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Differences in growth parameters in SGA / IUGR children and patiens with growth hormone deficiency treated with recombinant growth hormone
Kročilová, Kateřina ; Sedlak, Petr (advisor) ; Lisá, Lidka (referee)
In the Czech Republic is born to 5 % of SGA / IUGR children, about 5, 000 children a year, and their incidence is increasing. In 10 - 15 % does not occur postnatal compensation growth acceleration and growth retardation is then further deepens. Since 2003, these children can be treated by recombinant growth hormone in supraphysiological doses. Master thesis brings informations about SGA / IUGR children and their growth parameters during the first 2 years from the beginning of treatment when the monitoring was carried out at three - month intervals. The results are compared with the group of patients treated with growth hormone for growth hormone deficiency. Growth data was processed by a group of 57 SGA / IUGR children, which was compared with data of 34 children with growth hormone deficiency treated between 2003-2015 with growth hormone. Treatment of both groups of patients was carried out by a suitable therapeutic protocol, with the dose of GH by the respective diagnosis. These parameters were monitored: body height and weight, growth rate, BMI and weight - height ratio of patients. SGA / IUGR and GHD patients showed different growth profile in the initial phase of treatment when GHD patients had higher acceleration peak after 3 months of starting treatment and steeper increase in growth rate....
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Differences in growth parameters in SGA / IUGR children and patiens with growth hormone deficiency treated with recombinant growth hormone
Kročilová, Kateřina ; Sedlak, Petr (advisor) ; Lisá, Lidka (referee)
In the Czech Republic is born to 5 % of SGA / IUGR children, about 5, 000 children a year, and their incidence is increasing. In 10 - 15 % does not occur postnatal compensation growth acceleration and growth retardation is then further deepens. Since 2003, these children can be treated by recombinant growth hormone in supraphysiological doses. Master thesis brings informations about SGA / IUGR children and their growth parameters during the first 2 years from the beginning of treatment when the monitoring was carried out at three - month intervals. The results are compared with the group of patients treated with growth hormone for growth hormone deficiency. Growth data was processed by a group of 57 SGA / IUGR children, which was compared with data of 34 children with growth hormone deficiency treated between 2003-2015 with growth hormone. Treatment of both groups of patients was carried out by a suitable therapeutic protocol, with the dose of GH by the respective diagnosis. These parameters were monitored: body height and weight, growth rate, BMI and weight - height ratio of patients. SGA / IUGR and GHD patients showed different growth profile in the initial phase of treatment when GHD patients had higher acceleration peak after 3 months of starting treatment and steeper increase in growth rate....
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Pathogenesis of germ cell tumor development: Application of current knowledge in early diagnostics in patient with disorders of sex development
Kaprová, Jana ; Lebl, Jan (advisor) ; Lisá, Lidka (referee) ; Zapletalová, Jiřina (referee)
Patients with disorders of sex development with an increased risk for development of gonadal germ cell tumors mostly undergo prophylactic gonadectomy, that always leads to a need for hormonal substitution, and moreover, in some cases prevents fertility. The aim of the thesis was to better determine the risk for tumor development in relation to the functional and phenotypical characteristics in patients with complete form of androgen insensitivity syndrome (CAIS) and patients with 45,X/46,XY gonadal dysgenesis (GD). Hematoxiline and eosine staining and immunohistochemical detection of OCT3/4, TSPY and KITLG were used to assess 37 and 36 gonadal tissue samples of 19 CAIS patients, respectively, and 84 samples from 47 patients with 45,X/46,XY GD. The results were correlated with gonadal position and expected level of androgen receptor activity in the first group. The gained data were compared with level of virilization of external gentalia in the second group. Due to an unequal distribution in relation to the age in patients with CAIS, it was not possible to independently assess the influence of gonadal position (inguinal versus abdominal) on the histological gonadal changes. Expected residual androgen receptor activity has a positive effect on survival of general germ cell population but not on the...
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