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National Repository of Grey Literature 3 records found  Search took 0.00 seconds. 
Benigní helmint Hymenolepis diminuta pozitivně ovlivňuje chemicky vyvolanou kolitidu u potkaního modelu
 LEVÁ, Jana
In this study is examined the protective effect of different life cycles stages of rat tapeworm Hymenolepis diminuta against dinitrobenzene sulphonic acid (DNBS) induced colitis in rat model. The clinical health of rats, gut microbiota and systemic inflammation was analysed. For determination of the level of inflammation and type 2 immune response of rat model was used relative gene expression of TNF, IL-1, IL-4, IL-13 and IL-10 using real-time PCR. Our results showed that colonization by immature life stages of H. diminuta before the induction of DNBS colitis reduced clinical symptoms and inflammation in rat model but did not protect rats against colitis. Type 2 immune response was detected by an increase in gene expression of IL-4, IL-10 and IL-13. The gut microbiota does not substantial role in H. diminuta-mediated protection.
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Imunomodulační účinky extraktů z helminta na střevní buněčnou linii potkaního modelu
 LEVÁ, Jana
In this study, we examined the immunomodulatory effect of excretory/secretory products, crude adult extracts and crude larvae extracts from Hymenolepis diminuta on the intestinal epithelilal cell line from a rat. For determination of the immunomodulation effect of all H. diminuta extracts was used relative gene expression of TNFa, IL-17re and IL-33 from epithelial cells and it was tested using real-time PCR. Our result showed that excretory/secretory products had the strongest antiinflammatory effect on the epithelial cells. We assume that crude adult extracts play an important role in increase of gene expression of IL-33 and also in the immunomodulatory ability of H. diminuta in the host organism.
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Sledování změn genové exprese interleukinu 10 u potkana jako modelového organizmu v průběhu infekce tasemnicí \kur{Hymenolepis diminuta}
 LEVÁ, Jana
In this study, we examined the gene expression of interleukin 10 (IL-10) mobilized by rats during prepatent and patent period of Hymenolepis diminuta infection. Relative IL-10 gene expression was determined from blood samples using real-time PCR. Our results showed that IL-10 gene expression is significantly increased in the begining of the prepatent period of H. diminuta infection in the rat model system.
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