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Venticular activation patterns in conduction abnormalities and during different pacing modes (aktivační sekvence při poruchách komorového vedení a různých typech komorové stimulace)
Peichl, Petr ; Kautzner, Josef (advisor) ; Lukl, Jan (referee) ; Kittnar, Otomar (referee)
Academic dissertation: Ventricular activation patterns in conduction abnormalities and during different pacing modes Petr Peichl, MD, Department of Cardiology, IKEM, Vídeňská 1958/9, Prague, Czech Republic 5 Congestive heart failure (CHF) is a progressive disease caused by left ventricular dysfunction with high morbidity and mortality rates. Ventricular dysfunction is often linked to ventricular dilatation, which in turn may cause ventricular conduction delays and further worsening of the cardiac function. Recent decade gave rise to cardiac resynchronization therapy (CRT), a therapeutic modality based on premise that preexcitation of late activating10 regions by cardiac pacing may restore the left ventricular synchronous contraction. The goals of the publications included in the dissertation were: (1) to analyze the ventricular activation patterns in patients eligible for CRT with respect to the underlying heart disease and/or QRS morphology on the surface electrocardiogram(ECG), (2) to quantify changes in ventricular activation patterns during different pacing modes and (3) to compare15 the hemodynamic performance of different pacing modes during exercise. 1. Patients with CHF and wide QRS complex represent a broad spectrum of underlying conduction disturbances with variable inter- and intraventricular...
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