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New diagnostic and therapeutic aspects of inflammatiory cardiomyopathy
Kuchynka, Petr ; Šimek, Stanislav (advisor) ; Krejčí, Jan (referee) ; Gregor, Pavel (referee)
Introduction: Inflammatory cardiomyopathy (DCMi) represents a non-familial form of dilated cardiomyopathy (DCM) and endomyocardial biopsy (EMB) is crucial for its diagnosis. Aims: To assess the prevalence of DCMi in patients with DCM of unclear origin, to evaluate the significance of serological tests for antibodies against infectious cardiotrophic agents and to analyze the effect of specific therapy guided by EMB results. Methods: EMB was performed in 56 subjects (mean age 52 ± 10 years) with DCM of unclear etiology and left ventricular (LV) ejection fraction (EF) < 40% with a history of heart failure less than 1 year. EMB samples were analyzed by immunohistochemistry, polymerase chain reaction (PCR) and electron microscopy. Results: Immunohistochemical examination revealed myocardial inflammation in 26 patients (46%), the PCR method detected genome of microbial agents in 32 patients (57%). Electron microscopy showed the presence of particles of microbial agents in 41 patients (73%). Serological blood tests found no IgM antibody positivity against any of the investigated microbial agents. Targeted antibiotic therapy in patients with evidence of Borrelia burgdorferi (Bb) genome in the EMB led to a reduction in LV size, improvement of LV EF and alleviate symptoms of heart failure. Conclusion: DCMi...
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Genetic and clinical correlates in hypertrophic cardiomyopathy
Čurila, Karol ; Gregor, Pavel (advisor) ; Málek, Ivan (referee) ; Krejčí, Jan (referee)
Hypertrophic cardiomyopathy (HCM) is a hereditary disease, which is caused by mutations in genech coding for proteins of carcomere of heart muscle. Disease is characterised by wide genotypic and fenotypic heterogeneity. Since the 90-th of 20-th century, when the first mutation responsible for HCM was identified, many research was done in detecting the correlation between mutant gene and clinical picture of the affected patient. As the first in Czech republic, we determined the frequencies of 4 most common genes in HCM in czech patients. We figured out, that spectrum of mutations is somehow different from another populations. We didn't find any correlation between specific gene mutation and morfologic and clinical characteristics of affected subjects. In our study with AT-1 receptor blocker - candesartan, we demostrated positive effect of candesartan on level of hypertrophy and function of the left heart ventricle and clinical symptoms of the patients with HCM.
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Phenomenon Cimrman
Krejčí, Jan ; Mocná, Dagmar (advisor) ; Peterka, Josef (referee)
The introduction of this diploma thesis summarizes the production of , and it identifies the two following layers of authorship. The first layer is the fictional authorship of Jara Cimrman; the second layer is the authorship of the Cimrmanologists and their so-called (or fictional) reconstructions of Cimrman's work. The introduction further discusses the importance of the radio show , which gave birth to the character of Jara Cimrman. Finally, the introduction analyses various aspects of Cimrman and his mystifying character. The core of this thesis consists of an analysis of Cimrman and his relation to Czech Dream. It also studies the Czech dream and its development. The second chapter provides a study based on the play , which is looking at the relation between Cimrman and Czech history and the national myth. The beginning of this chapter offers an overview of the history of the . The chapter then continues with an analysis of Cimrman's play with a special attention to its unusual political dimension. The third chapter studies the connections between Cimrman, or his creators, and Czech national consciousness and Czech culture as they are reflected in Cimrman's play . The play is set in the context of Kainar's poem , Klusak and Remunda's film , Macura's essay , and Kaspar's book .
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Economic Aspects of Ensuring Safety and Fire Protection
Krejčí, Jan ; Pánková, Ludmila (advisor) ; Aulová, Renata (referee)
This bachelor thesis discusses and deals with economic aspects of work´s safety and fire protection in workspaces and common areas. The thesis itself contains a literary review summary of all obligations of legal entities and individuals doing business in the field of occupational safety and health and fire protection based on the statute book. As part of this own work there are analysis of costs for ensuring all obligations to provide safety and fire prevention at the ice rink stadium, the Kindergarten and Elementary school buildings in Roudnice nad Labem. The results were compared and according to them was created a costing draft structure.
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Optimization of the ground network infrastructure of radio navigation aids for RNAV in FIR Praha
Krejčí, Jan ; Vosecký, Slavomír (referee) ; Ptáček, Pavel (advisor)
This diploma thesis concerns with creating of study which deals with the optimization of the ground network infrastructure of radio navigation aids for RNAV in FIR Praha. The thesis contains an analysis of concept of development of Czech navigation environment and introduces DEMETER software, in which the optimization analyses are realized. The thesis describes DME/DME navigation system from the perspective of individual components and parameters. The actual study deals with an optimization of the ground network infrastructure of the radio navigation aids and includes the definition of network performance requirements, creation of general methodology of optimization of navigation performance analysis and a procedure of choosing a suitable placement of radio navigation aid. The integral parts of the study are analyses of current state of navigation performance and analyses of possible improvement of radio navigation infrastructure.
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Design systems used in the field of electrical apparatuses
Stejskal, Jiří ; Krejčí, Jan (referee) ; Valenta, Jiří (advisor)
Bachelor´s thesis is engaged on the base of submitter´s requests company OEZ, s.r.o. and is divided into two parts. The first part of work deals with the most often used 2D CAD systems that are used by designers according to their answers in the area of suggestion of electric switchboards low voltage. In the work are described main possibilities of these systems, then what kinds of data format are supported by them. In the second part of the work are described programs established on calculation of warming switchboards. It goes about programs, which supply concrete producer of switchboard case, and further programs based on method of final elements and method of final volume, which enable graphic representation of results.
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3D CAD systems used in the field of electrical apparatuses
Makki, Zbyněk ; Krejčí, Jan (referee) ; Valenta, Jiří (advisor)
The aim of this project is to describe and compare individual 3D CAD systems and data format used in the area of construction and technical support in agreement with factual needs of project submitter company OEZ, Ltd. Fulfilment of 3D CAD systems background research which are used in the area of design of the electrical switchboards LV. Description of the main possibilities, that the particular system offers. Supported data format for export and import are mentioned too.
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