machová Consultant: Prof. RNDr. Petr Solich, CSc. Diploma Thesis Title: Metabolomic analysis of plasma samples using ultra performance liquid chromatography and high resolution mass spectrometry Metabolomics is a novel type of science which represents a complex methods of metabolite determination in biofluid e.g. plasma, urine, saliva, cerebrospinal fluid and sperm. The method describes cell mechanisms and finds wide assertion in disease diagnostics, biomarkers description, disease, pathophysiology and in clinical practice. It is vital to have a sensitive method because levels of metabolites are quite low. Metabolomic analysis uses mainly high-performance liquid chromatography combined with mass spectrometry for detection. However, other methods such as nuclear magnetic resonance spectroscopy and gas chromatography can also be used. Presented work is mainly focused on method standardization for identifying metabolites in clinical practice with the use of ultra-performance liquid chromatography and mass spectrometry. The primary outcome was to establish searching parameters for the operating software to automatically identify xenobiotics in provided sample and compare them with...
Issues relating to caring for patients with leukaemia.
MACHOVÁ, Karolina
The theoretical part of my bachelor thesis is primarily focused on nursing care of the patient diagnosed with leukemia and related issues. Purpose of the thesis is to describe this serious disease with an unfavourable prognosis. The theoretical part is built on the basis of analysis of available sources of information concerning the given topic. Two major goals were set for this bachelor thesis. The first objective is to determine the specifics of the nursing care of the patients with leukemia. The second goal was to establish the main issues connected with the nursing care of patients with leukemia. Two research questions were created on grounds of the objectives defined. Those research questions were: What are the specifics of the nursing care of the patients with leukemia? What are the most common issues that nurses have to cope with when treating patients with leukemia? For processing of results acquired in the empirical part of the thesis the form of qualitative research was chosen using the method of semi-structured interviews. The choice of the nurses was intentional, therefore only nurses providing care to the patients with leukemia were addressed. Both research questions were answered and both goals were met. Results from answers received from the nurses were divided into categories and consequently processed. It is necessary for the nurses to comply with the standards in order to avoid complications regarding the patient with leukemia whose immunity is well weakened. Therefore, I would suggest lectures and seminars extension in the hospitals in order to ensure the best quality care for patients with leukemia. This bachelor thesis can be helpful to the students who wish to acquire new information about given disease and provide better understanding of the described issue.
Synthetic studies on vasicinone leading to bronchodilatory active compounds
Machová, Karolína ; Špulák, Marcel (advisor) ; Kuneš, Jiří (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Inorganic and Organic Chemistry Candidate: Mgr. Karolína Machová Consultant: PharmDr. Marcel Špulák, PhD. Title of Thesis: Synthetic studies on vasicinone leading to bronchodilatory active compounds The aim of this thesis was synthesis of quinazolines with potential bronchodilatory activity having attached in position 4 of the heterocycle alkoxy- or alkylamino- side-chain possessing basic centre. This work is a continuation of previous syntheses of quinazoline derivatives structurally derived from alkaloids vasicine and vasicinone, where so far the most active compound was 4-[3-(piperidin-1-yl)propylsulfanyl]quinazoline, with the side-chain possessing sulfur atom. Originally, attempts to synthesize the target structures employing the cyclisation of N-(2-cyanophenyl)formamide were carried out, however, after overcoming the problems within the preparation of this intermediate, the cyclisation was unsuccessful, therefore starting quinazolin-4-ol was converted into its 4-chloro derivative and subsequent nucleophilic attack of alcoholate or amine allowed us to prepare five target compounds. All synthesized quinazolines were submitted for an evaluation of their bronchodilatory activity. Unfortunately, none of the tested...
Metabolomic analysis of plasma samples using ultra performance liquid chromatography and high resolution mass spectrometry
Machová, Karolína ; Solich, Petr (advisor) ; Kujovská Krčmová, Lenka (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Karolína Machová Consultant: Prof. RNDr. Petr Solich, CSc. Diploma Thesis Title: Metabolomic analysis of plasma samples using ultra performance liquid chromatography and high resolution mass spectrometry Metabolomics is a novel type of science which represents a complex methods of metabolite determination in biofluid e.g. plasma, urine, saliva, cerebrospinal fluid and sperm. The method describes cell mechanisms and finds wide assertion in disease diagnostics, biomarkers description, disease, pathophysiology and in clinical practice. It is vital to have a sensitive method because levels of metabolites are quite low. Metabolomic analysis uses mainly high-performance liquid chromatography combined with mass spectrometry for detection. However, other methods such as nuclear magnetic resonance spectroscopy and gas chromatography can also be used. Presented work is mainly focused on method standardization for identifying metabolites in clinical practice with the use of ultra-performance liquid chromatography and mass spectrometry. The primary outcome was to establish searching parameters for the operating software to automatically identify xenobiotics in provided sample and compare them with...

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