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The Students themselves - Student Center Poříčí
Kubínová, Šárka ; Sirotek, Adam (referee) ; Makovský, Zdeněk (advisor)
The topic of my thesis is the student center at Poříčí - on the corner Táborského nábřeží and street Vídeňská. It proposes seven-storey building containing student housing, student`s canteen, sports facilities and a calm inner courtyard. The building is addressed clearly and simply. It closes to the busy Street Vídeňská and it opens towards the River.
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Completion of the area Údolní 53 for the Faculty of Architecture and Faculty of Fine Arts
Stejskal, Ivo ; Kubínová, Šárka (referee) ; Makovský, Zdeněk (advisor)
It is necessary to ask the question of the relationship and the corresponding forms of buildings of the faculty of architecture and faculty of fine arts with the public. Due to the efforts of the faculties to open up to the public, I find it undesirable to place new objects in the courtyard and hide behind the walls of historic buildings. Much more meaningful is the use of existing buildings at the boundary of the plot. It is important to protect our history, but the protection of existing buildings should not get to the point where it will defend the presence, be on the same level, and thus ensure its quality and together to shape the future. The newly allocated creative use of the original barracks has greater demands on space, whether capacity or its generosity. Therefore, it is necessary to customize the objects for the current function. The superstructure will help keep faculties in one building. An advantage is also the connection to existing networks or vertical communications. The proposed minimalist intervention is in contrast to the historic building, making it stand out, while the verticalism of the superstructure raises the object of the original barracks to the desired institution of the Faculty of Architecture and the Faculty of Fine Arts.
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Socio-cultural centre Dolní Kounice
Vašut, Štěpán ; Kubínová, Šárka (referee) ; Mikulášek, David (advisor)
My diploma thesis is based on the module Res Publica - Public works focusing on community buildings. Dozens of towns were surveyed, whether they are interested in reconstruction of their community or sociocultural centre, and eventually a small town Dolní Kounice was chosen especially because of the beauty of the surrounding countryside as well as the exciting native urbanism and architecture. This thesis deals with transformation of the cultural house from the 50s of the 20th century to a new cultural centre. The extension and inconvenient terrace were removed and the hall is supported by a new mass of the vestibule at the interface between interior and exterior, on the site of the former patio. Next, a new front of the building was introduced which increased the entrance of the house and created a space for a study room, small gym, meeting room and common rooms. The part of the house used for housing units is designed only with aesthetic details on the facade. The Culture Centre is divided into a set of materials in order to reduce the scale of the whole building. The entrance part mass, in contrast, is enhanced by its division and the chosen materials. In this way the originally embarrassing object of the Cultural Centre has been changed into a new centre with a clear architectural expression and the interior of the house is enriched by view of the beauty of the city.
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Residential Complex in Brno - Komín
Pospíšilová, Zuzana ; Kubínová, Šárka (referee) ; Makovský, Zdeněk (advisor)
This design is based on the site's strong potential in regards to its attractive location near Brno city centre and at the same time its proximity to nature. The solution of volumes results from an effort to create a system of public through private spaces while maintaining the continuity of the whole. This residential complex can offer apartments of all sizes, from flatlets to five bedroom flats and even houses. It also provides its neighborhood with new possibilities to shop and to spend time outdoors.
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Living by the river
Malahefji, Tarek ; Kubínová, Šárka (referee) ; Wittmann, Maxmilian (advisor)
The city of Brno is the capital of Moravia in the Czech Republic which was shaped by many historical events, its predominant textile industry was amongst the most important aspects of these criteria, since its main rivers cut through the city (Svratka, Svitava), this industry and its trade, was a main factor in shaping the city as a whole, alongside political conflicts, change of regimes. During the 1960s, after the planned style economy was settled completely, it resulted in big setbacks for the Czechoslovak economy, as the textile industry started to crumble. The final blow to this industry happened after the velvet revolution as privatization took place and most remaining factories were dismantled. This narrative had a big role in shaping how Brno looks today as the northern part of the city is more urbanized than the southern part which is more industrialized by nature, and unlike Prague, these two main rivers are not widely crucial to the public life. This also developed along with other factors a major problem with accommodation quality, price as official data reports increasing dissatisfaction from inhabitants with housing.
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Mesenchymal stem cells for treatment of spinal cord injury
Dubišová, Jana ; Kubinová, Šárka (advisor) ; Hock, Miroslav (referee)
Poranenie miechy a jeho terapia pomocou mezenchymálnych kmeňových buniek Abstract Patients with serious spinal cord injury (SCI) have a little chance of a full return to their original life. This kind of injuries leaves lifelong consequences as on the patients themselves, as well as their surroundings and family. Considerable financial resources are, worldwide, granted for reintegratation of these patients into society. This work focuses on the description of spinal cord injury, its complexity and the possibility of treatment by new therapeutic methods of mesenchymal cells. The first section discusses the severity of spinal cord injury and its pathophysiology with the performance of subsequent clinical phases. The second part is dedicated to new treatment methods and approaches, with an emphasis on cell therapy. The third part presents treatment method using mesenchymal stem cells (MSCs), which immunomodulatory and anti-inflammatory properties, such as their ability to migration to the injured area and the possibility of genetic modification, made them a great candidates for the treatment of serious injuries. Keywords Spinal cord injury, stem cells, mesenchymal stem cells, cell therapy, regenerative medicine
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Mesenchymal stromal cells and biological scaffolds for neural tissue regeneration
Kočí, Zuzana ; Kubinová, Šárka (advisor) ; Filová, Eva (referee) ; Zach, Petr (referee)
Despite tremendous progress in medicine, injuries of the adult central neural system remain without satisfactory solution. Regenerative medicine employs tissue engineering, cellular therapies, medical devices, gene therapy, or growth factors with the aim to bridge the lesion, re-establish lost connections and enhance endogenous repair in order to restore neural function. The aim of my thesis was to evaluate therapeutic potential of two approaches, transplantation of human mesenchymal stromal cells (hMSCs) and biological scaffolds derived from extracellular matrix (ECM) for neural regeneration, particularly in models of spinal cord injury (SCI). First, hMSCs from various sources - bone marrow (BM), adipose tissue (AT) and Wharton's jelly (WJ) - were isolated and characterized in vitro. All cell types met the minimal criteria for MSC phenotype and displayed similar properties in terms of their surface marker expression, differentiation potential, migratory capacity, and secretion of cytokines and growth factors. On the other hand, the cell yield from WJ and AT was significantly higher, and MSCs isolated from these tissues proliferated better than from BM. Therapeutic effect of intrathecal application of hWJ-MSCs was then evaluated in SCI compression model in rats. The effect of low (0.5 million) and...
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