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NK cells and KIR receptors: their importance in haematopoietic stem cell transplantations in leukemia
Ledvinková, Anna ; Vraná, Milena (advisor) ; Pačes, Jan (referee)
NK cells and KIR receptors: their importance in haematopoietic stem cell transplantations in leukemia Abstract This bachelor thesis discusses the importance of NK (natural-killer) cells in leukemias. It focuses on the structure and reactivity of NK cells, and especially on transmembrane KIR receptors (killer cell immunoglobulin-like receptors) of NK cells, that play an important role in the elimination of leukemic cells (graft-versus leukemia reaction, GvL) and thus in the overall prognosis of the disease. Activation and inhibitory receptors of KIR, by their cooperation, control the cytotoxic activity of NK cells. Thus, the typing of KIR receptor genes in hematopoietic stem cell donors can predict treatment success. KIR genes examination is mainly used in patients diagnosed with acute myeloid leukemia. Keywords: KIR receptor, NK cells, haematopoietic stem cell transplantation, HSCT, leukemia, donor, recipient
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